Sepsis: Definitions, Pathophysiology and the Challenge of Bedside Management

Sepsis: Definitions, Pathophysiology and the Challenge of Bedside Management

A comprehensive and state-of-the-art resource for clinicians who care for patients with sepsis and research scientist alike. Patients with severe sepsis requiring ICU admission have very high rates of ICU and overall... read more

Long COVID Associated with Reduced Circulating Serotonin Levels

Long COVID Associated with Reduced Circulating Serotonin Levels

Post-acute sequelae of COVID-19 (PASC, "Long COVID") pose a significant global health challenge. The pathophysiology is unknown, and no effective treatments have been found to date. Several hypotheses have been formulated... read more

COVID-19-associated Sepsis: Incidence and Mortality

COVID-19-associated Sepsis: Incidence and Mortality

In this retrospective cohort study of hospitalized adults, SARS-CoV-2 accounted for approximately 1 in 6 cases of sepsis during the first 33 months of the COVID-19 pandemic. In-hospital mortality rates for SARS-CoV-2–associated... read more

ECLS in Infarct-Related Cardiogenic Shock

ECLS in Infarct-Related Cardiogenic Shock

In patients with acute myocardial infarction complicated by cardiogenic shock with planned early revascularization, the risk of death from any cause at the 30-day follow-up was not lower among the patients who received ECLS... read more

Levels of Intensive Care vs. In-Hospital Mortality in Patients Hospitalized for Sepsis Stratified by SOFA

Levels of Intensive Care vs. In-Hospital Mortality in Patients Hospitalized for Sepsis Stratified by SOFA

Patients hospitalized for sepsis with Sequential Organ Failure Assessment (SOFA) scores greater than or equal to 6 in the ICU or HDU had lower in-hospital mortality than those in the general ward, as did those with SOFA scores... read more

Enteral Citrulline Supplementation vs. Placebo in Mechanically Ventilated Patients

Enteral Citrulline Supplementation vs. Placebo in Mechanically Ventilated Patients

Among mechanically ventilated ICU patients without sepsis or septic shock, enteral L-citrulline administration did not result in a significant difference in SOFA score on day 7 compared to placebo. Of 120 randomized patients... read more

Mechanical Ventilation in Patient with Respiratory Failure

Mechanical Ventilation in Patient with Respiratory Failure

This handbook covers the principles of mechanical ventilation, making them easy to understand and apply in clinical settings. Presented in an accessible style and supplemented by a wealth of illustrations and graphs, it includes... read more

Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU

Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU

In critically ill patients who were not receiving early parenteral nutrition, tight glucose control did not affect the length of time that ICU care was needed or mortality. Of 9,230 patients who underwent randomization,... read more

Roadblock: AFib with RVR

Roadblock: AFib with RVR

In this paper we focus on strategies to bypass the most common pitfalls in our treatment algorithm when treating patients who present to the ED in atrial fibrillation with RVR. We all know the few medications in our toolbox... read more

What to Know About Merkel Cell Carcinoma, the Rare Cancer that Killed Jimmy Buffett

What to Know About Merkel Cell Carcinoma, the Rare Cancer that Killed Jimmy Buffett

"Margaritaville" singer Jimmy Buffett died of Merkel cell carcinoma, a rare but aggressive form of skin cancer, according to a tribute posted on his official websiteopens in a new tab or window. The 76-year-old music icon... read more

The Hemodynamics of Adrenal Veins with Four-dimensional CT Using Quantitative Time-density Curve

The Hemodynamics of Adrenal Veins with Four-dimensional CT Using Quantitative Time-density Curve

Present study quantitatively analyzed adrenal venous flow using four-dimensional computed tomography (4D CT). We reviewed 4D CT images of 55 patients [mean age, 52 years ± 11 (standard deviation); 23 females] who underwent... read more

Urine Output-based Sepsis-associated AKI: Clinical Implications

Urine Output-based Sepsis-associated AKI: Clinical Implications

This paper offers comprehensive insights into the epidemiology of acute kidney injury (AKI), and we commend the authors for their significant contribution. They revealed an increase in the number of mild cases among AKI stage... read more

Acute Undifferentiated Fever with Thrombocytopenia: Clinical and Etiological Profile

Acute Undifferentiated Fever with Thrombocytopenia: Clinical and Etiological Profile

Prompt recognition and management of thrombocytopenia in acute undifferentiated fever are vital. Thrombocytopenia, along with organ dysfunction and shock, significantly influence patient outcomes. Tailored interventions based... read more

A Beginner’s Guide to Vasopressors: Inodilators, Inopressors, Methylene Blue, Midodrine: An Essential Manual to Understanding Cardiac Medications and Cardiovascular Hemodynamic Mechanics

A Beginner’s Guide to Vasopressors: Inodilators, Inopressors, Methylene Blue, Midodrine: An Essential Manual to Understanding Cardiac Medications and Cardiovascular Hemodynamic Mechanics

The use of pressors and dilators are common in intensive care units, especially concerning the heart. With different mechanisms of action and titrations, it is essential to know how each of the drugs perform and the potential... read more