Sepsis-3 defines organ dysfunction as an increase in the Sequential Organ Failure Assessment score by greater than or equal to 2 points. However, some Sequential Organ Failure Assessment score components are not routinely... read more

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Variability in pathogenesis and complex pathophysiology often delay diagnosis and create significant challenges for clinical... read more

The association of plasma interleukin-8 (IL-8), or IL-8 genetic variants, with pediatric acute respiratory distress syndrome (PARDS) in children with acute respiratory failure (ARF) at risk for PARDS has not been examined.... read more

In a large cohort study of 55,038 adults hospitalized with sepsis, short-term mortality (death or hospice) was lower in overweight and obese patients compared with those with normal body mass indices (both unadjusted and... read more

Written by experts in the field, Families in the Intensive Care Unit: A Guide to Understanding, Engaging and Supporting at the Bedside is a state-of-the-art reference for all clinicians who work with families in the ICU.... read more

In this physiological study, we report an improvement of respiratory unloading by adding a second level of pressure with NAVA in infants with severe bronchiolitis. WOB decreased immediately after switching to NAVA, as reported... read more

The most popular book at ISICEM meeting. Despite increasing interest in intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) as causes of significant morbidity and mortality among the critically ill,... read more

Although considerable progress has been made over the past decades, some important questions remain relating to the optimal ventilation management in patients with intra-abdominal hypertension (IAH). When looking after patients... read more

This meta-analysis contributes very little to the current discussion mainly because of the heterogeneity of included studies. The use of fluid type in different pathologies isn’t really what we need, but rather tailored... read more

Objective data and expert guidance on managing critically ill patients in unique question-based chapters that focus on best practices. Now thoroughly updated by Drs. Clifford S. Deutschman, Patrick J. Neligan, and nearly... read more

The consideration of acute kidney injury, its incidence and its impact on the outcome of patients has grown continuously in recent years, leading to an increase in the use of renal replacement therapy (RRT) techniques. Recent... read more

Asynchronies are a frequent issue in ventilated patients. They represent a mismatch between the inspiratory and expiratory times of patient and ventilator, and thus a failure to provide ventilated patients with optimal assistance.... read more

ICU is a hotbed of infections and measures are taken to prevent these infections. Ventilator associated pneumonia is one of the Intensive Care Unit related infections. This book tells us what ventilator associated pneumonia... read more

Nearly one in five critically ill children with acute kidney injury (AKI) do not experience increase in serum creatinine. These acute kidney injury events, which are only identified by urine output criteria, are associated... read more

The proportion of CD127lowPD-1high T cells in patients was increased compared with healthy volunteers, although no global CD127 regulation was observed. Our results suggest that TCR activation participates in the occurrence... read more

LANGE Critical Care delivers concise, evidenced-based, and highly clinical coverage of the surgical and medical aspects of critical care. The book provides basic fundamentals, applications and insights that will be of lasting... read more

The EXACT protocol: a multi-centre, single-blind, randomised, parallel-group, controlled trial to determine whether early oxygen titration improves survival to hospital discharge in adult OHCA patients. This study will determine... read more

Both children and parents have alarmingly high rates of acute stress and posttraumatic stress following the child’s PICU admission. Although family function did not emerge as a predictor in this study, further understanding... read more

Sharpen your critical care skills, with the fully updated Quick Reference to Critical Care, fifth 5th edition. This well-illustrated pocket guide covers the full range of critical care scenarios, listing each disorder, medication,... read more

In-hospital cardiac arrest is common and associated with a high mortality rate. Despite this, in-hospital cardiac arrest has received little attention compared with other high-risk cardiovascular conditions, such as stroke,... read more

We often assume that diagnostic procedures will help patients. A lot of training goes into learning how to do these procedures. Procedures are dramatic. We like performing them. Patients are impressed, perceiving that we... read more

This pocket book succinctly describes 318 errors commonly made by attendings, residents, interns, nurses, and nurse-anesthetists in the intensive care unit, and gives practical, easy-to-remember tips for avoiding these errors.... read more

Ceftolozane-tazobactam (C/T), the combination of a new cephalosporin with a classic β-lactamase inhibitor, is currently considered the most active betalactam antibiotic against P. aeruginosa. Despite several case reports... read more