Cytokine Storm Syndrome

Cytokine Storm Syndrome

Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of... read more

COVID-19 Airway Management and Ventilation Strategy for Critically Ill Older Patients

COVID-19 Airway Management and Ventilation Strategy for Critically Ill Older Patients

This book describes the issues and challenges that clinicians encountered in the management of older critically ill patients during the COVID-19 pandemic, and offers practical information on how to manage them. Older... read more

Uncommon Diseases in the ICU

Uncommon Diseases in the ICU

This book highlights the practical characteristics of uncommon diseases and presents the most relevant features for the management of intensive care units. It does not aim to provide an exhaustive description of uncommon... read more

Evolving Crisis Standards of Care and Ongoing Lessons from COVID-19

Evolving Crisis Standards of Care and Ongoing Lessons from COVID-19

Crisis Standards of Care (CSC) inform decisions on medical care during a large-scale crisis such as a pandemic or natural disaster, eliminating the need to make these decisions at the bedside without protections or guidance.... read more

Acquired Weakness and Hospital Functional Mobility Outcomes Following Invasive Mechanical Ventilation in Patients with COVID-19

Acquired Weakness and Hospital Functional Mobility Outcomes Following Invasive Mechanical Ventilation in Patients with COVID-19

In critically ill COVID-19 patients, the incidence of ICUAW and acute gait dependence were high. Our study identifies factors influencing both outcomes. Future studies should investigate optimal COVID-19 ARDS management and... read more

Disposable Hospital Gowns May Pose Infection Risk

Disposable Hospital Gowns May Pose Infection Risk

Disposable gowns designed to deflect the splatter of bodily fluids, used in thousands of U.S. hospitals, have underperformed in recent and ongoing laboratory tests and may fall short of safety standards, leaving health care... read more

The Mysterious Vanishing of MIS-C

The Mysterious Vanishing of MIS-C

Whilst the overwhelming majority of Covid-19 infections in healthy children are mild or asymptomatic, the serious risk which remained was of the hyperinflammatory syndrome known as MIS-C (Multi-system Inflammatory Syndrome... read more

Pericarditis and Myocarditis in the ED

Pericarditis and Myocarditis in the ED

Chest pain is one of the most common presentations to the emergency department (ED) and includes a wide differential diagnosis. In today’s post, we will review a less common cause of chest pain seen in the ED: pericarditis... read more

Hydroxychloroquine Not Associated With Decreased Risk for COVID-19 Hospitalization

Hydroxychloroquine Not Associated With Decreased Risk for COVID-19 Hospitalization

Results of a multicenter, double-blinded, randomized controlled trial found no evidence to support the use of hydroxychloroquine for COVID-19 infection in the outpatient setting. These findings were published in The Lancet... read more

Majority of Family Members of COVID-19 Patients Treated in the ICU Report PTSD Symptoms

Majority of Family Members of COVID-19 Patients Treated in the ICU Report PTSD Symptoms

A majority of family members of COVID-19 patients treated in ICUs reported significant symptoms of post-traumatic stress disorder in the following months, according to a study published Monday that sheds new light on the... read more

Inflammation Causes COVID-19-related Loss of Smell Not The Virus

Inflammation Causes COVID-19-related Loss of Smell Not The Virus

This study found that COVID-19 infection is associated with axon injuries and microvasculopathy in olfactory tissue. The striking axonal pathology in some cases indicates that olfactory dysfunction in COVID-19 infection may... read more

Risk of Serious Blood Clots Up To 6 Months After COVID-19

Risk of Serious Blood Clots Up To 6 Months After COVID-19

A study from Sweden finds an increased risk of deep vein thrombosis (a blood clot in the leg) up to three months after COVID-19 infection, pulmonary embolism (a blood clot in the lung) up to six months, and a bleeding event... read more

Post COVID-19 Pulmonary Fibrosis

Post COVID-19 Pulmonary Fibrosis

Pulmonary fibrosis is a frequently reported COVID-19 sequela in which the exact prevalence and risk factors are yet to be established. This meta-analysis aims to investigate the prevalence of post-COVID-19 pulmonary fibrosis... read more

Myopericarditis Following COVID-19 Vaccination and Non-COVID-19 Vaccination

Myopericarditis Following COVID-19 Vaccination and Non-COVID-19 Vaccination

The overall incidence of myopericarditis from 22 studies (405,272,721 vaccine doses) was 33·3 cases (95% CI 15·3–72·6) per million vaccine doses, and did not differ significantly between people who received COVID-19... read more

Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19

Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19

Among critically ill patients with COVID-19, treatment with an antiplatelet agent, compared with no antiplatelet agent, had a low likelihood of providing improvement in the number of organ support–free days within 21 days. The... read more

External Chest-wall Compression in Prolonged COVID-19 ARDS with Low-compliance

External Chest-wall Compression in Prolonged COVID-19 ARDS with Low-compliance

SARS-CoV-2 can lead to severe respiratory failure (C-ARDS) with some clinical and radiological characteristics that match the presentation of acute respiratory distress syndrome (ARDS). The management of mechanical ventilation... read more

Prevalence of COVID-19-Associated Pulmonary Aspergillosis

Prevalence of COVID-19-Associated Pulmonary Aspergillosis

First reports of cases and case series of COVID-19-associated pulmonary aspergillosis (CAPA) emerged during the first months of the pandemic. Prevalence rates varied widely due to the fact that CAPA was, and still remains,... read more