Higher Protein Dosing in Critically Ill Patients with High Nutritional Risk

Higher Protein Dosing in Critically Ill Patients with High Nutritional Risk

Delivery of higher doses of protein to mechanically ventilated critically ill patients did not improve the time-to-discharge-alive from hospital and might have worsened outcomes for patients with acute kidney injury (AKI)... read more

Bayesian Reanalysis of the Standard vs. Accelerated Initiation of RRT in AKI Trial

Bayesian Reanalysis of the Standard vs. Accelerated Initiation of RRT in AKI Trial

Timing of initiation of kidney-replacement therapy (KRT) in critically ill patients remains controversial. The Standard versus Accelerated Initiation of Renal-Replacement Therapy (RRT) in Acute Kidney Injury (STARRT-AKI)... read more

Acid-Base Disorders in the Critically III Patient

Acid-Base Disorders in the Critically III Patient

Acid-base disorders are common in the intensive care unit. By utilizing a systematic approach to their diagnosis, it is easy to identify both simple and mixed disturbances. These disorders are divided into four major categories:... read more

Association of Vancomycin Plus Piperacillin-tazobactam with Early Changes in Creatinine vs. Cystatin C

Association of Vancomycin Plus Piperacillin-tazobactam with Early Changes in Creatinine vs. Cystatin C

Although dozens of studies have associated vancomycin + piperacillin–tazobactam with increased acute kidney injury (AKI) risk, it is unclear whether the association represents true injury or a pseudotoxicity characterized... read more

Subphenotypes of AKI in Adults

Subphenotypes of AKI in Adults

Subphenotyping may help reduce heterogeneity under the umbrella term of acute kidney injury (AKI). Despite challenges remain, the identification of AKI subphenotypes has opened the potential of AKI research focused on better... read more

Is Continuous Intra-abdominal Pressure Ready For Prime Time?

Is Continuous Intra-abdominal Pressure Ready For Prime Time?

Abdominal contents are primarily fluid in character so that pressure within this compartment follows Pascal's hydrostatic law. Intra-abdominal pressure (IAP) is the steady state pressure within the abdominal cavity and changes... read more

Sepsis-Associated AKI Risks in the PICU

Sepsis-Associated AKI Risks in the PICU

In children with severe sepsis, the degree of hemodynamic support as measured by the VIS and the presence of fluid overload may identify patients at increased risk of developing severe acute kidney injury (AKI). Children... read more

Optimizing the Design and Analysis of Future AKI Trials

Optimizing the Design and Analysis of Future AKI Trials

Acute kidney injury (AKI) is a complex clinical syndrome associated with an increased risk of morbidity and mortality, particularly in critically ill and perioperative patient populations. Most AKI clinical trials have... read more

Acute Kidney Injury Related to Intoxication From Synthetic Cannabis

Acute Kidney Injury Related to Intoxication From Synthetic Cannabis

Acute kidney injury (AKI) occurs infrequently in young patients and often raises concern for irreversible or deadly etiologies. However, AKI related to synthetic marijuana, colloquially known as K2, is an increasingly common... read more

Reducing Mortality in Acute Kidney Injury

Reducing Mortality in Acute Kidney Injury

This book describes the techniques, strategies, and drugs that have been demonstrated by at least one paper published in a peer-reviewed journal to significantly influence survival in patients with or at risk for acute kidney... read more

Multi-Organ Point-Of-Care Ultrasound in AKI

Multi-Organ Point-Of-Care Ultrasound in AKI

Acute kidney injury (AKI) is a clinical syndrome caused by a multitude of hemodynamic, toxic, and structural insults to the kidney, and portends worse patient outcomes. Despite careful history taking, physical examination,... read more

Balanced Crystalloids Probably Reduce Mortality in the Critically-Ill

Balanced Crystalloids Probably Reduce Mortality in the Critically-Ill

As remarked by the authors of the recent PLUS trial, a systematic review and meta-analysis of randomized controlled trials comparing balanced resuscitation fluid to 0.9% saline was reported in the New England Journal of Medicine... read more

Balanced vs. Unbalanced Fluid in Critically Ill Children

Balanced vs. Unbalanced Fluid in Critically Ill Children

Our systematic review found some evidence of improvement in blood pH and bicarbonate values in critically ill children after 4–12 hours of fluid bolus therapy with balanced fluid compared with the unbalanced fluid. However,... read more

Balanced Fluid Resuscitation for the Critically-Ill: the PLUS study mirrors the BaSICS

Balanced Fluid Resuscitation for the Critically-Ill: the PLUS study mirrors the BaSICS

Intravenous fluid therapy is one of the most commonly-performed interventions in all of critical care medicine. Numerous trials over the last 20 years have attempted to identify the ideal fluid for those in the intensive... read more