The Association of Platelet Decrease Following CRRT Initiation and Increased Rates of Secondary Infections
Platelet count drop by greater than 40% following continuous renal replacement therapy (CRRT) initiation is associated with an increased risk of secondary infection, particularly in patients with thrombocytopenia at the time... read more
No Significant Difference between Tocilizumab and Placebo in Severe COVID-19 Pneumonia Patients
In this randomized trial involving hospitalized patients with severe COVID-19 pneumonia, the use of tocilizumab did not result in significantly better clinical status or lower mortality than placebo at 28 days. In this... read more
Interleukin-6 Receptor Antagonists in Critically Ill Patients with COVID-19
In critically ill patients with COVID-19 receiving organ support in ICUs, treatment with the interleukin-6 receptor antagonists tocilizumab and sarilumab improved outcomes, including survival. Both tocilizumab and sarilumab... read more
Early Hemostatic Management of Disseminated Intravascular Coagulopathy
Inflammation and coagulation pathobiology play a significant role in the development of multiorgan failure occurring with sepsis. Inflammation induced by an infection can lead to endothelial injury, which subsequently... read more
Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19
Treatment with convalescent plasma compared with placebo or standard of care was not significantly associated with a decrease in all-cause mortality or with any benefit for other clinical outcomes. The certainty of the evidence... read more
Learning From Doctors with Long COVID-19
When Sarah Burns and Sue Warren started a support group for doctors with long covid, they found a number of people struggling with new experiences, losses, and vulnerabilities Long covid has emerged as a serious, yet poorly... read more
Temporal Changes in the Epidemiology, Management, and Outcome from ARDS
The frequency of and outcome from ARDS remained relatively stable between 2002 and 2012. Plateau pressure > 29 cmH2O and driving pressure > 14 cmH2O on the first day of mechanical ventilation but not tidal volume > 8... read more
The Effect of Early Sedation With Dexmedetomidine on Body Temperature in Critically Ill Patients
Previous case series reported an association between dexmedetomidine use and hyperthermia. Temperature data have not been systematically reported in previous randomized controlled trials evaluating dexmedetomidine. Our... read more
Effect of Nurse-Led GDLPT on the Prognosis of Pneumonia in Sepsis Patients in the ICU
Nurse-led goal-directed lung physical therapy (GDLPT) improved the outcomes of pneumonia in sepsis patients, and was particularly associated with shortened mechanical ventilation duration and ICU stay, and reduced ICU mortality... read more
Management of Neonates With Tetralogy of Fallot
What are the differences in outcomes between a strategy of staged repair (SR) (initial palliation [IP] and subsequent complete repair [CR]) as compared with primary repair (PR) for infants with symptomatic tetralogy of Fallot... read more
They served on the COVID-19 front lines. Now these emergency medicine doctors can’t find jobs.
Usually, emergency medicine residents fend off recruiters hoping to hire them. This year, they’re barely getting calls back. Here's how COVID-19 has upended EM job prospects — and what these young doctors worry they may... read more
Physiological dead space and alveolar ventilation in ventilated infants
Prematurely born infants with pulmonary disease have a higher dead space than term controls, which may influence the optimum level during volume-targeted ventilation. A prospective study of mechanically ventilated infants... read more
Helmet CPAP to treat hypoxic pneumonia outside the ICU
Respiratory failure due to COVID-19 pneumonia is associated with high mortality and may overwhelm health care systems, due to the surge of patients requiring advanced respiratory support. Shortage of intensive care unit... read more
Causes and Timing of Death in Critically Ill COVID-19 Patients
Mortality rate of critically ill COVID-19 patients is high, especially in those requiring invasive mechanical ventilation. However, the causes and the timing of death of patients admitted to the ICU for SARS-CoV-2 pneumonia... read more
Analysis of Fentanyl Pharmacokinetics and Tolerance in Critically-Ill Children
Different weight-based fentanyl dosing rates may be required for infants and children of different ages to achieve similar plasma concentrations. Using SBS scores may guide the dosing titration of fentanyl that resulted in... read more
Handheld Ultrasound Device Usage and Image Acquisition Ability Among Internal Medicine Trainees
Personal handheld ultrasound devices (HUDs) without direct supervision did not increase the amount of point-of-care ultrasound (POCUS) usage or improve interns' acquisition abilities. Interns who reported performing more... read more
SOFA Score Accuracy For Determining Mortality Of Severely Ill Patients With COVID-19 Pneumonia
The SOFA score possesses inadequate discriminant accuracy to be used for ventilator triage of COVID-19 patients. A better option is needed that incorporates variables specifically related to mortality in patients with COVID-19... read more
Retrospective validation of a risk stratification tool developed for the management of patients with blunt chest trauma
The STUMBL score at a cut‐off of 15 predicted prolonged LOS and a score >18 predicted mortality sufficiently to be clinically useful for these outcomes. The STUMBL Score is composed of five simple predictors; patient... read more
Testing Asymptomatic Patients for COVID-19 – Known Unknowns
How common is asymptomatic COVID-19? How infectious is it? And how much does it actually contribute to overall transmission? Nicola Low spoke on behalf of herself and Muge Cevik to outline the role of asymptomatic transmission.... read more
Innovations in ICU Ventilation
Many centuries ago, Socrates stated that "the secret of change is to focus all of your energy, not on fighting the old, but on building the new." Nowadays, we may relate his quote with the concept of innovation, which is... read more
Epidemiology and microbiology of ventilator-associated pneumonia in COVID-19 patients
The COVID-19 pandemic is responsible for many hospitalizations in intensive care units (ICU), with widespread use of invasive mechanical ventilation (IMV) which exposes patients to the risk of ventilator-associated pneumonia... read more
Central and peripheral nervous system complications of COVID-19
CNS and PNS complications were common in hospitalized COVID-19 patients, particularly in the ICU, and often attributable to critical illness. When COVID-19 was the primary cause for neurological disease, no signs of viral... read more
