The Great Escape: How ECMO Weaning Shifts Antibiotic Levels
This case study explores the complex pharmacological landscape of treating a 47-year-old patient with severe renal impairment and pneumonia using ceftazidime–avibactam (CAZ-AVI) while on VA-ECMO support. Researchers... read more
Life After the Pump: Quality of Life in Cardiac Surgery Survivors
Researchers have conducted a major study—the largest of its kind for this specific population—investigating the long-term quality of life (QoL) for patients who survived post-cardiotomy cardiogenic shock (PC-CS). By... read more
Lung Ultrasound in the Critically Ill: The BLUE Protocol
Written by a pioneer in critical care ultrasound, this book discusses the basic technique and "signatures" of lung ultrasound and explains its main clinical applications. The tools and clinical uses of the BLUE protocol,... read more
Beyond the Pressure: Moving Toward Personalized Sepsis Care
In the high-stakes environment of septic shock, the current clinical "gold standard" remains the early initiation of norepinephrine. However, when blood pressure targets aren't met, the next steps often become a pragmatic... read more
Lost in Translation: Unmasking the Silent Struggle of Ineffective Ventilator Efforts
While identifying the subtle timing mismatches between a patient and a ventilator often requires specialized internal monitoring, clinicians can still spot major "asynchronies" by closely watching the flow and pressure curves... read more
The Kidney Crisis: Acute Injury as a Predictor of ICU Survival
This extensive population-level study from Ontario, Canada, analyzed over 480,000 adult ICU admissions to clarify the relationship between Acute Kidney Injury (AKI) and patient outcomes. By utilizing outpatient baseline data... read more
Predicting Sepsis-associated Encephalopathy in Septic ICU Patients with AKI
Researchers developed a simple, interpretable nomogram to predict sepsis-associated encephalopathy (SAE) on day 1 in septic ICU patients who also have acute kidney injury (AKI), using data from the large MIMIC-IV database... read more
Severe Trauma and Sepsis: Organ Damage and Tissue Repair
This book discusses recent progress in organ damage and tissue repair following severe trauma and sepsis. In part 1, it introduces the theory and clinical practice in organ damage. In part 2, it covers all the subjects... read more
Metabolic Acidosis Worsens Cardiac Function and Vasopressor Needs in Septic Shock
In a prospective observational study conducted from January to December 2024 at Hospital de Especialidades No. 14, IMSS, in Veracruz, Mexico, researchers examined the cardiovascular effects of acute metabolic acidemia in... read more
Corrected Serum Calcium Levels Predict 28-Day Death Risk in Sepsis
In a large cohort study utilizing data from 7,627 sepsis patients in the eICU Collaborative Research Database, researchers uncovered a clear U-shaped relationship between corrected serum calcium (sCa) levels and 28-day mortality.... read more
Integration Equals Separation for CRRT Filter Lifespan in ECMO Patients (E-CRRT Trial)
The multicenter randomized controlled E-CRRT Trial, conducted from May 2021 to March 2025 at King Chulalongkorn Memorial Hospital (KCMH) and Central Chest Institute of Thailand (CCIT), compared two strategies for combining... read more
Sepsis: Definitions, Pathophysiology and the Challenge of Bedside Management
A comprehensive and state-of-the-art resource for clinicians who care for patients with sepsis and research scientist alike. Patients with severe sepsis requiring ICU admission have very high rates of ICU and overall... read more
Neostigmine’s Anti-Inflammatory Edge: Cholinergic Boost Slashes Cytokines, Organ Failure, and Mortality in Septic Shock
In a randomized controlled trial, researchers investigated the adjuvant use of continuous neostigmine infusion (0.2 mg/hr for 5 days) in patients with septic shock, leveraging its ability to enhance vagal cholinergic anti-inflammatory... read more
Bedside Procedures for the Intensivist
Bedside Procedures for the Intensivist delivers practical tips and clear, step-by-step instruction on the most common procedures in the ICU. The convenient and portable handbook focuses on ultrasound-guided techniques, including... read more
The Pressure to Survive: Why Peak BP Matters for the Oldest ICU Patients
This binational cohort study analyzed 219 patients aged 90 and older who were admitted to the ICU following an in-hospital cardiac arrest. While clinical focus often shifts to average or minimum blood pressure, this research... read more
The Dangerous Duo: How Delirium Compounds Risks in Acute Kidney Injury
This systematic review and meta-analysis of over 158,000 critically ill patients reveals a significant link between Acute Kidney Injury (AKI) and delirium, affecting approximately 32% of patients with AKI. The study found... read more
Blood Pressure Disorders in Acute and Chronic Kidney Diseases (Updates in Hypertension and Cardiovascular Protection)
This new book is intended to be an in-depth and up-to-date guide to the various aspects of the association between blood pressure disorders and acute/chronic renal diseases. In addition, this work includes discussion... read more
AI Foresees the Squeeze: Machine Learning Predicts Vasopressor Needs Hours Ahead in Sepsis Patients
This proof-of-concept retrospective study, utilizing the MIMIC-IV v2.2 database (2008–2019), demonstrates that an interpretable machine learning model based on routinely collected electronic health record data from ICU... read more
Sepsis Management: PIRO and MODS
This book is unique in approaching multiple organ dysfunction syndrome (MODS) from the perspective of its pathophysiological mechanism, and addressing aspects that are overlooked in most of the available literature. Eminent... read more
Urinary Source Saves Lives: Why Infection Origin Matters in Septic Shock for Patients Over 90
In critically ill nonagenarians and centenarians admitted to ICUs with septic shock, the source of infection emerges as a key independent predictor of long-term survival, varying over time. Patients with septic shock from... read more
Less Steroids, Better Outcomes: High-Dose Corticosteroids Harm ICU COPD Patients
A large pharmacoepidemiologic cohort study of over 17,000 US patients admitted directly to ICUs for acute exacerbations of COPD revealed that two-thirds received high-dose systemic corticosteroids (>240 mg/day methylprednisolone... read more
Obesity Paradox or Myth? BMI Shows No Impact on Sepsis Survival in ICU Patients
This retrospective cohort study examined the association between body mass index (BMI) and clinical outcomes in 559 adult ICU patients with sepsis admitted between January 2021 and December 2023. Patients were categorized... read more
