Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest

Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest

Among patients with in-hospital cardiac arrest, administration of vasopressin and methylprednisolone, compared with placebo, significantly increased the likelihood of return of spontaneous circulation. However, there is uncertainty... read more

Neurological Complications Acquired During Pediatric Critical Illness

Neurological Complications Acquired During Pediatric Critical Illness

Graphical models that include biomarkers in addition to clinical data are promising methods to evaluate direct relationships in the development of neurologic complications in critically ill children. Future work is required... read more

Impact of Marijuana on Venous Thromboembolic Events

Impact of Marijuana on Venous Thromboembolic Events

Tetrahydrocannabinoids (THC) exposure increases the risk of TEC in patients with trauma. Early identification and treatment for TEC is required to improve outcomes in this high-risk subset of trauma patients. We performed... read more

COVID-19 Antibody Seropositivity Longevity Analysis

COVID-19 Antibody Seropositivity Longevity Analysis

Seropositivity of IgG antibodies to both SARS-CoV-2 S and N-proteins followed a linear trend reaching approximately 90% positivity at 21 days post-index. The rate of N-protein seropositivity declined at a sharper rate,... read more

Ultrasound Grayscale Analysis in ARDS COVID-19

Ultrasound Grayscale Analysis in ARDS COVID-19

Recent evidence regarding the novel coronavirus disease 2019 (COVID19) is growing in describing the characteristics of this disease, with main focus on lung morphology. Few data are available regarding the peripheral and... read more

Intraosseous vs. Intravenous Vascular Access During CPR for Out-of-hospital Cardiac Arrest

Intraosseous vs. Intravenous Vascular Access During CPR for Out-of-hospital Cardiac Arrest

The meta-analysis revealed no significant association between types of vascular access and neurological outcomes at hospital discharge among out-of-hospital Cardiac Arrest (OHCA) patients. Time to intervention was identified... read more

Safety and Efficacy of B-Cell Depletion with Rituximab for the Treatment of SSc-PAH

Safety and Efficacy of B-Cell Depletion with Rituximab for the Treatment of SSc-PAH

B cell depletion therapy is a potentially effective and safe adjuvant treatment for systemic sclerosis-pulmonary arterial hypertension (SSc-PAH). Future studies in these patients can confirm whether the identified biomarkers... read more

The fragility index in randomised controlled trials of interventions for aneurysmal subarachnoid hemorrhage

The fragility index in randomised controlled trials of interventions for aneurysmal subarachnoid hemorrhage

Fragility analysis supplements the p-value and risk of bias assessment in the interpretation of results of randomised controlled trials. In this systematic review we determine the fragility index (FI) and fragility quotient... read more

De Novo Renal Failure and Clinical Outcomes of Patients With Critical COVID-19

De Novo Renal Failure and Clinical Outcomes of Patients With Critical COVID-19

This case series concludes that respiratory failure conveys significant mortality risk in patients with coronavirus disease 2019 and that survival with concomitant renal failure is rare. This is a case series of patients... read more

COVID-19 Blood Plasma Trial Finds No Benefit in Severely Ill Patients

COVID-19 Blood Plasma Trial Finds No Benefit in Severely Ill Patients

An international trial testing convalescent blood plasma on COVID-19 patients with moderate and severe illness has halted enrolment of severely ill COVID-19 patients requiring intensive care after it found no benefit. The... read more

Estimate Artery Occlusion Pressure in Critically Ill Patients Under Mechanical Ventilation Using Doppler Echocardiography

Estimate Artery Occlusion Pressure in Critically Ill Patients Under Mechanical Ventilation Using Doppler Echocardiography

In mechanically ventilated critically ill patients, Doppler transthoracic echocardiography indices are highly specific but not sensitive to estimate pulmonary artery occlusion pressure. Transmitral early velocity wave... read more

Harmonizing Heterogeneous Endpoints in COVID-19 Trials Without Loss of Information

Harmonizing Heterogeneous Endpoints in COVID-19 Trials Without Loss of Information

All ongoing clinical trials should include a stacked probability plot in their statistical analysis plan as descriptive analysis. While primary analysis should be on an early endpoint with appropriate capability to be... read more

Modifiable Factors Associated With Chronic Pain After Surgery for Distal Radius Fractures

Modifiable Factors Associated With Chronic Pain After Surgery for Distal Radius Fractures

In this study, preoperative pain, time to surgery, and procedure type were modifiable factors associated with chronic pain 1 year after DRF treated with surgery. Adequate pain control in patients with acute DRFs even... read more

Evidence-Based Critical Care

Evidence-Based Critical Care

This is the premier evidence-based textbook in critical care medicine. The Third Edition features updated and revised chapters, numerous new references, streamlined content, and new chapters on key topics such as the new... read more