Regular Old Pneumonia Treatment Just Got Better
In 2020, COVID-19 pneumonia became so common that "old-fashioned" bacterial pneumonia suddenly seemed rare. They look very different on x-ray. See if you can spot the differences. A new study from France tipped the scales... read more
Early Calorie and Protein Restriction Associated with Faster Recovery in Ventilated Patients
Compared with standard calorie and protein targets, early calorie and protein restriction did not decrease mortality but was associated with faster recovery and fewer complications. Of 3,044 patients randomly assigned... read more
Hydrocortisone in Severe Community-Acquired Pneumonia
Among patients with severe community-acquired pneumonia being treated in the ICU, those who received hydrocortisone had a lower risk of death by day 28 than those who received placebo. A total of 800 patients had undergone... read more
COVID-19 in Solid Organ Transplant Recipients
Solid Organ Transplant (SOT) recipients are at high risk of severe coronavirus disease-2019. Prior to the availability of vaccination, passive immunotherapies and effective antiviral therapeutics, the outcomes of COVID-19... read more
Optimal Bundle of Recommendations for Sepsis
The aim of this retrospective cohort study was to identify among the Surviving Sepsis Campaign (SSC) guidelines the optimal bundle of recommendations that minimize 28-day mortality. The bundle of six recommendations is... read more
Clinical Cases in Critical Care
In Clinical Cases in Critical Care, the authors explore core clinical topics and basic sciences in a practical and realistic way, and include comprehensive discussions focusing on critically unwell patients with a variety... read more
Elevated BMI Impact on Burn Injury
This study confirms a U-shaped association between body mass index and burn-related mortality along with age, total burn surface area, full-thickness burns, and comorbidities as risk factors. The study included 9,405 adult... read more
No Benefits For Using 4-Factor Prothrombin Complex Concentrate (4F-PCC) in Trauma Patients
Early administration of 4-factor prothrombin complex concentrate (4F-PCC) was of no benefit to patients with trauma at risk of massive transfusion, the randomized PROCOAG trial from France showed. Among over 300 patients... read more
ICU Precision Diagnosis with Metagenomic Sequencing
Despite promising results, metagenomics remains underutilized in the ICU. Several factors still limit its inclusion in routine critical care, including the lack of definitive clinical trials testing its utility, few laboratories... read more
Strategies for Mechanical Ventilation in Patients with Brain Injury
Although direct data to guide mechanical ventilation in brain-injured patients is accumulating, the current evidence base remains limited. Ventilatory considerations in this population should be extrapolated from high-quality... read more
Multifaceted Early Mobility Intervention Impact for Critically Ill Children
This study will examine whether a multifaceted strategy to optimize early mobility affects the duration of mechanical ventilation, delirium incidence, and functional outcomes in critically ill children. This study will... read more
Overcoming Mental Health Stigma For Nurses
What’s the first thought that comes to mind when you think about mental illness? Is it something negative? If so, it probably comes from the stigma associated with mental health. A stigma is defined as "a mark of disgrace... read more
Practical Trends in Anesthesia and Intensive Care 2020-2021
This book offers an essential guide to managing the most-debated hot topics of practical interest in anesthesia and intensive care. Part I reviews the state of the art in issues concerning both intensive care medicine... read more
Polymorphism in Interferon Alpha/Beta Receptor Contributes to Glucocorticoid Response and Outcome of ARDS and COVID-19
The distribution of this SNP within clinical study arms may explain the contradictory results of multiple ARDS studies and outcomes in COVID-19 concerning type I IFN signaling and glucocorticoids. We found a novel disease... read more
COVID-19 Pandemic Effect on the Incidence and Survival Outcomes of EMS-witnessed OHCA
While other international studies have observed higher incidence and reduced survival in non-EMS-witnessed out-of-hospital cardiac arrest (OHCA) during the COVID-19 pandemic, this study did not identify any significant impacts... read more
Effect of ICU Quality Control Indicators on VAP Incidence Rate and Mortality
This study highlights the association between the ICU quality control (QC) factors and ventilator-associated pneumonia (VAP) incidence rate and mortality. The process factors rather than the structural factors need to be... read more
PLASMIC Score Role in the Management of Thrombotic Thrombocytopenic Purpura
At centers that are resource-limited and where ADAMTS-13 testing is not readily available, it is imminent that treatment is started immediately based on the clinical presentation and PLASMIC score. A PLASMIC score can... read more
Improving Intubation Performance with Airway Registries
Airway registries are used as a crucial tool to monitor and improve intubation performance and patient care. ED airway registries inform and document the efficacy of quality improvement initiatives to improve intubation performance... read more
Oral PCSK9 Inhibitor Could Help Reduce LDL-C by 60%
New research from a phase 2b trial presented at American College of Cardiology meeting (ACC) 2023 suggests an oral PCSK9 inhibitor could help reduce LDL-C by 60% in patients with or at-risk for atherosclerotic cardiovascular... read more
Advances in Microbiology, Infectious Diseases and Public Health: Volume 15
This book series focuses on current progress in the broad field of medical microbiology, and covers both basic and applied topics related to the study of microbes, their interactions with human and animals, and emerging issues... read more
Heparin-based vs. Bivalirudin-based Anticoagulation in Pediatric ECMO
Bivalirudin may be a safe, cost-effective alternative to heparin in achieving anticoagulation in pediatric extracorporeal membrane oxygenation (ECMO) patients. Prospective multicenter studies and randomized control trials... read more
IHCA Variation Throughout the Day
We observed higher rates of hospital cardiac arrest (IHCA), and poorer outcomes at night. However, in those admitted to ICU, this variation was absent. This suggests patient factors and processes of care issues contribute... read more
