Duty of Care: One NHS Doctor’s Story of Courage and Compassion on the COVID-19 Frontline
The first book to tell the full story of the Covid-19 pandemic, from an NHS doctor working inside hospitals to save lives and combat the virus on the front line. Duty of Care is the first book to tell the full story of... read more
Effect of a Single High Dose of Vitamin D3 on Hospital LOS in Patients with COVID-19
Among hospitalized patients with COVID-19, a single high dose of vitamin D3, compared with placebo, did not significantly reduce hospital length of stay. The findings do not support the use of a high dose of vitamin D3 for... read more
The Plague Cycle: The Unending War Between Humanity and Infectious Disease
For four thousand years, the size and vitality of cities, economies, and empires were heavily determined by infection. Striking humanity in waves, the cycle of plagues set the tempo of civilizational growth and decline, since... read more
Long-Term Implications of Abnormal Left Ventricular Strain During Sepsis
Among patients with sepsis and pre-existing cardiac disease who survived to ICU discharge, left ventricular global longitudinal systolic strain demonstrated a U-shaped association with cardiovascular outcomes through 24 months.... read more
Early Intervention for the Treatment of Acute Laryngeal Injury After Intubation
This study suggests that early intervention for patients with postintubation laryngeal injury was associated with a decreased duration of tracheostomy dependence, a higher rate of decannulation, and fewer surgical procedures... read more
Insight into ECMO, mortality and ARDS
ARDS is a severe disease with a high mortality rate despite ECLS therapy. Although endpoints and timing of the evaluations differed from those of the CESAR and EOLIA studies and the Extracorporeal Life Support Organization... read more
Haloperidol, Clonidine and Resolution of Delirium in Critically Ill Patients
Haloperidol and clonidine use in delirious ICU patients may be associated with reduced probability of delirium resolution. This finding, however, merits further investigation given inherent limitations of this observational... read more
The Rules of Contagion: Why Things Spread – And Why They Stop
From ideas and infections to financial crises and fake news, an "utterly timely" look at why the science of outbreaks is the science of modern life These days, whenever anything spreads, whether it's a YouTube fad or a... read more
Study finds genetic clues to pneumonia risk and COVID-19 disparities
Researchers at Vanderbilt University Medical Center and colleagues have identified genetic factors that increase the risk for developing pneumonia and its severe, life-threatening consequences. Their findings, published... read more
Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection
The current pandemic originated by SARS-CoV-2 causes an unprecedented health crisis. The medical world has found itself helpless in the face of this virus, having to deal with the absence of specific effective treatment.... read more
Is chloroquine or hydroxychloroquine useful in treating people with COVID-19, or in preventing infection in people who have been exposed to the virus?
COVID-19 is an infectious respiratory disease caused by a coronavirus called SARS-CoV-2. If the infection becomes severe, people may need intensive care and support in hospital, including mechanical ventilation. Drugs... read more
Barotrauma in Mechanically-ventilated Patients with COVID-2019
Within the limits of a survey, patients with COVID-19 might be at high risk for barotrauma during invasive (and allegedly lung-protective) mechanical ventilation. The response rate was 38/61 (62%). The incidence of... read more
Temporal development and neutralising potential of antibodies against SARS-CoV-2 in hospitalised COVID-19 patients
Antibody responses are important in the control of viral respiratory infection in the human host. What is not clear for SARS-CoV-2 is how rapidly this response occurs, or when antibodies with protective capability evolve.... read more
RECOVERY trial shows tocilizumab reduces deaths in patients hospitalised with COVID-19
The NIHR-supported RECOVERY trial has shown that tocilizumab - an anti-inflammatory rheumatoid arthritis treatment - reduces the risk of death for hospitalised patients with severe COVID-19. Researchers also found that... read more
Surviving Sepsis Campaign Guidelines on the Management of Adults with COVID-19 in the ICU
The Surviving Sepsis Campaign Coronavirus Disease 2019 panel issued several recommendations to guide healthcare professionals caring for adults with critical or severe coronavirus disease 2019 in the ICU. Based on a living... read more
Safety of RSI in an Emergency Training Network
Implementation of an evidence-based care bundle and audit of practice has created a safe environment for trainees to learn the core critical care skill of Rapid sequence intubation (RSI). In our setting, checklist use was... read more
An Index Combining Respiratory Rate and Oxygenation to Predict Outcome of Nasal High-Flow Therapy
In patients with pneumonia with acute respiratory failure treated with high-flow nasal cannula (HFNC), ROX is an index that can help identify those patients with low and those with high risk for intubation. This was a... read more
Resident competencies before and after short ICU rotations
A monthly multi-competency assessment for specialty residents rotating in the ICU is likely feasible for most programs with appropriate resources, and generally acceptable for residents. Specialty residents' cognitive reasoning... read more
COVID-19 and VILI: Mechanical Power Measurement
The COVID-19 pandemic has increased the need for a bedside tool for lung mechanics assessment and ventilator-induced lung injury (VILI) monitoring. Mechanical power is a unifying concept including all the components which... read more
COVID-19 Awake Proning – All Hype?
In this prospective meta-analysis of observational studies of patients with acute hypoxemic respiratory failure due to COVID-19, APP did not result in lower intubation or mortality rates, despite reported improvements in... read more
Mediastinal lymphadenopathy may predict 30-day mortality in COVID-19 patients
Along with older age and consolidation pattern,enlarged mediastinal lymphadenopathy was found to be an independent predictor of 30-day mortality in patients with COVID-19. Although enlarged mediastinal lymphadenopathy... read more
Rapid detection of clinically-relevant plasma direct oral anticoagulant levels following acute traumatic injury
In urgent clinical situations, such as trauma, urgent surgery or before thrombolysis, rapid quantification of direct oral anticoagulant plasma drug levels is warranted. Using the ClotPro® analyser, we assessed two novel... read more
