External Chest-wall Compression in Prolonged COVID-19 ARDS with Low-compliance

External Chest-wall Compression in Prolonged COVID-19 ARDS with Low-compliance

SARS-CoV-2 can lead to severe respiratory failure (C-ARDS) with some clinical and radiological characteristics that match the presentation of acute respiratory distress syndrome (ARDS). The management of mechanical ventilation... read more

Prevalence of COVID-19-Associated Pulmonary Aspergillosis

Prevalence of COVID-19-Associated Pulmonary Aspergillosis

First reports of cases and case series of COVID-19-associated pulmonary aspergillosis (CAPA) emerged during the first months of the pandemic. Prevalence rates varied widely due to the fact that CAPA was, and still remains,... read more

How Autoimmune Disease Risks Increases After COVID-19

How Autoimmune Disease Risks Increases After COVID-19

The link between COVID-19 infection and development of autoimmune disease is becoming more pronounced, and fields including dermatology are seeking answers to what drives it all. A late-breaking session at the American... read more

tPA for Critically Ill ICU Patients with COVID-19: Does Alteplase Help?

tPA for Critically Ill ICU Patients with COVID-19: Does Alteplase Help?

How do you define a last-ditch effort to save someone's life from COVID-19? Perhaps giving tPA to a severe COVID patient? At this point, I am certain many of us have attempted, with informed consent of course, therapies for... read more

Thromboinflammation and Antithrombotics in COVID-19

Thromboinflammation and Antithrombotics in COVID-19

Thrombotic complications of SARS-CoV-2 infection were recognized early in the pandemic, when infected patients often presented with abnormal coagulation findings and acute macrovascular obstruction, and evidence of pulmonary... read more

Risks and Burdens of Incident Diabetes in Long COVID

Risks and Burdens of Incident Diabetes in Long COVID

In the post-acute phase, we report increased risks and 12-month burdens of incident diabetes and antihyperglycaemic use in people with COVID-19 compared with a contemporary control group of people who were enrolled during... read more

Comparative analysis of the risks of hospitalisation and death associated with COVID-19 variants in England

Comparative analysis of the risks of hospitalisation and death associated with COVID-19 variants in England

The risk of severe outcomes following SARS-CoV-2 infection is substantially lower for omicron than for delta, with higher reductions for more severe endpoints and significant variation with age. Underlying the observed risks... read more

Association Between Dexamethasone Treatment for COVID-19 Patients and Rates of Hospital Readmission and Mortality

Association Between Dexamethasone Treatment for COVID-19 Patients and Rates of Hospital Readmission and Mortality

Current guidelines recommend use of dexamethasone, 6 mg/d, up to 10 days or until discharge for patients hospitalized with COVID-19. Whether patients who received less than 10 days of corticosteroids during hospitalization... read more

Sotrovimab Effect Among High-risk COVID-19 Patients

Sotrovimab Effect Among High-risk COVID-19 Patients

Among nonhospitalized patients with mild to moderate COVID-19 and at risk of disease progression, a single intravenous dose of sotrovimab, compared with placebo, significantly reduced the risk of a composite end point of... read more

Critically Ill Pregnant Women with COVID-19: Management and Outcome

Critically Ill Pregnant Women with COVID-19: Management and Outcome

Coronavirus disease 2019 (COVID-19)-infected pregnant women are at higher risk of intensive care unit (ICU) admission and mechanical ventilation. Because reports describing the clinical course and management of critically... read more

Clinical, Biological and Molecular Aspects of COVID-19

Clinical, Biological and Molecular Aspects of COVID-19

The novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just eight months. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the... read more

Indicators for Monitoring COVID-19 Community Levels and Making Public Health Recommendations

Indicators for Monitoring COVID-19 Community Levels and Making Public Health Recommendations

Widespread uptake of COVID-19 vaccines that are highly effective against severe illness and death, the accrual of high rates of vaccine- and infection-induced immunity at the population level, and the availability of effective... read more

Balanced Crystalloids Probably Reduce Mortality in the Critically-Ill

Balanced Crystalloids Probably Reduce Mortality in the Critically-Ill

As remarked by the authors of the recent PLUS trial, a systematic review and meta-analysis of randomized controlled trials comparing balanced resuscitation fluid to 0.9% saline was reported in the New England Journal of Medicine... read more

Palliative Care Consultation and End-of-life Outcomes in Hospitalized COVID-19 Patients

Palliative Care Consultation and End-of-life Outcomes in Hospitalized COVID-19 Patients

Palliative care consultation was not associated with CPR performed at the end-of-life but was associated with increased incidence of comfort care being utilized. These results suggest that utilizing palliative care consultation... read more