Biomarkers for Prediction of RRT in AKI

Biomarkers for Prediction of RRT in AKI

Acute kidney injury (AKI) frequently occurs in critically ill patients and often precipitates use of renal replacement therapy (RRT). However, the ideal circumstances for whether and when to start RRT remain unclear. We performed... read more

Outcomes in Patients with Vasodilatory Shock and RRT Treated with Intravenous Angiotensin II

Outcomes in Patients with Vasodilatory Shock and RRT Treated with Intravenous Angiotensin II

Acute kidney injury (AKI) requiring renal replacement therapy in severe vasodilatory shock is associated with an unfavorable prognosis. Angiotensin II treatment may help these patients by potentially restoring renal function... read more

Predictors, Prevalence, and Outcomes of Early Crystalloid Responsiveness Among Initially Hypotensive Patients With Sepsis and Septic Shock

Predictors, Prevalence, and Outcomes of Early Crystalloid Responsiveness Among Initially Hypotensive Patients With Sepsis and Septic Shock

Two in three hypotensive sepsis patients were responsive to initial fluid resuscitation. Heart failure, hypothermia, immunocompromise, hyperlactemia, and coagulopathy were associated with the refractory phenotype. Fluid resuscitation... read more

The Effect of 6% Hydroxyethyl Starch (130/0.4) On AKI in Pediatric Cardiac Surgery

The Effect of 6% Hydroxyethyl Starch (130/0.4) On AKI in Pediatric Cardiac Surgery

We have evaluated the effect of a colloid solution on acute kidney injury in paediatric cardiac surgery. A total of 195 patients were randomly divided into an hydroxyethyl starch group and a control group. In the starch group,... read more

Risk Factors for Ventilator-Associated Events in a PICU

Risk Factors for Ventilator-Associated Events in a PICU

There is an association between ventilator-associated condition and infection-related ventilator-associated complication in critically ill children with acute kidney injury, ventilatory support, and neuromuscular blockade.... read more

Dexmedetomidine Prevents AKI After Adult Cardiac Surgery

Dexmedetomidine Prevents AKI After Adult Cardiac Surgery

Perioperative administration of dexmedetomidine in adult patients undergoing cardiac surgery may reduce the incidence of postoperative AKI. Future trials are needed to determine the dose and timing of dexmedetomidine in improving... read more

Acute Kidney Injury in Sepsis

Acute Kidney Injury in Sepsis

Acute kidney injury (AKI) and sepsis carry consensus definitions. The simultaneous presence of both identifies septic AKI. Septic AKI is the most common AKI syndrome in ICU and accounts for approximately half of all such... read more

Urinary Oxygenation as a Surrogate Measure of Medullary Oxygenation During Angiotensin II Therapy in Septic AKI

Urinary Oxygenation as a Surrogate Measure of Medullary Oxygenation During Angiotensin II Therapy in Septic AKI

In septic acute kidney injury (AKI), renal medullary and urinary hypoxia developed several hours before increases in currently used biomarkers. Angiotensin II transiently improved renal function without worsening medullary... read more

Harrison’s Nephrology and Acid-Base Disorders

Harrison’s Nephrology and Acid-Base Disorders

Featuring a superb compilation of chapters related to nephrology and acid-base disorders derived from Harrison's Principles of Internal Medicine, Nineteenth Edition, this concise, full-color clinical companion delivers the... read more

Renal Recovery – RRT Modality

Renal Recovery – RRT Modality

Renal recovery - does the choice of renal replacement therapy matter?... read more

Risk of Venous Thromboembolism in Patients by Albuminuria and Estimated GFR

Risk of Venous Thromboembolism in Patients by Albuminuria and Estimated GFR

Albuminuria increases the risk for VTE markedly in patients with normal eGFRs compared with those with lower eGFRs. 15,180 (2.2%) VTE events occurred during the study period. Both albuminuria and eGFR were independently associated... read more

Intra-Abdominal Hypertension and Abdominal Compartment Syndrome

Intra-Abdominal Hypertension and Abdominal Compartment Syndrome

Intra-abdominal hypertension (IAH) and abdominal compartment syndrome are increasingly recognized in both medical and surgical critically ill patients and are predictive of death and the development of acute kidney injury.... read more

The 10 False Beliefs in Adult Critical Care Nephrology

The 10 False Beliefs in Adult Critical Care Nephrology

Acute tubular necrosis (ATN), a histological pattern observed after ischemic insult, is considered the most frequent cause of any form of acute kidney injury (AKI) despite the absence of extensive histological data. This... read more

Kinetic Estimated Glomerular Filtration Rate in Critically Ill Patients

Kinetic Estimated Glomerular Filtration Rate in Critically Ill Patients

Both the Acute kidney injury (AKI) classification system and the nonsteady-state (kinetic) estimated glomerular filtration rate (KeGFR) are complementary to each other. Assessing both AKI stage and KeGFR can help to identify... read more

Better AKI Patient Survival Linked to Negative Fluid Balance

Better AKI Patient Survival Linked to Negative Fluid Balance

Optimal fluid management of critically ill patients with or at risk for acute kidney injury (AKI) is still uncertain. Now a new prospective study from India confirms that patients with negative fluid balance live longer.... read more

Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine

Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine

Intravenous sodium bicarbonate and oral acetylcysteine are widely used to prevent acute kidney injury (AKI) and associated adverse outcomes after angiography without definitive evidence of their efficacy. Among patients at... read more

Is Intravenous Administration of Iodixanol Associated with Increased Risk of AKI, Dialysis, or Mortality?

Is Intravenous Administration of Iodixanol Associated with Increased Risk of AKI, Dialysis, or Mortality?

Among patients at the highest perceived risk of post-contrast Acute Kidney Injury (AKI), intravenous administration of iodixanol for contrast material enhanced CT was not an independent risk factor for AKI, dialysis, or... read more