Clinical Outcomes of Early Phenotype-Desirable Antimicrobial Therapy for Enterobacterales Bacteremia

This is first study to compare clinical outcomes between patients with E coli, K pneumoniae, K oxytoca, and P mirabilis BSIs receiving early PDAT vs delayed PDAT using DOOR analysis. Receiving early phenotype-desirable... read more

Prediction of AKI in ICU Patients Based on Interpretable Machine Learning

The machine learning model described in this study is capable of accurately predicting the onset of AKI in ICU patients up to 24 hours in advance. Validated within the MIMIC-IV and MIMIC-III databases, the model demonstrates... read more

Textbook of Cardiorenal Medicine

This textbook provides a practical and board-driven resource to describe and define the emerging field of cardiorenal medicine. Covering all aspects of the topic with depth and relevance, this groundbreaking reference brings... read more

Textbook of Cardiorenal Medicine

Fluid Bolus Therapy with 20% Albumin vs. Crystalloid-based Regimen

In this trial involving adult patients undergoing cardiac surgery with cardiopulmonary bypass, 20% albumin fluid bolus therapy (FBT) compared to crystalloid FBT did not decrease the occurrence of acute kidney injury (AKI).... read more

New Insights on CRRT for ARDS

In recent times, the applications of continuous renal replacement therapy (CRRT) beyond kidney‐related conditions have been progressively increasing, and its implementation in randomized controlled trials (RCTs) specifically... read more

Increased Lactate Dehydrogenase to Albumin Ratio Associated with Short-term Mortality in Septic ICU Patients

Elevated lactate dehydrogenase to albumin ratio (LAR) was found to be significantly associated with an increased risk of all-cause mortality at 28 and 90 days in septic patients. LAR was suggested to be promising biomarker... read more

Rethinking Energy and Protein Provision for Critically Ill Patients

In critically ill patients, we suggest that energy and protein be delivered progressively in stable or recovering patients. If a patient deteriorates, regardless of days spent in the ICU, low-dose energy and protein should... read more

Clinical Companion in Nephrology

The second edition of this educational book provides an updated resource on how best to discuss and manage acute and chronic presentations of renal diseases. All chapters have been reviewed and updated to reflect changes... read more

Clinical Companion in Nephrology

Critical Care Pediatric Nephrology and Dialysis

This book covers all key aspects of critical care in pediatric nephrology, including acute dialysis in sick children. It also provides detailed protocols for managing fluid and electrolyte balance and dialysis in children... read more

Critical Care Pediatric Nephrology and Dialysis

Protocolized Fluid Balance Neutralization During CRRT

Bitker et al. report the GO NEUTRAL randomized clinical trial results, which investigated fluid balance neutralization guided by functional hemodynamic monitoring (FHM) protocol versus a standard of care in critically ill... read more

Adjusting risk of AKI for Time on Controlled Mechanical Ventilation in ARDS

The authors expressed concerns that the study did not account for certain key covariates, such as septic shock, right heart failure, or hypoxemia, which are believed to influence the development of AKI. We would like... read more

Plasma Bioactive Adrenomedullin Predicts Mortality and Need for Dialysis in Critical COVID-19

In this study, serial bio-ADM samples in the ICU had limited predictive power for mortality in critically ill COVID-19 patients when looking at absolute values. Still, relative changes over time showed a much better prediction.... read more

Early sodium bicarbonate therapy for critically ill patients with septic shock and acute moderate metabolic acidosis

In recent decades, septic shock has continued to be a life-threatening health problem around the world. Meanwhile, metabolic acidosis (MA) is also well known in critically ill patients, and even moderate metabolic acidosis... read more

Critical Care Nephrology and Renal Replacement Therapy in Children

Pediatric critical care nephrology is a complex and highly specialized field, presenting challenges and management strategies that are often quite distinct from those seen in adult practice. Therefore, it is high time... read more

Critical Care Nephrology and Renal Replacement Therapy in Children

Core Concepts in Acute Kidney Injury

This comprehensive guide covers the causes, characteristics, and presentations of acute kidney injury (AKI), as well as prevention and treatment. The first part of the book features chapters on the epidemiology and diagnosis... read more

Core Concepts in Acute Kidney Injury

Endothelial Activation and Microcirculatory Disorders in Sepsis and Critical Illness

The endothelium is one of the largest organs in the human body and lines the blood vessels and microcirculation of all the vital organs. As such, it functions as a massive and critical surveillance system to orchestrate recognition... read more

AI to Predicting Mortality Risk in ICU Patients with AKI

To address the limitations of early acute kidney injury (AKI) prediction, researchers have increasingly turned to machine learning methods. However, the success of these models hinges on the selection of relevant features.... read more