the TEMP‐CARE trial will advance our understanding of post‐cardiac arrest care fever management strategies. With a large sample size and a broad patient population, the results of this trial will inform clinical practice guidelines and have the potential to improve outcomes for unconscious survivors of out‐of‐hospital cardiac arrest (OHCA).

The TEMP‐CARE trial is part of the 2 × 2 × 2 factorial Sedation, TEmperature and Pressure after Cardiac Arrest and REsuscitation (STEPCARE) trial, a randomized, international, multicenter, parallel‐group, investigator‐initiated, superiority trial that will evaluate sedation strategies, temperature management, and blood pressure targets simultaneously in nontraumatic/nonhemorrhagic out‐of‐hospital cardiac arrest patients following hospital admission.

For the temperature management component of the trial described in this protocol, patients will be randomly allocated to fever management with or without a feedback‐controlled temperature control device.

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