Beyond the Basics: New Respiratory Markers Predict Extubation Failure
A multicenter study focused on high-risk patients who successfully passed a conventional 30-minute Spontaneous Breathing Trial (SBT) found that standard measures alone are insufficient to predict extubation failure. Extubation... read more
Reducing Mortality in Critically Ill Patients
This book describes the techniques, strategies, and drugs that have been demonstrated by multicenter randomized trials to influence survival in critically ill patients, defined as those who have acute failure of at least... read more
Cost-Effective Care: Pantoprazole Saves Lives and Dollars in the ICU
A groundbreaking study spearheaded by researchers at McMaster University has confirmed that the widespread use of the inexpensive medication pantoprazole not only prevents life-threatening upper gastrointestinal (GI) bleeding... read more
Breadth of Antibiotics Trumps Dose and Duration in Driving ICU Superbugs
In a large prospective cohort study across four ICUs (422 patients enrolled from March 2024 to January 2025), 35.8% of patients acquired carbapenem-resistant Gram-negative bacteria (CR-GNB) during their stay. Using sophisticated... read more
Superbugs Are Winning – Time to Fight Back with the Four-Pillar Plan
The relentless global surge in multidrug-resistant (MDR) infections, vividly illustrated by high rates of carbapenem-resistant Acinetobacter in Western Romania and echoed worldwide, is outpacing outdated diagnostic and treatment... read more
Monitoring Mechanical Ventilation Using Ventilator Waveforms
This book discusses the interpretation of mechanical ventilator waveforms. Each page shows a screenshot from a real patient and explains one or two messages. It starts with basic information about the waveforms and goes... read more
Norepinephrine Usage Tips in Perioperative Medicine
Tip 1. Looking beyond vasodilatation: use norepinephrine as first-line vasopressor but reassess the cause of hypotension before escalation. Tip 2. Set a goal of mean arterial blood pressure above 60 mmHg, and individualize... read more
Predicting Sepsis Mortality: The Power of NLR and PCT Clearance
A retrospective cohort study analyzed the dynamic changes of several inflammatory biomarkers to predict mortality in 64 Intensive Care Unit (ICU) patients diagnosed with sepsis. The study, which collected clinical and... read more
Less Sedation, Shorter Stays: The Benefit of Analgesia-Based Protocols
A retrospective study conducted in a 24-bed medical Intensive Care Unit (ICU) compared patient outcomes before and after implementing a new analgesia-based sedation protocol. The research included 79 patients managed... read more
RealMIP: The AI That Sees Death Coming in Real Time
A groundbreaking new framework called RealMIP finally cracks the long-standing problem of real-time mortality prediction in chaotic ICU data streams riddled with missing values and irregular sampling. By combining cutting-edge... read more
Why the 7-Day IV Change Policy Could Cost Lives and Millions
A new economic evaluation of the landmark RSVP trial reveals that adopting 7-day routine IV replacement (deemed “non-inferior” to every-3-day changes based on acute catheter infection rates) may actually be harmful and... read more
Moderate and Deep Sedation in Clinical Practice
Millions of procedures requiring sedation are performed each year, covering a large array of medical specialties in both inpatient and outpatient settings. This tremendous growth has led to sedation being administered by... read more
Filling the Gap: Non-Drug Interventions After Critical Care
A comprehensive scoping review sought to summarize the current landscape of non-pharmacological interventions aimed at improving patient outcomes following discharge from critical care. From over 41,000 reports screened,... read more
The Pharmacist’s Expanded Role in Critical Care Medicine: A Comprehensive Guide for Practitioners and Trainees
This new book will serve as a useful resource for all pharmacists involved in the management of critically ill patients, whatever their level of experience and training. There are few textbooks aimed specifically at critical... read more
Move Early, Recover Faster: Early Mobilization Slashes ICU Stays Without Adding Risk
An updated systematic review and meta-analysis of 16 high-quality randomized trials (2,385 ICU patients) delivers a clear verdict: starting mobilization within 72 hours of admission is not only safe but powerfully effective.... read more
Steroids Save Lives in Severe Pneumonia and ARDS – Without Spiking Superbug Risk
A rigorous new systematic review and meta-analysis of 20 high-quality trials (3,459 patients) confirms that low-dose, short-course systemic corticosteroids significantly reduce short-term mortality in both severe pneumonia... read more
Ventilator Management: A Pre-Hospital Perspective
The goal of this book is to provide the most up to date information on mechanical ventilation based on current research, evidence based practice and my experiences as a flight paramedic and educator. A comprehensive look... read more
Master the CCRN Exam Without Guesswork: The Proven Study System with 1200+ Questions, 7 Full-Length Tests & Step-by-Step Strategies to Build ICU Confidence, Save Study Time, and Feel Fully Prepared
What If You Could Stop Second-Guessing and Start Walking into the CCRN Exam Fully Prepared and Confident? Are you overwhelmed by the amount of content to memorize—and unsure where to even begin? Does your mind go blank... read more
Optimizing Sedation & Analgesia in the ICU, An Issue of Critical Care Clinics, E-Book (The Clinics: Internal Medicine)
In this issue of Critical Care Clinics, guest editors Drs. Yahya Shehabi, Joanna L. Stollings, and Timothy D. Gerard bring their considerable expertise to the topic of Optimizing Sedation and Analgesia in the ICU. Top... read more
Mastering ICU Care: Algorithms and Clinical Decision-Making for Residents
This book covers all aspects of ICU care, from diagnostics and treatment modalities to patient management. It features real-world case studies and provides step-by-step guidance on critical care. Additionally, it discusses... read more
The POCUS Textbook: Learn Point-of-Care Ultrasound of the Blood Vessels, Heart, & Lungs
Bring your physical exam into the modern era by learning point-of-care ultrasound (POCUS). Learn cardiopulmonary POCUS with step-by-step instructions from Dr. Istrail. Over 100 crystal-clear figures beautifully designed... read more
ICU Protocols: A Step-wise Approach, Vol II
The second edition of this highly successful book includes up-to-date notes on the step-wise management of clinical emergencies encountered in everyday intensive care units (ICU). Each thoroughly revised chapter provides... read more
