Antipsychotic Drugs are Not Useful to Reduce Symptoms of Delirium

Antipsychotic Drugs are Not Useful to Reduce Symptoms of Delirium

In patients receiving palliative care, individualized management of delirium precipitants and supportive strategies result in lower scores and shorter duration of target distressing delirium symptoms than when risperidone... read more

Epinephrine, Inodilator, or No Inotrope in VA-ECMO Implantation

Epinephrine, Inodilator, or No Inotrope in VA-ECMO Implantation

Early epinephrine therapy within the first 24 h after cannulation for venoarterial extracorporeal membrane oxygenation (VA-ECMO) was associated with poor survival compared to patients with or without any inodilator therapy.... read more

The Speaker Gender Gap at Critical Care Conferences

The Speaker Gender Gap at Critical Care Conferences

There is a speaker gender gap at critical care conferences, with male faculty outnumbering female faculty. This gap is more marked among physician speakers than those speakers representing nursing and allied health professionals.... read more

Ramelteon for Prevention of Postoperative Delirium

Ramelteon for Prevention of Postoperative Delirium

Ramelteon 8 mg did not prevent postoperative delirium in patients admitted for elective cardiac surgery. Incident delirium was measured twice daily using the Confusion Assessment Method-ICU. The safety outcome was... read more

Traditional vs. Alternative Metrics to Measure the Impact on Critical Care Medicine

Traditional vs. Alternative Metrics to Measure the Impact on Critical Care Medicine

In this analysis of major pulmonary and critical care journals the correlation between traditional publishing metrics and Altmetric Attention Scores (AAS) was fair, with a strong positive correlation between citations and... read more

Critically Ill Patients Show a Differential Contractile Response to Neuromuscular Electrical Stimulation

Critically Ill Patients Show a Differential Contractile Response to Neuromuscular Electrical Stimulation

This retrospective sub-analysis aimed to outline the characteristics of, as well as predictors for, a contractile response to Neuromuscular Electrical Stimulation (NMES), and also potential clinical benefits resulting from... read more

Mechanical Ventilation Management during ECMO for ARDS

Mechanical Ventilation Management during ECMO for ARDS

Ultra-protective lung ventilation on ECMO was largely adopted across medium to high case-volume ECMO centers. In contrast with previous observations, mechanical ventilation settings during ECMO did not impact patients' prognosis... read more

Association Between Mean Arterial Pressure and AKI and a Composite of Myocardial Injury and Mortality in Postoperative Critically Ill Patients

Association Between Mean Arterial Pressure and AKI and a Composite of Myocardial Injury and Mortality in Postoperative Critically Ill Patients

Hypotension thresholds that provoke renal injury, myocardial injury, and mortality in critical care patients remain unknown. We primarily sought to determine the relationship between hypotension and a composite of myocardial... read more

Implications of Heterogeneity of Treatment Effect for Reporting and Analysis of Randomized Trials in Critical Care

Implications of Heterogeneity of Treatment Effect for Reporting and Analysis of Randomized Trials in Critical Care

Randomized clinical trials (RCTs) are conducted to guide clinicians' selection of therapies for individual patients. Currently, RCTs in critical care often report an overall mean effect and selected individual subgroups.... read more

More Precise Sepsis Therapy with Distinct Clinical Phenotypes

More Precise Sepsis Therapy with Distinct Clinical Phenotypes

In this retrospective analysis of data sets from patients with sepsis, 4 clinical phenotypes were identified that correlated with host-response patterns and clinical outcomes, and simulations suggested these phenotypes may... read more

Randomized Controlled Trial of Health Coaching for Vulnerable Patients with COPD

Randomized Controlled Trial of Health Coaching for Vulnerable Patients with COPD

These results help inform expectations regarding the limitations and benefits of health coaching for patients with Chronic Obstructive Pulmonary Disease (COPD). They may be useful to health policy experts in assessing the... read more

Prevalence and outcome of heparin-induced thrombocytopenia diagnosed under veno-arterial extracorporeal membrane oxygenation

Prevalence and outcome of heparin-induced thrombocytopenia diagnosed under veno-arterial extracorporeal membrane oxygenation

Prevalence of HIT among patients under VA‑ECMO is extremely low at 0.36% with an associated mortality rate of 33.3%, which appears to be in the same range as that observed in patients treated with VA‑ECMO without HIT.... read more

Using Propensity Scoring Analyses in Critical Care Research

Using Propensity Scoring Analyses in Critical Care Research

Observational studies are a common and important aspect of critical care research. A key challenge in the design of observational studies is the control of confounding. Confounding arises when the groups being compared in... read more

Impact of Mean Arterial Pressure Fluctuation on Mortality in Critically Ill Patients

Impact of Mean Arterial Pressure Fluctuation on Mortality in Critically Ill Patients

The purpose of this study was to investigate the association between mean arterial pressure fluctuations and mortality in critically ill patients admitted to the ICU. The reduced mean arterial pressure fluctuation (within... read more