Bacterial molecule trains the immune system to tolerate infection without inducing illness
Pathogen infection has been considered to have one of two general outcomes - either the infected organism develops some level of illness or its immune system fights off and eliminates the invading pathogen.... read more
Adjunctive azithromycin reduces risk of non-elective cesarean post-operative infection: The C/SOAP trial
Women receiving azithromycin in addition to standard antibiotic prophylaxis for cesarean section (c-section) were 49% less likely to develop endometritis and postoperative wound infections compared to those who received only... read more
Use of Evidence-Based Medical Therapy Steadily Improving in Acute MI Patients Postdischarge
Over a recent 10-year period, there has been an improvement in the prescription of evidence-based medical therapy for patients who survive and are discharged from hospital after an MI, a new analysis shows.... read more
Researchers identify genes that may cause gum disease
Columbia University scientists say they have identified 41 master regulator genes that may cause gum disease in a first-of-its-kind study.... read more
Frontline PARP inhibitor shrinks tumors in BRCA-positive breast patients
All 13 newly diagnosed breast cancer patients with BRCA mutations had their tumors shrink significantly when treated with a PARP inhibitor ahead of frontline presurgical chemotherapy in a pilot study at The University of... read more
New Ecosystem Test Strongly Predicts Ovarian Cancer Survival
Assessing the cell ecosystems at sites where ovarian cancer has spread round the body strongly predicts the chances of surviving from the disease, a new study reports. ... read more
New Treatment Guidelines for Rare Lung Disease
Clinical practice guidelines created for the treatment and diagnosis of lymphangioleiomyomatosis (LAM).... read more
Use of interventions improves patient care for viral hepatitis
Researchers recommend multiple, inexpensive interventions be included in screening, diagnosis and treatment programs for patients with hepatitis B and C viruses, in an effort to optimize the outcomes of hepatitis care.... read more
Hydrocortisone and Septic Shock in Patients With Severe Sepsis
This randomized clinical trial compares the effects of hydrocortisone vs placebo on development of septic shock among intensive care patients with severe sepsis who were not in septic shock.... read more
Rivaroxaban associated with increased bleeding risk compared with dabigatran in nonvalvular atrial fibrillation
There was a total of 52 240 new starts of dabigatran and 66 651 new starts of rivaroxaban during the study period. Rivaroxaban was associated with a non-significant decrease in thromboembolic stroke. There was also a non-significant... read more
Transcranial direct current stimulation enhances cognitive training in Parkinson’s
Transcranial direct current stimulation plus cognitive training may produce the best cognitive results in Parkinson’s patients with mild cognitive impairment. tDCS adds cognitive benefit when combined with cognitive training... read more
Gene could lead to ALS therapies
Researchers from Ben-Gurion University of the Negev say their new gene study could lead to new treatments for amyotrophic lateral sclerosis, or ALS.... read more
Glycemic control, mortality, and hypoglycemia in critically ill patients: a systematic review and network meta-analysis of randomized controlled trials
Network meta-analysis showed no mortality benefit of tight glycemic control in critically ill patients, but fivefold more hypoglycemia versus mild or very mild control.... read more
Urine test may detect Creutzfeldt-Jakob disease
Researchers at the Medical Research Council in Britain have discovered it may be possible to test patients for Creutzfeldt-Jakob disease using urine samples.... read more
Should we treat pyrexia? And how do we do it?
Pyrexia has long been thought of as a protective physiological response to help host defences, although this is now being challenged. Despite recent advances, it remains unclear whether pyrexia or the physiological response... read more
Increasing survival after admission to UK critical care units following cardiopulmonary resuscitation
In recent years there have been many developments in post-resuscitation care. We have investigated trends in patient characteristics and outcome following admission to UK critical care units following cardiopulmonary resuscitation... read more
Association of Sodium Selenite and Procalcitonin-Guided Therapy With Mortality
This randomized clinical trial evaluates the use of high-dose sodium selenite, with or without use of a procalcitonin algorithm to guide therapy, and its association with mortality in patients with severe sepsis.... read more
