Tag: AKI
The Kidney Crisis: Acute Injury as a Predictor of ICU Survival
This extensive population-level study from Ontario, Canada, analyzed over 480,000 adult ICU admissions to clarify the relationship between Acute Kidney Injury (AKI) and patient outcomes. By utilizing outpatient baseline data... read more
Predicting Sepsis-associated Encephalopathy in Septic ICU Patients with AKI
Researchers developed a simple, interpretable nomogram to predict sepsis-associated encephalopathy (SAE) on day 1 in septic ICU patients who also have acute kidney injury (AKI), using data from the large MIMIC-IV database... read more
Integration Equals Separation for CRRT Filter Lifespan in ECMO Patients (E-CRRT Trial)
The multicenter randomized controlled E-CRRT Trial, conducted from May 2021 to March 2025 at King Chulalongkorn Memorial Hospital (KCMH) and Central Chest Institute of Thailand (CCIT), compared two strategies for combining... read more
The Dangerous Duo: How Delirium Compounds Risks in Acute Kidney Injury
This systematic review and meta-analysis of over 158,000 critically ill patients reveals a significant link between Acute Kidney Injury (AKI) and delirium, affecting approximately 32% of patients with AKI. The study found... read more
Blood Pressure Disorders in Acute and Chronic Kidney Diseases (Updates in Hypertension and Cardiovascular Protection)
This new book is intended to be an in-depth and up-to-date guide to the various aspects of the association between blood pressure disorders and acute/chronic renal diseases. In addition, this work includes discussion... read more
Nutrition in ICU Patients
This book discusses practical topics in critical care nutrition including basic principles and practices in nutrition support in the ICU. Tailoring nutrition solutions is crucial for the development and prognosis of critical... read more
TXA in Cardiac Surgery: No Harm to Kidneys, Shorter Stays!
A systematic review and meta-analysis of 19 randomized controlled trials, encompassing 6,807 patients undergoing cardiovascular surgery, investigated the effect of tranexamic acid (TXA) administration on renal outcomes. The... read more
Post-Hospital AKI: A Long-Term Health Hazard
A systematic review and meta-analysis of 14 matched control studies, totaling over 1 million patients, investigated the long-term outcomes following an episode of Acute Kidney Injury (AKI) during hospitalization. The... read more
BICARICU-2: Bicarb Infusions Curb Dialysis Needs in Acidotic AKI
The BICARICU-2 trial investigated the use of sodium bicarbonate (NaHCO3) infusions for critically ill patients suffering from severe acidemia and Acute Kidney Injury (AKI), most often due to septic shock. While the trial,... read more
The Falling Count: Platelet Trajectory Post-CRRT Predicts Mortality in AKI
This retrospective cohort study examined the dynamic changes in platelet counts—the platelet trajectory—around the initiation of Continuous Renal Replacement Therapy (CRRT) in over 2,200 critically ill adults with Acute... read more
Salinity Signal: Low Sodium-Chloride Difference Predicts Higher Mortality in Critically Ill Adults
This retrospective cohort study investigated the relationship between the easily calculated Sodium–Chloride Difference (SCD) at the time of ICU admission and the patient's subsequent 30-day mortality risk in 1,726 critically... read more
Vasoactive Guard: Testing Arginine-Vasopressin to Shield Kidneys Post-Liver Transplant
This clinical trial investigates whether a low dose of argipressin (the active substance in REVERPLEG) administered during liver transplantation surgery can help prevent Acute Kidney Injury (AKI), a severe and common post-operative... read more
SOFA-2: Close, But Not Quite the Ideal Measure of Organ Failure
The SOFA-2 (Sequential Organ Failure Assessment) score represents the latest effort to provide a simple, reliable, and continuous measure of organ dysfunction in critically ill patients, a concept first outlined decades ago.... read more
AI Reinforcement Learning Slashes Kidney Injury Risk After Surgery
This study explored the use of Reinforcement Learning (RL)-a type of artificial intelligence—to personalize hemodynamic management (managing blood flow and pressure) in the intensive care unit (ICU) immediately following... read more
Machine Learning Can Effectively Identify Septic Patients with AKI
Causal Machine Learning (ML) framework outperformed random forest model in identifying patients with AKI and sepsis who benefit from restrictive fluid therapy. This provides a data-driven approach for personalized fluid management... read more
Low Phosphate Linked to Extended Hospitalization in Neonatal Sepsis
This retrospective cohort study investigated the relationship between serum phosphate levels and outcomes in neonates with sepsis using data from the Pediatric Intensive Care (PIC) database. Lower serum phosphate levels... read more
Precision Hydration: Causal Machine Learning Pinpoints Sepsis-AKI Patients Who Thrive on Less IV Fluid
The results of this study demonstrate that a causal machine learning (ML) framework can successfully identify patients with sepsis-AKI who benefit from a restrictive fluid strategy. This technology offers a promising, data-driven... read more
The Double Danger: Electrolyte Chaos in AKI Drives Worse Outcomes
Electrolyte imbalances and metabolic acidosis are highly prevalent complications in Acute Kidney Injury (AKI) and are directly linked to adverse patient outcomes, including death and a greater need for intensive care. The... read more
Workbook on Renal Replacement Therapy in ICU (ISCCM)
This workbook focuses on renal replacement therapy in ICU. The incidence of acute kidney injury in critically ill patients is increasing steeply. Acute kidney injury in this setting is associated with high morbidity and mortality.... read more
Medication Management: Spontaneous vs. Traumatic Intracerebral Hemorrhage (sICH vs. tICH)
Pharmacological management for BP control and seizure prophylaxis differs between tICH and sICH. ICH etiology should be accounted for in determining appropriate BP goals and the necessity of seizure prophylaxis. Intracerebral... read more
Unmasking the Burden: High IAH Prevalence, Associated Morbidity, and Novel Mortality Predictors in Critical Care
This study on 85 critically ill patients revealed a high prevalence of Intra-Abdominal Hypertension (IAH) (54.1%). Key Findings: Primary Contributors: The main factors driving IAH were intravenous (IV) fluid administration... read more
Beyond Creatinine: A Systematic Review of Biomarker Performance (NGAL, KIM-1, TIMP-2·IGFBP7) for Acute Kidney Injury in the ICU
This systematic review analyzed 35 studies to assess the performance of three key Acute Kidney Injury (AKI) biomarkers—NGAL, KIM-1, and TIMP-2 ⋅ IGFBP7—in the Intensive Care Unit (ICU) setting. NGAL (Neutrophil Gelatinase-Associated... read more
