Methylene Blue Reduced Length of Stay in ICU
In patients with septic shock, methylene blue (MB) initiated within 24 h reduced time to vasopressor discontinuation and increased vasopressor-free days at 28 days. It also reduced length of stay in ICU and hospital without... read more
ECMO in Adult Patients Receiving HCT
Combined advances in hematopoietic cell transplantation (HCT) and intensive care management have improved the survival of patients with hematological malignancies admitted to the intensive care unit. In cases of refractory... read more
Hospital Acquired Infections, Multidrug Resistant (MDR) Bacteria, Alternative Approaches to Antibiotic Therapy
Bacterial resistance to known and currently used antibiotics represents a growing issue worldwide. It poses a major problem in the treatment of infectious diseases in general and hospital-acquired infections in particular.... read more
Post-discharge Care Using Telemedicine: Pre-pandemic vs. Pandemic Care
Expansion of virtual post-discharge visits to include all patients and telephone calls did not negatively impact rates of 30-day post-discharge hospital encounters. Offering tele-health options for post-discharge follow-up... read more
Targeted Immunomodulation: A Primer for Intensivists
Targeted immunomodulation is a topic that gained wide interest from translational researchers in the past decades, yet immunomodulatory drugs were not frequently administered to intensive care patients. The coronavirus... read more
Is It Time to Abandon Routine Mask Ventilation Before Intubation?
Mask ventilation in the period between induction and intubation has traditionally been used to confirm the ability to ventilate the patient while awaiting the onset of adequate neuromuscular blockade. However, recent studies... read more
Impact of Variations in the Nursing Care Supply-Demand Ratio on Postoperative Outcomes and Costs
Improving surgical outcomes is a priority during the last decades because of the rising economic health care burden. The adoption of enhanced recovery programs has been proven to be part of the solution. In this context,... read more
Acute Lung Injury and Repair: Scientific Fundamentals and Methods
Acute Respiratory Distress Syndrome (ARDS) remains an important cause of morbidity and mortality worldwide, and the incidence is predicted to increase with the aging population. Several clinical disorders can initiate... read more
Spotlight on Aortic Stenosis and Dissection
This Focus Issue on valvular heart disease contains the State of the Art Review article "ESC/EACTS vs. ACC/AHA guidelines for the management of severe aortic stenosis" by Grace Lee from the Temerty Faculty of Medicine in... read more
The High-risk Surgical Patient
It is well known that certain diseases and patient conditions are associated with increased perioperative risk. The aim of this book is to define and identify the clinical factors that warrant a broader and more detailed... read more
Continuous Positive Airway Pressure Usage During COVID-19
We confirm that use of early continuous positive airway pressure (CPAP) with high-flow output combined with an "ad hoc" algorithm to inform the decision to intubate is a valid and safe strategy for respiratory support in... read more
Mechanical Power: Meaning, Uses and Limitations
Ventilator-induced lung injury (VILI) carries significant attributable mortality in acute respiratory distress syndrome (ARDS). Even though all the ventilatory variables contribute to VILI, current guidelines focus almost... read more
Cardiovascular Mortality Post Burn Injury
Survivors from burn injury, especially young males, are at increased long-term risk of death from cardiovascular disease. Increased screening and counseling pertaining to lifestyle factors should be standard management post-burn... read more
Dexmedetomidine, Almost As Many Uses As There Are Letters
There is literature to support the use of dexmedetomidine in patients with sympathomimetic toxidrome. It may be a reasonable approach to utilize Dex, with or without a bolus, while closely monitoring these patients in an... read more
Postoperative Pulmonary Complications in the ENIGMA II Trial
Respiratory complications remain among the most common and serious adverse outcomes of major surgery. In the Australian and New Zealand Audit of Surgical Mortality, postoperative pneumonia accounted for 44% of infective... read more
COVID-19 Treatment Guidelines New Version Published
The COVID-19 Treatment Guidelines Panel (the Panel) is pleased to announce the publication of an updated version of the Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. In the United States, the prevalence of... read more
Intensive Care in Nephrology
The field of intensive care in nephrology is a rapidly evolving one, with research starting to translate into clinical guidelines and standards. Encompassing core subjects in critical care and nephrology, as well as specific... read more
Interim Clinical Treatment Considerations for Severe Manifestations of Mpox
The Centers for Disease Control and Prevention (CDC) released a Morbidity and Mortality Weekly Report (MMWR) titled "Interim Clinical Treatment Considerations for Severe Manifestations of Mpox—United States, February 2023."... read more
Sick Children Identification in Acute Care Settings
At the heart of every pediatric consultation is the clinician’s responsibility to determine ‘is this child sick?’ In pediatrics illustrative language communicates a clinical picture of the child before us. When... read more
Loved Ones Are Not “Visitors” in a Patient’s Life
Hospitals are institutions whose primary task is to treat patients. Family-centered care, which considers loved ones as equal partners in patient care, has been gaining recognition in the adult care setting. Our aim was... read more
Bempedoic Acid Associated with Lower Risk of Cardiovascular Events
Among statin-intolerant patients, treatment with bempedoic acid was associated with a lower risk of major adverse cardiovascular events (death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or... read more
The CLOVERS Trial: Does Nothing Matter in Sepsis?
The CLOVERS trials is an open label RCT that did not demonstrate any difference (beneficial or harmful) from using a restrictive fluid strategy over a liberal fluid strategy in sepsis-induced hypotension. Do whatever... read more
