Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe hemorrhage

thelancet.com November 8, 2017

Antifibrinolytics reduce death from bleeding in trauma and post-partum haemorrhage. We examined the effect of treatment delay on the effectiveness of antifibrinolytics. We obtained data for 40,138 patients from two randomised trials of tranexamic acid in acute severe bleeding (traumatic and post-partum haemorrhage). Overall, there were 3,558 deaths, of which 1,408 (40%) were from bleeding.