Propranolol decreases in-hospital mortality and improves long-term functional outcome in isolated severe Traumatic Brain Injury (TBI).

This randomized trial speaks in favor of routine administration of beta-blocker therapy as part of a standardized neurointensive care protocol.

219 randomized patients of whom 45% received BB were analyzed.

There were no significant demographic or clinical differences between BB+ and BB− cohorts.

No significant difference in in-hospital mortality or long-term functional outcome was measured between the cohorts.

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