72‐h Infusion of Prostacyclin in Mechanically Ventilated Patients with Pulmonary Infection and Endotheliopathy

Acute respiratory failure (ARF) is common in critically ill patients, and 50% of patients in intensive care units require mechanical ventilation. The COVID‐19 pandemic revealed that COVID‐19 infection induced ARF... read more

Multidisciplinary Collaborative Bundled Care Improves Outcomes in ICU Patients with Endotracheal Intubation

Multidisciplinary analgesic and sedative bundled care has demonstrated the potential to decrease restraint use in patients undergoing endotracheal intubation and mechanical ventilation, reduce the need for analgesic and sedative... read more

Misunderstanding Buffering in Critical Illness

It is was disappointing to read the recent review in Intensive Care Medicine on buffering in metabolic acidosis. I consider this a "pre-Copernican" approach to acid–base that does not respect basic physical–chemical principles. The... read more

Prediction of Prolonged Mechanical Ventilation in the ICU via Machine Learning

Early recognition of risk factors for prolonged mechanical ventilation (PMV) could allow for early clinical interventions, prevention of secondary complications such as nosocomial infections, and effective triage of hospital... read more

Mechanical Ventilation Timing in Sepsis

A recent study by Dr. Kim and colleagues examined the association between the timing of mechanical ventilation (MV) and clinical outcomes in ICU patients with sepsis. The study included 2440 adult sepsis patients from... read more

Early Tracheostomy in Ventilated COVID-19 Patients Reduces VAP Incidence

Tracheostomy can reduce mechanical ventilation (MV) duration, ICU and hospital length of stay (LOS), and ventilator-associated pneumonia (VAP) risk in critically ill patients. The timing of tracheostomy in COVID-19 patients... read more

Pitfalls in the Management of Mechanical Ventilation: ARDS and Hypermetabolic States

Mechanical ventilation (MV) is a lifesaving intervention for patients with respiratory failure due to acute respiratory distress syndrome (ARDS) and septic shock. ARDS was first recognized in the late 1960s, approximately... read more

Respiratory Monitoring in Mechanical Ventilation: Techniques and Applications

Respiratory Monitoring in Mechanical Ventilation: Techniques and Applications

This book covers the up-to-date advancement of respiratory monitoring in ventilation support as well as detecting the physiological responses to therapeutic interventions to avoid complications. Mechanical ventilation nowadays... read more

Impacts of Initial ICU Driving Pressure on Outcomes in Acute Hypoxemic Respiratory Failure

Driving pressure (DP) is a marker of severity of lung injury in patients with acute respiratory distress syndrome (ARDS) and has a strong association with outcome. However, it is uncertain whether limiting DP can reduce... read more

Teaching Pearls in Noninvasive Mechanical Ventilation

Teaching Pearls in Noninvasive Mechanical Ventilation

This book uses real-world clinical case analyses of hot topics to provide insights into noninvasive mechanical ventilation (NIV). Written by leading international teachers and experts, it features a selection of "major... read more

Preventing VAP Non-Pharmacologically

In critically ill, intubated patients on intensive care unit (ICU), ventilator-associated pneumonia (VAP) is a significant complication contributing to substantial mortality, morbidity, and prolonged stays, which in turn... read more

Ventilator Management: A Pre-Hospital Perspective

Ventilator Management: A Pre-Hospital Perspective

The goal of this book is to provide the most up to date information on mechanical ventilation based on current research, evidence based practice and my experiences as a flight paramedic and educator. A comprehensive look... read more

How I Perform Diaphragmatic Ultrasound in the ICU

The diaphragm is a thin, dome-shaped muscle, comprising a costal and crural part, and a non-contracting central tendon. Muscle fiber activation shortens and thickens the diaphragm in the zone of apposition, moving the dome... read more

Spontaneous Breathing Trials Should Be Adapted for Each Patient According To The Critical Illness

Unassisted SBTs, namely PSV0PEEP0 and T-piece trial, are the most appropriate to replicate the postextubation effort to breathe. In this multicentre randomized cross-over study, adult intensive care unit patients under... read more

Outcomes and inflammation changes in different types of immunocompromised patients with critically ill COVID-19 admitted to ICU

Critically ill COVID-19 patients admitted to the ICU exhibit distinct clinical outcomes based on their immunosuppression status, with cancer patients facing the highest mortality rate due to variations in inflammatory responses... read more

A Retrospective Closed Cohort Study on Distribution of Multidrug-Resistant Bacteria in VAP and its Impact on Patient Outcome

Gram-negative organisms, particularly Klebsiella and Acinetobacter, were the main multidrug-resistant (MDR) ventilator-associated pneumonia (VAP) culprits. MDR-VAP exhibited higher morbidity and mortality. A study... read more

Reducing Deep Sedation and Benzodiazepine Use in Mechanically Ventilated Patients During Critical Care Transport

The rate of deep sedation in this cohort was consistent with previously published data; however, it remains higher than clinically indicated. Over the course of the QI project, the proportion of deeply sedated patients... read more