Corticosteroid Treatment and Survival in Critically Ill COVID-19 Patients

Our multinational study identified three distinct clinical COVID-19 phenotypes, each exhibiting marked differences in demographic, clinical, and immunological features, and in the response to late and short-term corticosteroid... read more

Tags: corticosteroids, COVID-19, cytokine, inflammation, mechanical ventilation, phenotypes, study, treatment,

Cytokine Storm Syndrome

Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of... read more

Tags: book, coronavirus, COVID-19, education, infection, research,

Long-term Effects of Flexible Visitation in the ICU on Patients’ Mental Health

Flexible ICU visitation, compared to the restrictive visitation, was associated with a significant reduction in the 1-year prevalence of post-traumatic stress symptoms in family members. A total of 519 family members were... read more

Tags: anxiety, depression, family, ICU, PTSD, stress, study,

Conservative or Liberal Oxygen Targets in Patients on VA-ECMO

In adults receiving VA-ECMO in the ICU, a conservative compared to a liberal oxygen strategy did not affect the number of ICU-free days to day 28, nor any other measurable patient outcomes up to 6 months after ICU admission.... read more

Tags: cardiogenic shock, ECMO, hyperoxemia, ICU, oxygen, oxygenation, treatment, trial, vasoconstriction, ventilation, ventilator,

Oxygen Therapy in Acute Hypoxemic Respiratory Failure

Although largely used, the place of oxygen therapy and its devices in patients with acute hypoxemic respiratory failure (ARF) deserves to be clarified. The French Intensive Care Society (Société de Réanimation de Langue... read more

Tags: ARF, edema, hypoxemia, oxygen, oxygen therapy, oxygenation,

Evidence-Based Critical Care: A Case Study Approach

This book provides learners with a unique opportunity by virtue of the format outlined above. Each case presentation has a case vignette, which leads up to an important clinical question, and is followed by additional discussion... read more

Tags: book, education, ICU, study, therapy,

ICU Cardiac Arrest Among Very Elderly Critically Ill Patients

The occurrence of ICU-CA in critically ill patients with advanced age (≥ 90 years) is relatively rare. The observed mortality in the ICU and hospital was exceedingly high. Notably, providing cardiopulmonary resuscitation... read more

Tags: cardiac arrest, CPR, ICU, IHCA, mechanical ventilation, SOFA, study,

Platelet Transfusions: Ten Things ICU Specialists Need to Know

Thrombocytopenia is common in critically ill patients and is associated with higher bleeding risk and worse outcomes. Platelet transfusions are frequently used to prevent or treat bleeding, though often with uncertain benefits... read more

Tags: bleeding, blood, platelet, thrombocytopenia, transfusion,

Critical Care Nephrology and Renal Replacement Therapy in Children

Pediatric critical care nephrology is a complex and highly specialized field, presenting challenges and management strategies that are often quite distinct from those seen in adult practice. Therefore, it is high time to... read more

Tags: AKI, book, diagnosis, nephrology, RRT, treatment,

Optimal Antibiotic Treatment Duration of Upper and Lower Respiratory Tract Infections

The available evidence for non-ICU community-acquired pneumonia (CAP) and chronic obstructive pulmonary disease (AECOPD) supports a short-course treatment duration of 5 days in patients who have clinically improved. Efforts... read more

Tags: antibiotics, CAP, COPD, ICU, infection, pneumonia, treatment,

Outcomes of ECMO in ARDS in Pediatric Trauma Patients

Among children who suffer from acute respiratory distress syndrome (ARDS) complications following trauma, the use of extracorporeal membrane oxygenation (ECMO) failed to show any association with mortality benefit. More studies... read more

Tags: ARDS, ECMO, pediatrics, sepsis, study, trauma,

Army Scientists’ Technique for Early Sepsis Detection in Burn Patients Submitted to FDA

A new invention developed at the U.S. Army Medical Research and Development Command uses an artificial intelligence machine learning algorithm to identify whether burn patients are at risk of experiencing life-threatening... read more

Tags: biomarkers, diagnosis, FDA, ICU, infection, inflammation, sepsis, technology,

ECLS in Cardiogenic Shock Complicating Acute Myocardial Infarction: Benefit and Harm

Cardiogenic shock is a critical condition that affects up to 10% of patients hospitalized with acute myocardial infarction (AMI), representing the primary cause of death in this group. Recently, frequentist analysis showed... read more

Tags: AMI, cardiogenic shock, ECLS, myocardial infarction, treatment, trial,

Long-term Outcomes in Nutrition Trials

Survivors of critical illness frequently suffer from physical, cognitive and mental disorders after hospital discharge, leading to increased disabilities, poor quality of life, and worse long-term outcomes. Therefore, different... read more

Tags: disability, ICU, nutrition, study,

Systemic Corticosteroids for Inflammatory Disorders in Pediatrics

This comprehensive volume provides current state of the art of the use of corticosteroids in the pediatric patient. It consists of 14 chapters written by leading authors from different countries. The first chapters cover... read more

Tags: book, corticosteroids, inflammation, pediatrics, treatment,

Impact of the Timing of Invasive Mechanical Ventilation in Sepsis Patients

In patients with sepsis admitted to ICU and received invasive mechanical ventilation (MV), early MV was associated with lower ICU and in-hospital mortality and a shorter ICU stay. Additionally, at ICU discharge, early MV... read more

Tags: ARDS, ARF, COVID-19, HFNC, ICU, mechanical ventilation, pneumonia, sepsis, SOFA, ventilation,

Early sodium bicarbonate therapy for critically ill patients with septic shock and acute moderate metabolic acidosis

In recent decades, septic shock has continued to be a life-threatening health problem around the world. Meanwhile, metabolic acidosis (MA) is also well known in critically ill patients, and even moderate metabolic acidosis... read more

Tags: acidosis, AKI, guidelines, ICU, infection, sepsis, septic shock,

Trauma: My Life as an Emergency Surgeon

TRAUMA is Dr. Cole’s harrowing account of his life spent in the ER and on the battlegrounds, fighting to save lives. In addition to his gripping stories of treating victims of gunshot wounds, stabbings, attempted suicides,...

The Harriet Lane Handbook: Mobile Medicine Series

Written “by residents, for residents” and reviewed by expert faculty at The Johns Hopkins Hospital, Lauren Kahl, MD and Helen K. Hughes, MD, MPH, The Harriet Lane Handbook, 21st Edition, remains your #1 source...