Noninvasive Ventilation in Hypercapnic COPD

Recently, Murphy and colleagues reported findings from a clinical trial designed to evaluate the effect of home noninvasive ventilation (NIV) with oxygen on time to readmission or death in patients with persistent hypercapnia... read more

Noninvasive Ventilation in Hypercapnic COPD

Variation of Poorly Ventilated Lung Units Measured by EIT to Dynamically Assess Recruitment

Assessing alveolar recruitment at different positive end-expiratory pressure (PEEP) levels is a major clinical and research interest because protective ventilation implies opening the lung without inducing overdistention.... read more

Variation of Poorly Ventilated Lung Units Measured by EIT to Dynamically Assess Recruitment

Early Application of APRV May Reduce the Duration of Mechanical Ventilation in ARDS

Compared with LTV, early application of airway pressure release ventilation (APRV) in patients with ARDS improved oxygenation and respiratory system compliance, decreased Pplat and reduced the duration of both mechanical... read more

Early Application of APRV May Reduce the Duration of Mechanical Ventilation in ARDS

Principles And Practice of Mechanical Ventilation

A comprehensive, authoritative coverage of all the clinical, pharmacological, and technical issues surrounding the use of mechanical ventilation. More than 100 authors, all of whom are at the forefront of research in their... read more

Principles And Practice of Mechanical Ventilation

Predictors of Intubation in Patients With AHRF Treated With a Noninvasive Oxygenation Strategy

In patients with acute hypoxemic respiratory failure breathing spontaneously, the respiratory rate was a predictor of intubation under standard oxygen, but not under high-flow nasal cannula oxygen or noninvasive ventilation.... read more

Predictors of Intubation in Patients With AHRF Treated With a Noninvasive Oxygenation Strategy

ECMO for Severe Middle East Respiratory Syndrome Coronavirus

Extracorporeal membrane oxygenation (ECMO) use, as a rescue therapy, was associated with lower mortality in MERS patients with refractory hypoxemia. The results of this, largest to date, support the use of ECMO as a rescue... read more

ECMO for Severe Middle East Respiratory Syndrome Coronavirus

High Frequency Percussive Ventilation Increases Alveolar Recruitment in Early ARDS

High frequency percussive ventilation (HFPV) combines diffusive (high frequency mini-bursts) and convective ventilation patterns. Benefits include enhanced oxygenation and hemodynamics, and alveolar recruitment, while providing... read more

High Frequency Percussive Ventilation Increases Alveolar Recruitment in Early ARDS

Delayed Intubation Linked to Poor Outcome

The optimal timing of endotracheal intubation in critically ill patients requiring invasive mechanical ventilation remains undefined. A new analysis of the large, prospective Intensive Care Over Nations (ICON) database compares... read more

Delayed Intubation Linked to Poor Outcome

Early Identification of Acute Respiratory Distress Disorder in the Absence of Positive Pressure Ventilation

Almost all patients with pulmonary bilateral infiltrates and a PaO2/FIO2 less than or equal to 300 mm Hg under standard oxygen fulfilled the acute respiratory distress syndrome criteria under noninvasive ventilation within... read more

Early Identification of Acute Respiratory Distress Disorder in the Absence of Positive Pressure Ventilation

Implementation of a Goal-Directed Mechanical Ventilation Order Set Improves Compliance

Implementation of a Goal-Directed Mechanical Ventilation Order Set Driven by Respiratory Therapists Improves Compliance With Best Practices for Mechanical Ventilation. Data regarding best practices for ventilator management... read more

Implementation of a Goal-Directed Mechanical Ventilation Order Set Improves Compliance

Optimal Approach to Mechanical Ventilation After Cardiac Arrest

Return of spontaneous circulation after cardiac arrest results in a systemic inflammatory state called the post-cardiac arrest syndrome (PCAS), characterised by oxidative stress, coagulopathy, neuronal injury, and organ dysfunction.... read more

Optimal Approach to Mechanical Ventilation After Cardiac Arrest

Acute Hypoxemic Respiratory Failure in Immunocompromised Patients

In immunocompromised patients with acute hypoxemic respiratory failure (ARF), initial management aims primarily to avoid invasive mechanical ventilation (IMV). HFNC has an effect on intubation but not on mortality rates.... read more

Acute Hypoxemic Respiratory Failure in Immunocompromised Patients

Workup, Management, and Critical Sequelae of Burn Injuries

Richard Iuorio, MD speaks with Laura Johnson, MD, and Jim Reilly, MD, about the workup, management, and critical sequelae of burn injuries. Using a fictional burn case as an example, Dr. Johnson talks about airway considerations,... read more

Initial Nutritional Management During NIV and Outcomes

Patients starting noninvasive ventilation (NIV) to treat acute respiratory failure are often unable to eat and therefore remain in the fasting state or receive nutritional support. Nearly three-fifths of patients receiving... read more

Initial Nutritional Management During NIV and Outcomes

Corticosteroid Therapy for Critically Ill Patients with the MERS

Corticosteroid therapy in patients with Middle East Respiratory Syndrome (MERS) was not associated with a difference in mortality after adjustment for time-varying confounders, but was associated with delayed MERS coronavirus... read more

Corticosteroid Therapy for Critically Ill Patients with the MERS

Excess Ventilation in COPD-Heart Failure Overlap

Heightened neural drive promoting a ventilatory response beyond that required to overcome an increased "wasted" ventilation led to hypocapnia and poor exercise ventilatory efficiency in chronic obstructive pulmonary disease–heart... read more

Excess Ventilation in COPD-Heart Failure Overlap

Hospital Factors May Influence NIV Outcomes Even in Low-Evidence Use

Strong evidence supports use of noninvasive ventilation (NIV) for patients with respiratory distress from chronic obstructive pulmonary disease and heart failure – i.e., strong evidence conditions (SECs). A new study of... read more

Hospital Factors May Influence NIV Outcomes Even in Low-Evidence Use

Enteral vs. Parenteral Early Nutrition in Ventilated Adults with Shock

In critically ill adults with shock, early isocaloric enteral nutrition did not reduce mortality or the risk of secondary infections but was associated with a greater risk of digestive complications compared with early isocaloric... read more

Enteral vs. Parenteral Early Nutrition in Ventilated Adults with Shock

Furosemide in the Treatment of Acute Pulmonary Edema

CHF is a common problem in the US with over 5 million patients carrying the diagnosis and 500,000 new diagnoses each year.1 Cardiogenic acute pulmonary edema (APE) occurs when blood backs up into the pulmonary vasculature... read more

Furosemide in the Treatment of Acute Pulmonary Edema

Continuing Rehabilitation After ICU Discharge

This article discusses technological innovations that promote survival and enhance recovery, starting within the ICU with developments in ventilation, sedation, early mobility and ICU design. Post-ICU, the establishment of... read more

Continuing Rehabilitation After ICU Discharge

Face Mask vs Helmet for Noninvasive Ventilation

In Reply Drs Taccone and Chiumello state that physicians must understand the helmet’s physiologic behavior in terms of CO2 rebreathing to ensure safety. Neurological impairment led to intubation in 5 of the 8 intubated... read more

Face Mask vs Helmet for Noninvasive Ventilation

Drug does not significantly reduce duration of mechanical ventilation for COPD patients

Among mechanically ventilated patients with COPD, administration of the respiratory stimulant acetazolamide did not significantly reduce the duration of invasive mechanical ventilation.... read more

Drug does not significantly reduce duration of mechanical ventilation for COPD patients