Reducing the Global Sepsis Burden: A Positive Legacy for the COVID-19 Pandemic?

Reducing the Global Sepsis Burden: A Positive Legacy for the COVID-19 Pandemic?

ESICM, SCCM, and the GSA published a consensus paper in Intensive Care Medicine, emphasising the importance of recognising that patients critically ill with COVID-19 have viral sepsis, despite some differences from sepsis... read more

Point-of-Care Transcranial Doppler by Intensivists

Point-of-Care Transcranial Doppler by Intensivists

In the unconscious patient, there is a diagnostic void between the neurologic physical exam, and more invasive, costly and potentially harmful investigations. Transcranial color-coded sonography and two-dimensional transcranial... read more

How I Went from Pulmonary Diagnostics and Wellness to System Lung Coordinator

How I Went from Pulmonary Diagnostics and Wellness to System Lung Coordinator

Main Line Health is a multi-hospital health system serving patients in Philadelphia, PA, and its western suburbs. The system has been recognized as among the best in the region by U.S. News & World Report. In 2017, it was... read more

Higher Level of Mobilization Improves Health Status

Higher Level of Mobilization Improves Health Status

In critically ill survivors, achieving higher levels of mobilization, but not increasing the number of active mobilization sessions, improved health status 6 months after ICU admission. The dosage of mobilization in ICU... read more

Textbook of Cardiorenal Medicine

Textbook of Cardiorenal Medicine

This textbook provides a practical and board-driven resource to describe and define the emerging field of cardiorenal medicine. Covering all aspects of the topic with depth and relevance, this groundbreaking reference brings... read more

Tox and Hound – Metal Hydrides

Tox and Hound – Metal Hydrides

We are left with four main scenarios in which arsine gas is produced and/or encountered: aqueous solutions of oxidized arsenic compounds in contact with metals metal arsenides in contact with water/moisture release... read more

Precision Medicine in ARDS

Precision Medicine in ARDS

Acute respiratory distress syndrome (ARDS) is a devastating critical illness that can be triggered by a wide range of insults and remains associated with a high mortality of around 40%. The search for targeted treatment for... read more

A Retrospective Cohort Study of 12,306 Pediatric COVID-19 Patients in the United States

A Retrospective Cohort Study of 12,306 Pediatric COVID-19 Patients in the United States

Children and adolescents account for ~ 13% of total COVID-19 cases in the United States. However, little is known about the nature of the illness in children. The reopening of schools underlines the importance of understanding... read more

Safety of Arterial Catheterization Using the Distal Radial Approach in ICU Management

Safety of Arterial Catheterization Using the Distal Radial Approach in ICU Management

Distal radial approach (DRA) may be a safe option for insertion of a new A-line in the ICU. The study included 20 patients with a median age of 70 (interquartile range (IQR): 58.5–77) years: 10 patients with traumas,... read more

Low Technology, Mild Controlled Hypothermia for Necrotizing Enterocolitis Treatment

Low Technology, Mild Controlled Hypothermia for Necrotizing Enterocolitis Treatment

Low technology, mild controlled hypothermia was feasible, not related to adverse effects, and effective treatment for NEC Modified Bell's Stage II/III. It avoided surgery, bowel perforation, and extensive intestinal resection;... read more

Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Johnson & Johnson Vaccination

Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Johnson & Johnson Vaccination

The initial 12 US cases of Cerebral Venous Sinus (CVST) with thrombocytopenia after Ad26.COV2.S (Janssen/Johnson & Johnson) vaccination represent serious events. This case series may inform clinical guidance as Ad26.COV2.S... read more

Critical Care Nephrology and Renal Replacement Therapy in Children

Critical Care Nephrology and Renal Replacement Therapy in Children

Pediatric critical care nephrology is a complex and highly specialized field, presenting challenges and management strategies that are often quite distinct from those seen in adult practice. Therefore, it is high time... read more

Host Endothelial, Epithelial and Inflammatory Response in ICU COVID-19 Patients

Host Endothelial, Epithelial and Inflammatory Response in ICU COVID-19 Patients

These studies demonstrate that, unlike other well-studied causes of critical illness, endothelial dysfunction may not be characteristic of severe COVID-19 early after ICU admission. Pathways resulting in elaboration of acute... read more

Guidelines on Myocardial Infarction, Novel Therapeutic Targets in Post-infarction Remodelling

Guidelines on Myocardial Infarction, Novel Therapeutic Targets in Post-infarction Remodelling

This Focus Issue on ischaemic heart disease contains the ‘2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management... read more