Use of ‘tidal volume challenge’ to improve the reliability of pulse pressure variation
Fluid loading is usually the first step in the resuscitation of patients with acute circulatory failure. Fluid responsiveness is defined as the ability of the left ventricle to increase its stroke volume in response to fluid... read more
Acute Kidney Injury is not Associated with IV Contrast Use in the ED
Intravenous (IV) iodinated contrast media is used routinely to improve the accuracy of computed tomography (CT) in the emergency department (ED). Prior studies have linked contrast media with the development of acute kidney... read more
THRIVE Developments
The THRIVE initiative is proud to announce the selection of 10 institutions to a new Post Intensive Care Unit (ICU) Clinic Collaborative. The purpose of the THRIVE Post ICU Clinic Collaborative is to build an international... read more
Relative Bradycardia in Patients With Septic Shock Requiring
Relative bradycardia in patients with septic shock is associated with lower mortality, even after adjustment for confounding. Our data support expanded investigation into whether inducing relative bradycardia will benefit... read more
Pre-hospital therapeutic hypothermia: The RINSE trial
Therapeutic hypothermia has had a bit of a rollercoaster ride over the last few years. It was all the rage following three small trials, which initially suggested a significant benefit from cooling patients to 33C following... read more
EM-Critical Care: Aortic Dissection
Thoracic Aortic Dissection A difficult to diagnose, uncommon, and potentially fatal condition: Emergency Medicine at its finest! Let’s talk about a patient we think see every day in the ED. A man comes in complaining... read more
Intraoperative Oxidative Stress Associated With Postoperative Delirium
Intraoperative oxidative stress is associated with postoperative delirium in ICU patients after cardiac surgery, a study has found. Researchers from Vanderbilt University Medical Center, in Nashville, Tenn., came to this... read more
Anesthesiologists Found Underreporting Medication Errors
Medication errors are apparently significantly underreported by anesthesia providers, at least at certain institutions. These recent findings may reflect a culture of underreporting or fear of punitive action, despite the... read more
Meta-analysis confirms EGDT for sepsis is unhelpful and wasteful (PRISM)
Three large, well-conducted randomized trials around the world (ProCESS, ARISE, and ProMISe) all agreed: use of early goal-directed therapy (EGDT) for sepsis does not improve mortality or any other important clinical outcome.... read more
2017’s Tell-All Social Media Guide for Doctors and Hospitals
You may have thought "this too shall pass", but now you’ve realized the inevitable truth: social media is here to stay. If you’ve never given social media much thought when it comes to your physician practice... read more
ICU Study Shows Significant Reduction in Time to Blood Gas Result using Sphere Medical’s Proxima
A recent time and motion study by University Hospital Southampton demonstrated a 1.5 minute (>20%) reduction in time to blood gas results when using the Proxima bedside blood gas monitoring system. The study also found... read more
The Sick and the Dead: Evidence-Based Trauma Resuscitation
The science of trauma resuscitation has undergone a fairly massive evolution in the past decade. This talk was our attempt to summarize the best-of-the-best in trauma literature from the past several years, and package it... read more
Early, Goal-Directed Therapy for Septic Shock
After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. This... read more
How Redesigning The Abrasive Alarms Of Hospital Soundscapes Can Save Lives
After a recent hospital stay filled with frightening, uselessly beeping gadgets, an ambient musician set to work reinventing the aural landscape of medicine, to make life calmer for patients and easier for doctors. ... read more
The Case for CRISPR-Cas9
Few techniques in the history of modern science have made as large an impact in as short a time as CRISPR-Cas9. Only a few years after the technique was first described, its inventors are predicted to be on the shortlist... read more
Drug-Free Musculoskeletal Pain Therapy Given Clearance by FDA
BioElectronics Corp. has received over-the-counter use market clearance from the FDA for ActiPatch for the adjunctive treatment of musculoskeletal pain related to plantar fasciitis of the heel and osteoarthritis of the knee. BioElectronics... read more
How to keep up with the scientific literature
Few aspects of scientific work may be as crucial - and yet as easy to neglect - as reading the literature. Beginning a new research project or writing a grant application can be good opportunities for extensive literature... read more
