Balanced Opioid-free Anesthesia with Dexmedetomidine vs. Balanced Anesthesia with Remifentanil for Noncardiac Surgery
This trial refuted the hypothesis that balanced opioid-free anesthesia with dexmedetomidine, compared with remifentanil, would result in fewer postoperative opioid-related adverse events. Conversely, it did result in a greater... read more
Enhancing anti-tumour efficacy with immunotherapy combinations
Several tumour types are responsive to immunotherapy, as shown by regulatory approvals for immune checkpoint inhibitors. However, many patients either do not respond or do not have durable clinical benefit. Thus, there... read more
Prophylaxis for Pneumocystis Pneumonia in non‐HIV Immunocompromised Patients
Our review shows that TMP/SMX prophylaxis is highly effective for prevention of Prophylaxis for Pneumocystis Pneumonia (PCP) in patients with hematological malignancies, bone marrow transplantation and solid organ transplantation,... read more
Study Finds Lower Dose of Ketamine Equally Effective in Reducing Pain
Ketamine is known to provide pain relief comparable to opioid medications, which are highly addictive. In the recent study, appearing in the journal Academic Emergency Medicine, researchers studied 98 patients, ages 18 to... read more
Early Mobilization of Patients Receiving Vasoactive Drugs in Critical Care Units
Evidence determining specific doses of vasoactive drugs that would allow safe mobilization of patients in critical care is lacking. The criteria that have been used to determine the eligibility to mobilize patients on vasoactive... read more
Bridging the Gap Between Intensivists and Primary Care Clinicians in ECMO for Respiratory Failure in Children
All pediatric clinicians should be aware not only of the potential benefits and complications of ECMO but also that survivors need effective screening, support, and follow-up. The 2009 influenza A(H1N1) pandemic, along... read more
Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial
In critically ill mechanically ventilated patients, early sedation with dexmedetomidine exhibited a high probability of reduced 90-day mortality in older patients regardless of operative or non-operative cluster status. Conversely,... read more
Body Mass Index and Risk for COVID-19
Obesity* is a recognized risk factor for severe COVID-19, possibly related to chronic inflammation that disrupts immune and thrombogenic responses to pathogens as well as to impaired lung function from excess weight. Obesity... read more
Convalescent Plasma Doesn’t Prevent Further COVID-19 Progression in At-Risk Patients
Convalescent plasma (CP) from recovered patients with COVID-19 doesn't prevent further COVID-19 progression in at-risk people who visit the emergency room (ER). Early this week, the National Institutes of Health (NIH)... read more
Cerecor Significantly Reduced Respiratory Failure and Mortality in Phase 2 Clinical Trial in Patients Hospitalized with COVID-19 ARDS
Final analysis inclusive of the 60-day safety update in the randomized placebo-controlled study demonstrated CERC-002 was statistically significant in reducing respiratory failure and mortality at Day 28 in patients hospitalized... read more
FDA Authorizes Adaptive Biotechnologies T-Detect COVID Test
U.S. Food and Drug Administration issued an emergency use authorization (EUA) for the T-Detect COVID Test developed by Adaptive Biotechnologies. The T-Detect COVID Test is a next generation sequencing based (NGS) test... read more
Resumption of Cardiac Activity after Withdrawal of Life-Sustaining Measures
After withdrawal of life-sustaining measures, transient resumption of at least one cycle of cardiac activity after pulselessness occurred in 14% of patients according to retrospective analysis of waveforms; only 1% of such... read more
Medical oxygen crisis: a belated COVID-19 response
More than a year into the pandemic, global health agencies have set up a taskforce to address the vast unmet demand for medical oxygen. The global pandemic response mechanism, the Access to COVID-19 Tools Accelerator (ACT-A),... read more
Effect of High-Dose Baclofen on Agitation-Related Events Among Patients With Unhealthy Alcohol Use Receiving Mechanical Ventilation
Among patients with unhealthy alcohol use receiving mechanical ventilation, treatment with high-dose baclofen, compared with placebo, resulted in a statistically significant reduction in agitation-related events. The primary... read more
Transfusion Strategies for Acute Upper Gastrointestinal Bleeding
As compared with a liberal transfusion strategy, a restrictive strategy significantly improved outcomes in patients with acute upper gastrointestinal bleeding. We enrolled 921 patients with severe acute upper gastrointestinal... read more
High-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure
The use of high-flow nasal oxygen upon ICU admission in adult patients with COVID-19 related acute hypoxemic respiratory failure may lead to an increase in ventilator-free days and a reduction in ICU length of stay, when... read more
Safety and Efficacy of B-Cell Depletion with Rituximab for the Treatment of SSc-PAH
B cell depletion therapy is a potentially effective and safe adjuvant treatment for systemic sclerosis-pulmonary arterial hypertension (SSc-PAH). Future studies in these patients can confirm whether the identified biomarkers... read more
Chloroquine/Hydroxychloroquine for Treating or Preventing COVID-19 Infection
When given along with azithromycin, hydroxychloroquine increased the risk of any unwanted effects, but made no difference to the risk of serious unwanted effects (1 study; 444 people). Compared with lopinavir plus ritonavir,... read more
Efficacy of Serum Angiotensin II Levels in Prognosis of Patients with COVID-19
The serum angiotensin II levels decrease significantly in patients with coronavirus disease 2019, and this decrease is correlated with lung damage. There was no statistical significance between the serum angiotensin II... read more
Antiviral Drugs in Hospitalised COVID-19 Patients
These remdesivir, hydroxychloroquine, lopinavir, and interferon regimens had little or no effect on hospitalized patients with Covid-19, as indicated by overall mortality, initiation of ventilation, and duration of hospital... read more
Single Troponin Testing in ED Patients With Suspected Acute Myocardial Infarction
One of the most common reasons for Emergency Department (ED) visits is chest pain. While most of these presentations are at a low risk for cardiac events, it is generally required to perform a full work-up to rule out an... read more
Functional outcome after inpatient rehabilitation in post-intensive care unit COVID-19 patients
These findings suggest that post-acute COVID-19 patients might beneficiate of a motor and respiratory rehabilitation treatment. However, further studies are advised to better understand long-term sequelae of the disease. Medical... read more
