Tag: bacteria

Upvote Story 7
When you enter the hospital, probably the last thing that you’re thinking about is the floors. However, an emerging body of research suggests that hospital floors are covered with bacteria and could serve as a potential source of infection. Even if people don’t directly touch the floors, other things that patients, visitors, and staff routinely touch are in contact with the floor. Thus, it’s a... Read More | Comment
Upvote Story 10
The use of digestive and oral decontaminants in patients in the intensive care unit (ICU) who are mechanically ventilated and who have moderate to high antibiotic resistance is not associated with a reduction in ICU-acquired bloodstream infections caused by multidrug-resistant gram-negative bacteria. According to the results of a randomized clinical trial conducted by investigators in the Netherlands and published in the Journal of the American... Read More | Comment
Upvote Story 6
Copper is a powerful antimicrobial with rapid, broad-spectrum efficacy against bacteria and viruses, and has been shown to kill disease-causing pathogens, including influenza A, E.coli and norovirus, and resistant bacteria including Methicillin-resistant Staphylococcus aureus (MRSA), Carbapenem-resistant Enterobacteriaceae (CRE) and Vancomycin-resistant enterococcus (VRE). It shares this benefit with a range of copper alloys—such as brasses and bronzes—forming a family of materials collectively called ‘antimicrobial copper’. Antimicrobial... Read More | Comment
Upvote Story 5
Scientists have discovered a bacteria ‘alarm clock’ that wakes dormant Salmonella in the body, allowing the bug to trigger a repeat infection. The researchers, from Imperial College London, say the ‘alarm clock’ is shared among different types of bacteria—including Salmonella and E. coli. The findings may explain why some people suffer repeated bouts of infections—for instance ear or urinary tract infections—despite taking antibiotics. The team... Read More | Comment
Upvote Story 5
Researchers conducted a review of the effects of corticosteroids given in addition to antibiotics to children with septic arthritis. Evidence was sought until April 2018. After searching for all relevant studies, reviewers found two studies with 149 children. These studies were conducted in hospitalized children with a normal immune system between the ages of three months and 18 years living in Costa Rica and Israel.... Read More | Comment
Upvote Story 6
Scientists have pinpointed a molecule that accelerates the evolution of drug-resistant microbes. Now they’re trying to find a way to block it. The British chemist Leslie Orgel reputedly once said that “evolution is cleverer than you are.” This maxim, now known as Orgel’s Second Rule, isn’t meant to imply that evolution is intelligent or conscious, but simply that it’s inventive beyond the scope of human... Read More | Comment
Upvote Story 15
In this multicentre study, we could not demonstrate any difference between Lp299 and CHX used in oral care procedures regarding their impact on colonisation with emerging potentially pathogenic enteric bacteria in the oropharynx and trachea. Potentially pathogenic enteric bacteria not present at inclusion were identified in oropharyngeal samples from 29 patients in the CHX group and in 31 samples in the probiotic group. One hundred... Read More | Comment
Upvote Story 5
Ahsan Akram and colleagues have created a fluorescent imaging probe that can quickly and accurately detect hard-to-trace Gram-negative bacteria (one of the major bacterial groups) in human lungs within minutes. Their first-in-human study, where they successfully used the imaging tool to safely detect infections in hospital patients undergoing ventilation, could streamline the diagnosis of bacterial lung infections and more accurately assess if antibiotics are needed.... Read More | Comment
Upvote Story 5
The study by Wittekamp and colleagues in this issue of JAMA evaluating strategies for decontamination of mechanically ventilated patients in the intensive care unit (ICU) fills an important gap in the evidence regarding these practices. Since the first use of selective decontamination of the digestive tract (SDD) in critically ill patients in the 1980s, the effectiveness of this approach to prevent ICU-acquired infections and reduce... Read More | Comment
Upvote Story 19
A superbug resistant to all known antibiotics that can cause “severe” infections or even death is spreading undetected through hospital wards across the world, scientists in Australia warned on Monday. Researchers at the University of Melbourne discovered three variants of the multidrug-resistant bug in samples from 10 countries, including strains in Europe that cannot be reliably tamed by any drug currently on the market. The... Read More | Comment
Upvote Story 5
Nonsusceptibility to first-line antibiotics is associated with decreased survival in GNBSIs. DTR is a simple bedside prognostic measure of treatment-limiting coresistance. The Premier Database was analyzed for inpatients with select GNBSIs. DTR was defined as intermediate/resistant in vitro to all ß-lactam categories, including carbapenems and fluoroquinolones. Between 2009–2013, 471 (1%) of 45011 GNBSI episodes at 92 (53.2%) of 173 hospitals exhibited DTR, ranging from 0.04%... Read More | Comment
Upvote Story 6
Bacterial cells have an added layer of protection, called the cell wall, that animal cells don't. Assembling this tough armor entails multiple steps, some of which are targeted by antibiotics like penicillin and vancomycin. Now researchers have provided the first close-up glimpse of a protein, called MurJ, which is crucial for building the bacterial cell wall and protecting it from outside attack. Read More | Comment
Upvote Story 7
The hospital environment is a source of pathogen transmission. The effect of enhanced disinfection strategies on the hospital-wide incidence of infection has not been investigated in a multicentre, randomised controlled trial. Enhanced terminal room disinfection with UV in a targeted subset of high-risk rooms led to a decrease in hospital-wide incidence of C difficile and VRE. Enhanced disinfection overcomes limitations of standard disinfection strategies and... Read More | Comment
Upvote Story 16
In the Procalcitonin Antibiotic Consensus Trial (ProACT), the use of a procalcitonin-guided antibiotic prescription guideline did not result in less exposure to antibiotics than did usual care among patients presenting to the emergency department (ED) with suspected lower respiratory tract infection. Overuse of antibiotics is common in infections of the lower respiratory tract, where bacterial and viral infections manifest similarly. Procalcitonin is a peptide with... Read More | Comment
Upvote Story 13
Another phage therapy success. Bacteria-killing Viruses found in a pond knocked out an antibiotic resistant infection. Management of prosthetic vascular graft infections caused by Pseudomonas aeruginosa can be a significant challenge to clinicians. These infections often do not resolve with antibiotic therapy alone due to antibiotic resistance/tolerance by bacteria, poor ability of antibiotics to permeate/reduce biofilms and/or other factors. Bacteriophage OMKO1 binding to efflux pump... Read More | Comment