Long-term survival in patients with septic acute kidney injury is strongly influenced by renal recovery
In patients with sepsis, recovery by hospital discharge is associated with long-term survival similar to patients without AKI. Of the 1742 patients who survived to hospital discharge, stage 2–3 AKI occurred in 262 (15%),... read more
The Effect of Diaries Written by Relatives for ICU Patients on PTSD
The results of this study will inform ICU nurses about the effects, strengths and limitations of prompting relatives to author a diary for the patient. This will allow the diary intervention to be tailored to the individual... read more
A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients
Critically ill patients have considerable oxidative stress. Glutamine and antioxidant supplementation may offer therapeutic benefit, although current data are conflicting. In this blinded 2-by-2 factorial trial, we randomly... read more
Running an RCT – A Conversation With the Investigators of the REGAIN Trial
It is easy for armchair activists to bash randomized controlled trials (RCTs) with clever methodological critiques. However, it takes a lot of effort and coordination to pull off an RCT successfully. In this episode of Radiology... read more
Mortality and Cardiovascular and Respiratory Morbidity in Individuals with Impaired FEV1 (PURE)
The associations between the extent of forced expiratory volume in 1 s (FEV1) impairment and mortality, incident cardiovascular disease, and respiratory hospitalisations are unclear, and how these associations might vary... read more
Use of the Confusion Assessment Method in Multi-center Delirium Trials
Delirium occurs commonly in older adults and is associated with adverse outcomes. Multi-center clinical trials evaluating interventions to prevent delirium are needed. The Confusion Assessment Method (CAM) is a validated... read more
The Evolution of Lung Protective Ventilation in ARDS
Dr. Jesus Villar is Group Chief of the Center for Biomedical Research in Respiratory Diseases in Madrid and Senior Scientist of the Research Unit at the Hospital Universitario Dr. Negrin in Las Palmas, Spain. He is the Coordinator... read more
Loss of Sphingosine 1-Phosphate in Septic Shock is Predominantly Caused by Decreased Levels of HDL
Sphingosine 1-phosphate (S1P) is a signaling lipid essential in regulating processes involved in sepsis pathophysiology, including endothelial permeability and vascular tone. Serum S1P is progressively reduced in sepsis patients... read more
A Pilot Study Evaluating the Effect of Cooler Dialysate Temperature on Hemodynamic Stability During Prolonged Intermittent RRT in AKI
Acute kidney injury (AKI) requiring renal replacement therapy (RRT) is associated with high morbidity and mortality. Complications of renal replacement therapy include hemodynamic instability with ensuing shortened treatments,... read more
CRRT for Sepsis-induced Acute Kidney Injury
Sepsis-induced acute kidney injury (SI-AKI) represents the first cause of AKI in ICUs, and renal replacement therapy (RRT) is frequently applied in advanced AKI stages. The debate between 'rescue' indications for RRT start... read more
Evidence Backs Giving Probiotics with Antibiotics
So much of what we're told to do calls for sweeping practice changes or titanic additions to our routine approach. My own articles have advocated for tremendous shifts in typical techniques, and one need not look far to find... read more
No-Shitters, Boldface, and the Resus QRH
In an amazing lecture; Joe Novak, ED doc and former combat aviator; spoke about the need for memorized boldface actions and then the availability of a quick reference handbook (QRH) for the next steps. But where are either... read more
Optimizing Beta-Lactam Treatment in the ICU
The French Society of Pharmacology and Therapeutics (SFPT) and the French Society of Anesthesia and Intensive Care Medicine (SFAR) have released guidelines on the optimization of beta-lactam treatment in intensive care unit... read more
Repeated Ambulance Use is Associated with Chronic Diseases
There is a growing demand for emergency medical services (EMS) and patients are repeatedly transported by ambulance services. For many patients, especially those with chronic disease, there may be better ways of delivering... read more
Critical Care Nursing – Diagnosis and Management
Get a firm understanding and mastery of the unique issues and procedures involved in critical care nursing with Critical Care Nursing: Diagnosis and Management, 8th Edition. Praised for its comprehensive coverage and clear... read more
Antibiotics for Sepsis – Finding the Equilibrium
Sepsis is medicine’s last remaining preserve for unrestrained antibiotic prescribing. The Surviving Sepsis Campaign guidelines recommend empirical broad-spectrum therapy within one hour of triage for both sepsis and septic... read more
Low Hand Hygiene Compliance in ICUs
Healthcare workers in intensive care units (ICUs) are regularly missing opportunities to clean their hands during the care of patients, despite its critical importance for infection control, according to new research being... read more
Going Into Hospital Far Riskier Than Flying
Millions of people die each year from medical errors and infections linked to health care and going into hospital is far riskier than flying according to World Health Organization. If you were admitted to hospital tomorrow... read more
Catheter Type in Pulmonary Embolism Intervention
Catheter based interventions for pulmonary embolism is on the rise. The rise in mainly in patients who present with submassive PE. The intent of intervention is to reduce clot burden. This is done to improve acute symptoms... read more
What is the lowest change in cardiac output that transthoracic echocardiography can detect?
In critically ill patients, changes in the velocity-time integral (VTI) of the left ventricular outflow tract, measured by transthoracic echocardiography (TTE), are often used to non-invasively assess the response to fluid... read more
Flu Killed Up to 54,800 People This Season
The flu has caused as many as 40.1 million illnesses and 54,800 deaths this season, according to CDC estimates based on the agency's most recent FluView report. During the 2017-18 flu season, an estimated 80,000 people died.... read more
Hyperinvasive approach to out-of hospital cardiac arrest using mechanical chest compression device
Authors introduce and offer a protocol of a proposed randomized study enrolling patients with witnessed OHCA presumably of cardiac origin planned to be initiated in Prague in 2012. Study will compare hyperinvasive approach... read more
