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Blood Transfusion – Fresh vs. Standard-issue in Critically Ill Pediatric Patients

Blood Transfusion – Fresh vs. Standard-issue in Critically Ill Pediatric Patients

Among critically ill pediatric patients, the use of fresh red blood cells did not reduce the incidence of new or progressive multiple organ dysfunction syndrome (including mortality) compared with standard-issue red blood cells.

Among 1,538 patients who were randomized, 1461 patients (95%) were included in the primary analysis, in which there were 728 patients randomized to the fresh red blood cell group and 733 to the standard-issue group.

The median storage duration was 5 days in the fresh group vs 18 days in the standard-issue group.

The primary outcome measure was new or progressive multiple organ dysfunction syndrome, measured for 28 days or to discharge or death.

CriticalCare.news
January 30, 2020

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