COVID-19 Patients with ARDS Face Significant Financial Effects in Recovery
Long hospitalizations lead to large medical bills, with serious physical and emotional consequences for those recovering from critical illness. It begins with shortness of breath. And for approximately one-third of patients,... read more
WHO Resumes Hydroxychloroquine Study for COVID-19
The World Health Organization is resuming a clinical trial exploring whether the malaria drug hydroxychloroquine can effectively treat COVID-19, after pausing enrollment in the study to review safety concerns about the drug. The... read more
The Perils of Premature Phenotyping in COVID-19
The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) poses an unprecedented global healthcare challenge. Severe novel Coronavirus disease (COVID-19) pneumonia frequently causes hypoxemic respiratory failure, manifesting... read more
Blood Vessel Attack Could Trigger Coronavirus’ Fatal Second Phase
Frank Ruschitzka told his pathologist to be ready before the first COVID-19 patient died. In early March, Ruschitzka, who leads the cardiology department at University Hospital Zürich, noticed that patients with the disease... read more
What’s Next for EDs in the COVID-19 Pandemic?
As of late May, most countries have falling numbers of new cases of COVID-19 and are at various stages of easing lockdown orders. This seems a good time to look back on the pandemic experience so far and at what lessons we... read more
Functional Disability 5 Years After ARDS
Exercise limitation, physical and psychological sequelae, decreased physical quality of life, and increased costs and use of health care services are important legacies of severe lung injury. At 5 years, the median 6-minute... read more
What COVID-19 Has Taught Me
A personal narrative of Adrian Wong’s experience while battling COVID-19 at King's College Hospital. These are the author's personal opinions and do not represent the views of the institution and professional societies... read more
Near Death in the ICU
A phenomenal collection of medical patient accounts of encounters with the mysterious during severe illness and life-threatening injury from the voice of the physician who took care of them. Both touching and thought-provoking,... read more
Are Phenotypes a Magic Bullet for Sepsis?
There's a constant battle in medicine between practice styles—standardization and customization. Standardization is order sets and doing the same thing for every patient every time because it (hopefully) delivers better... read more
Corticosteroids for Critically Ill COVID-19 Patients with Cytokine Release Syndrome
Approximately 5% of coronavirus disease (COVID-19) patients will require admission to an intensive care unit (ICU). Among these patients, the most severe cases may be mediated by a late-onset systemic inflammatory response... read more
Prolonged Prone Position Ventilation for SARS-CoV-2 Patients is Feasible and Effective
Recently, novel coronavirus 2019 (nCOV-19) is spreading all around the world causing severe acute respiratory syndrome (SARS-CoV-2) requiring mechanical ventilation in about 5% of infected people. Prone position ventilation... read more
Predictors of Care in Persons Under Investigation for COVID-19
The healthcare burden of the coronavirus disease 2019 (COVID-19) pandemic extends beyond patients who test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), according to a retrospective cohort study... read more
How to Intubate the Critically Ill Like a Boss
Despite decades of experience with endotracheal intubation, we continue to find approaches to improving the process of how we intubate. In today's post we are not only going to talk about how to avoid post intubation cardiac... read more
Remdesivir 5-day vs. 10-day Trial Raises Some Red Flags?
Gilead's first Randomized Controlled Trial on remdesivir was just published, and it's very interesting. This is a trial designed, monitored, and written by Gilead. In some ways, the design of the trial and its missing parts... read more
Urge Congress to Ensure that Emergency Physicians Have Due Process Rights
H.R. 6910, critical bipartisan legislation to ensure every emergency physician has medical staff due process rights was recently introduced by emergency physician and member of Congress, Rep. Raul Ruiz, MD (D-CA), and Rep.... read more
ICU Isolation Hood Decreases Risk of Aerosolization During Noninvasive Ventilation with COVID-19
The treatment of patients with coronavirus disease (COVID-19) needs to take into consideration not only the disease process but also the availability of medical resources and the risks of transmission to healthcare providers.... read more
Spontaneous Echo Contrast in Venous Ultrasound of Severe COVID-19 Patients
Initial reports have indicated a higher incidence of venous thromboembolism (VTE) among patients with coronavirus disease 2019 (COVID-19) compared to other critical illnesses. Helms et al. found pulmonary embolisms in 25%... read more
Long-Term Health-Related Quality of Life After Venovenous Extracorporeal Membrane Oxygenation
This study examined the long-term health-related quality of life in adult patients treated with venovenous extracorporeal membrane oxygenation (V-V ECMO) for severe acute respiratory failure in Ireland. A retrospective, cross-sectional... read more
Is Locoregional Anesthesia a Functional Option for Major Abdominal Surgeries in the COVID-19 Era?
Based on our preliminary case series, awake open surgery has resulted feasible and safe. This approach has allowed to perform undelayable major abdominal surgeries on fragile patients when intensive care beds were not available.... read more
International PICU COVID-19 Collaboration Conference Call
This episode is an international collaborative conference call hosted by Dr. Jeffrey Burns of Boston Children's Hospital and Harvard Medical School. Featured speakers are Drs. Daniel Barouch, Trevor Duke, and Robinder Khemani,... read more
First Report on a First-in-Human Clinical Trial of a Novel Ad5 Vectored COVID-19 Vaccine
This is the first report on a first-in-human clinical trial of a novel Ad5 vectored COVID-19 vaccine. The Ad5 vectored COVID-19 vaccine was tolerated in healthy adults in all three dose groups. The most common adverse... read more
Phenotypic Heterogeneity by Site of Infection in Surgical Sepsis
There are notable differences in baseline predisposition, host responses, and clinical outcomes by site of infection in surgical sepsis. While previous studies have focused on differences in hospital mortality, this study... read more
