Supporting the Shielded – Results from a National Survey of Shielding Doctors
In spring, NHS staff responded to the looming COVID-19 pandemic with an impressive level of strategic planning. As operating theatres closed and ICU beds were created, anaesthetists and intensivists faced new challenges on... read more
COVID-19 and AKI
Recent reports from China, Italy, and the US indicate that there is a 25-37% incidence of AKI among critically ill COVID-19 patients (Singh 2020, Hirsch et al. 2020). In a study of 5,449 hospitalized COVID-19 patients, acute... read more
What is the Diagnostic Accuracy of Antibody Tests for the Detection of Infection with the COVID-19 Virus?
The sensitivity of antibody tests is too low in the first week since symptom onset to have a primary role for the diagnosis of COVID-19, but they may still have a role complementing other testing in individuals presenting... read more
A Systematic Review of Risk Factors for Sleep Disruption in Critically Ill Adults
This systematic review summarizes all premorbid, illness-related, and ICU-related factors associated with sleep disruption in the ICU. These findings will inform sleep promotion efforts in the ICU and guide further research... read more
Together: The Healing Power of Human Connection in a Sometimes Lonely World
The book we need NOW to avoid a social recession, Murthy’s prescient message is about the importance of human connection, the hidden impact of loneliness on our health, and the social power of community. Humans are social... read more
The Case for Routine Screening for COVID-19 Before Surgery
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 5 million cases of coronavirus disease (COVID-19) worldwide and 345,000 deaths as of 25 May 2020. Based on accumulating international experience... read more
Perhaps something isn’t always better than nothing
It is not unreasonable to say the COVID-19 pandemic caught most of us by surprise. We did not know how infectious the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) virus leading to COVID-19 disease was, nor... read more
From despair to hope: advanced therapy gives a lifeline to the sickest COVID-19 patients
More than two months later, that piece of paper still lies on her coffee table with four letters on it: "E-C-M-O." Irena Veronese had never heard that acronym before, but when it was first mentioned to her, it meant moving... read more
Effect of Dexamethasone in Hospitalized Patients with COVID-19
Although the paper is not even officially published yet, everyone has already heard the results. We have our first treatment that appears to reduce mortality in COVID-19 patients. For a week or so, we only had press release,... read more
Hydrocortisone Prevents Immunosuppression by interleukin-10+ Natural Killer Cells After Trauma-Hemorrhage
These data demonstrate that trauma-induced immunosuppression is characterized by an interleukin-10-dependent elimination of dendritic cell by natural killer cells and that hydrocortisone improves outcome by limiting this... read more
Procedural Sedation in the COVID-19 Era
Resuming procedural sedation services for elective procedures during the COVID-19 pandemic requires unique considerations to ensure safety for patients and providers. Guidelines for resuming these procedures, including timing,... read more
What’s the Difference Between COVID-19 Tests?
The COVID-19 pandemic, tests, treatments, and outlook, continue to be front and center in the news, along with other urgent issues taking place across the country. Viral sepsis is the number one complication related to... read more
Exhaled Air Dispersion During Bag-mask Ventilation and Sputum Suctioning
Mask ventilation and coughing during oro-tracheal suctioning produce aerosols that enhance nosocomial transmission of respiratory infections. We examined the extent of exhaled air dispersion from a human-patient-simulator... read more
The Relevance of Thromboinflammation and Endothelial Dysfunction in COVID-19 Patients
The relevance of thromboinflammation and endothelial dysfunction in COVID-19 patients. Microvascular derangement is a key mechanism of multiple organ dysfunction and therapeutic strategies other than heparin, aimed at preserving... read more
