A 2020 randomized trial reported no difference in duration of time alive and free of vasopressor administration at 7 days among intensive care unit (ICU) patients with septic shock assigned to vitamin C, thiamine, and hydrocortisone vs those assigned to hydrocortisone alone.

In this recorded presentation, Tomoki Fujii, PhD, of Monash University in Melbourne, Australia, and Kyoto University Graduate School of Medicine in Japan, presented findings from the VITAMINS Trial at the Critical Care Reviews 2020 meeting (CCR20), on January 17 in Belfast, Northern Ireland.

An oral editorial from Paul Marik, MD, of East Virginia Medical School and a Q&A session follow.

In this randomized clinical trial that included 216 patients with septic shock, treatment with intravenous vitamin C, hydrocortisone, and thiamine, compared with intravenous hydrocortisone alone, did not significantly improve the duration of time alive and free of vasopressor administration over 7 days (122.1 hours vs 124.6 hours, respectively).

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