Adult Critical Care Medicine
This clinical casebook provides a comprehensive yet concise state-of-the-art review of adult critical care medicine. Presented in a case-based format, each case focuses on a scenario commonly encountered with an adult patient... read more
Major Cardiovascular Surgery-induced Metabolic Reprogramming Role in AKI
Major cardiovascular surgery, particularly with cardiopulmonary bypass (CPB), induces significant changes in protein metabolism. Patients developing postoperative acute kidney injury (AKI) exhibited specific metabolic signatures.... read more
Ventilation Practices in ABI Patients and Association with Outcomes
Current mechanical ventilation practices for patients with acute brain injury (ABI) are poorly defined. This study aimed to describe ventilator settings/parameters used in intensive care units (ICUs) and evaluate their association... read more
Cardiovascular Complications of COVID-19: Acute and Long-Term Impacts
This book is the first comprehensive approach on COVID-19 cardiac complications, both during the acute phase as well as in the long-COVID period. It provides an up-to-date and highly illustrated summary of the biology... read more
Standard vs. Double Dosing of Beta-lactam Antibiotics in Critically Ill Sepsis Patients
The BULLSEYE trial is a randomized controlled study designed to enhance the treatment of critically ill patients with septic shock. The concept of administering higher and double doses of beta-lactams in such patients... read more
PCR and Biomarker Algorithms to Guide Antibiotics in Lower Respiratory Tract Infections
Acute chest syndrome (ACS) in sickle cell disease (SCD) is life-threatening and characterised by a new infiltrate on imaging plus fever or respiratory symptoms.1 Causes of ACS include infections, venous or fat embolisms or... read more
Unsupervised Multi-modal ML Approach for Robust CPR Signal Denoising
The significance of denoising biomedical signals, particularly in crucial life-saving interventions like cardiopulmonary resuscitation (CPR), cannot be overstated, as the accuracy and reliability of CPR data can be a matter... read more
NHF Oxygen During Apnoea on Hypoxemia and Intubation Success in Pediatric Emergency and ICU
The use of nasal high-flow (NHF) during emergency intubation in children did not result in a reduction in hypoxemic events or an increase in the frequency of successful intubation on the first attempt. However, in the... read more
Blood Glucose and Clinical Outcomes After ECC
Postoperative blood glucose levels significantly impact outcomes in cardiac surgery patients undergoing extracorporeal circulation (ECC) auxiliary to open heart surgery. The study's primary outcome was the 90-day mortality,... read more
Respiratory Monitoring in Mechanical Ventilation: Techniques and Applications
This book covers the up-to-date advancement of respiratory monitoring in ventilation support as well as detecting the physiological responses to therapeutic interventions to avoid complications. Mechanical ventilation nowadays... read more
Helmet CPAP as NIV for COVID-19 Patients
The COVID-19 pandemic has challenged healthcare systems globally, highlighting the need for effective respiratory support strategies. Helmet continuous positive airway pressure (CPAP) has emerged as a potential noninvasive... read more
Tracheostomy in COVID-19 Patients
Tracheostomy is common in critically ill COVID-19 patients. In patients predicted to need a tracheostomy at some point, early, rather than late, tracheostomy might be a means to reduce the time spent in ICU. However,... read more
Pirfenidone to Prevent Fibrosis in ARDS
Pulmonary fibrosis is a major complication of the Acute Respiratory Distress Syndrome (ARDS). Pirfenidone is an approved treatment for idiopathic pulmonary fibrosis. It may attenuate ARDS-related fibrosis and decrease the... read more
Association Between Osteopontin and Apolipoprotein E gene Polymorphisms and Vancomycin-induced AKI
Individuals carrying specific genotypes of APOE (e2e3) were more prone to develop vancomycin-induced acute kidney injury (AKI), per se. This could apply to other nephrotoxic agents as well. We also observed a significant... read more
Severe COVID-19 Early Identification and the Need for ICU Care Based on Objective Risk Factors
The study found that several factors, including advanced age; male gender; and comorbid conditions like diabetes, chronic lung disease, and CVD had a strong association with ICU admission among COVID-19 patients. Similarly,... read more
Point-of-Care Ultrasound for the Neonatal and Pediatric Intensivist: A Practical Guide on the Use of POCUS
This book, written by internationally renowned experts, is a comprehensive text covering all aspects and recommendations regarding the use of POCUS for critically ill neonates and children. Point of Care Ultrasound (POCUS)... read more
Septic Distributive Shock: Resuscitative Endovascular Balloon Occlusion of the Aorta
Massive distributive shock can lead to total collapse of the cardiopulmonary system with a subsequent need for CPR. Partial REBOA may be a viable resuscitation adjunct in such cases to restore hemodynamics and increase coronary... read more
ISCCM Manual of RRT and ECMO in ICU: A Reference Book for Practicing Intensivists
The topics were chosen to make the reader understand comprehensive management of therapies including organization, communication and other administrative issues including cost-effective therapies. This will help the practicing... read more
Lactate Trajectory Models for Predicting AKI and Mortality in Hyperlactatemia Patients
The present study underscores the significant prognostic value of lactate trajectories in critically ill patients, particularly those with hyperlactatemia. Our findings suggest that rapid lactate clearance is strongly... read more
Mortality Time Frame Variability in Septic Shock Clinical Trials
There was considerable variability in the mortality time frames reported in ICU-based septic shock trials. This variability may lead to under or overestimation of the problem, overlooking the effectiveness of the interventions... read more
Hemophagocytic Lymphohistiocytosis Markers Associated with Mortality in Critically Ill Patients
The present study highlights the prognostic significance of HLH criteria in critically ill patients. Individuals exhibiting two or more criteria at ICU admission experienced nearly a doubling in mortality as compared to patients... read more
COVID-19 vs non-COVID-19 Patients Without Hematological Malignancies Treated for Invasive Pulmonary Aspergillosis
COVID-19-associated pulmonary aspergillosis (CAPA) patients have less comorbidities and higher fungal burden compared to Putative Invasive Pulmonary Aspergillosis (PIPA), but clinical outcomes are similar between groups.... read more
