AI Can Predict Sepsis to Save Lives

Emory University researchers have created a "Sepsis Expert" algorithm that works in real time to predict the onset of sepsis, the deadly condition that often takes hold in healthcare settings. Banking on information from... read more

All Things Flu

Dr. Christopher Carroll and Dr. Jayshil Patel discussing all things flu on Reddit. They provide the facts, share the latest in research and help provide more information on how to best tackle this flu season. We are in the... read more

Risk Factors for Ventilator-Associated Events in a PICU

There is an association between ventilator-associated condition and infection-related ventilator-associated complication in critically ill children with acute kidney injury, ventilatory support, and neuromuscular blockade.... read more

Association of ICH Among Patients Taking Non–Vitamin K Antagonist vs Vitamin K Antagonist Oral Anticoagulants With In-Hospital Mortality

Among patients with ICH, prior use of NOACs or warfarin was associated with higher in-hospital mortality compared with no OACs. Prior use of NOACs, compared with prior use of warfarin, was associated with lower risk of in-hospital... read more

Differential Diagnosis Between Newly Diagnosed Asthma and COPD Using EBC Metabolomics

Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous diseases with high pathological burden and healthcare costs. In the outpatient clinical practice, an accurate differential diagnosis is often very... read more

Early Application of APRV May Reduce the Duration of Mechanical Ventilation in ARDS

Compared with LTV, early application of airway pressure release ventilation (APRV) in patients with ARDS improved oxygenation and respiratory system compliance, decreased Pplat and reduced the duration of both mechanical... read more

Advanced Hemodynamic and Cardiopulmonary Ultrasound for Critically Ill Patients

Focused echocardiography, advanced hemodynamic, and cardiopulmonary point-of-care ultrasound studies provide time-sensitive evaluation of critically ill patients, guiding and facilitating earlier implementation of life-preserving... read more

Managing Sepsis and Septic Shock Current Guidelines and Definitions

While sepsis defies simple definition, it's generally understood to be a clinical syndrome caused by infection that may have profound adverse physiologic consequences. Although its precise incidence is unknown, sepsis is... read more

Differences in Impact of Definitional Elements on Mortality Precludes International Comparisons of Sepsis Epidemiology

Within a sepsis cohort, we illustrate case-mix heterogeneity using definitional elements (infection source and organ dysfunction). In the context of improving outcomes, we illustrate differential secular trends in impact... read more

Monitoring ICU Performance-impact of a Novel Individualised Performance Scorecard in Critical Care Medicine

Patients admitted to a critical care medicine (CCM) environment, including an intensive care unit (ICU), are susceptible to harm and significant resource utilisation. Therefore, a strategy to optimise provider performance... read more

Enteral vs Parenteral Nutrition in Critical Care Requiring Mechanical Ventilation

Enteral feeding was not superior to parenteral feeding for early nutritional support in critically ill patients receiving mechanical ventilation and vasopressor support for shock, according to the results of a study published... read more

Prospective Evaluation of a Multifaceted Intervention to Improve Outcomes in Intensive Care

Studies comprehensively assessing interventions to improve team communication and to engage patients and care partners in ICUs are lacking. This study examines the effectiveness of a patient-centered care and engagement program... read more

Liberal Glycemic Control in Critically Ill Patients With Type 2 Diabetes

Ludwig Lin, MD, speaks with Palash Kar, MBBS, about the article, "Liberal Glycemic Control in Critically Ill Patients With Type 2 Diabetes: An Exploratory Study," published in Critical Care Medicine. In this article, Dr.... read more

Factors Associated with Life-Sustaining Treatment Restriction in the ICU

Few previous studies have investigated associations between clinical variables available after 24 hours in the ICU and decisions to restrict life-sustaining treatment. The aim of this study was to identify factors associated... read more

Ultrasonography in Trauma: a Nation-wide Cross-Sectional Investigation

The Focused Assessment with Sonography in Trauma (FAST) protocol is considered beneficial in emergent evaluation of trauma patients with blunt or penetrating injury and has become integrated into the Advanced Trauma Life... read more

The ADRENAL Trial: Steroids in Septic Shock

Randomized clinical trials evaluating the efficacy of adjunctive corticosteroids in septic shock have shown conflicting evidence of clinical relevance. Two trials in particular looked at lower dose hydrocortisone (200mg/day)... read more

Enabling Machine Learning in Critical Care

Critical care units are home to some of the most sophisticated patient technology within hospitals. In parallel, the field of machine learning is advancing rapidly and increasingly touching our lives. To facilitate the adoption... read more

What have been the major recent advances in delirium research and care?

Editor-In-Chief-Elect Giuseppe Citerio discusses the recent article focused on the intensive care delirium research agenda in Intensive Care Medicine (ICM). For this evidence-based paper, a multinational and inter-professional... read more

Barriers and Facilitators to Early Rehabilitation in Mechanically Ventilated Patients

Using a theoretically driven approach, this study identified important barriers and facilitators to early rehabilitation in ICU patients. In particular, the domains of social influences and behavioral regulation were not... read more

Defining Sepsis on the Wards: Comparing Two Sepsis Definitions

Sepsis is defined as a dysregulated host response to infection, resulting in acute organ dysfunction. Although the condition has been thoroughly studied in the intensive care unit (ICU), accurate data collection outside of... read more

How Patient Stories Can Improve Intensive Care

Opportunities to share stories about care, in settings away from the hospital, serve to bridge the gap between the experiences of patients and those of doctors and nurses. The 21st century re-orientation of health care towards... read more

Supplemental Parenteral Nutrition vs. Usual Care in Critically Ill Adults

This individually titrated supplemental PN strategy applied over 7 days significantly increased energy delivery when compared to usual care delivery. Clinical and functional outcomes were similar between the two patient groups.... read more