Preventing Major Airway Complications

Every anaesthetist fears the moment they might become faced with a "can't intubate, can't oxygenate" (CICO) scenario, but thankfully such events are exceedingly rare. They nevertheless receive much attention in the academic... read more

The Application of 6S and PDCA Management Strategies in the Nursing of COVID-19 Patients

Overall, the management of the nursing team followed the PDCA (Plan-Do-Check-Act) cycle management principle as described in a previous study, thus enabling real-time planning, execution, inspection and improvement. During... read more

POCUS is Having Its Moment

Ultrasound performed at the point of care (POCUS) is having its moment. The COVID-19 pandemic has seemingly caused the acceleration of POCUS acceptance by hospital leaders, and POCUS examinations are increasingly performed... read more

Factors Associated With Death in Critically Ill Patients With COVID-19 in the US

This study identified demographic, clinical, and hospital-level risk factors that may be associated with death in critically ill patients with COVID-19 and can facilitate the identification of medications and supportive therapies... read more

Moderna mRNA Vaccine Candidate’s Phase I Trial

Eight weeks to the day after press-releasing some top line results, the full paper is out on the Moderna mRNA vaccine candidate’s Phase I trial. I'm very glad to see it – it's going to be very important for the full data... read more

Managing COVID-19 in Hospital Settings

A series of papers to be published across a variety of journals provides a potential roadmap for treating COVID-19 patients within a hospital setting. It tells practitioners in these healthcare environments how to prepare... read more

Research Shows Increased Thrombus Burden in COVID-19 Patients With STEMI

There may be a strong signal towards higher thrombus burden and poorer outcomes in COVID-19 patients presenting with STEMI, supporting the need for establishing COVID-19 status in all STEMI cases, according to a study published... read more

Heparin 2.0: A New Approach to the Infection Crisis

In April 2020, the US Food and Drug Administration granted emergency use authorization for certain medical devices to be used in patients with coronavirus disease 2019 (CO­VID-19). This included extracorporeal blood purification... read more

Elective Tracheostomy During COVID-19: To Whom, When, How?

We suggest to wait at least 14 days to perform tracheostomy. In patients with SOFA score > 6 and D dimer > 4, tracheostomy should not be performed or should be postponed. Optimized procedures and enhanced personal... read more

What We Should Learn From the First Wave of COVID-19

The pace at which the healthcare system has evolved in 2020 has been staggering. What system improvements we sustainably hold on to may be the most important factor in determining our community's future success. We may... read more

COVID-19: How to Quantify and Interpret Treatment Effects in Comparative Clinical Studies

Clinical trials of treatments for coronavirus disease 2019 (COVID-19) draw intense public attention. More than ever, valid, transparent, and intuitive summaries of the treatment effects, including efficacy and harm, are needed.... read more

COVID-19: Airborne Particle Contamination Increased Substantially Using the Aerosol Box

Study shows that aerosol box used to protect healthcare workers during COVID intubation increases, rather than decreases, exposure to airborne particles. A new study shows that aerosol boxes that have been manufactured... read more

Incidence of Pulmonary Embolism in Non-critically ill COVID-19 Patients

Recent studies suggest that thrombotic complications are a common phenomenon in the novel SARS-CoV-2 infection. The main objective of our study is to assess cumulative incidence of pulmonary embolism (PE) in non critically... read more

Increase in Rare Brain Inflammation and Stroke Linked to COVID-19

Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological and neuropsychiatric illness. Responding to this, a weekly virtual coronavirus... read more

Clinical Characteristics of Patients With COVID-19 Receiving Emergency Medical Services

This cohort study of 124 patients with COVID-19 revealed that most patients with COVID-19 presenting to emergency medical services were older and had multiple chronic health conditions. Initial concern, symptoms, and examination... read more

Five COVID-19 Mysteries Scientists Are Still Racing to Solve

Six months and more than ten million confirmed cases later, the COVID-19 pandemic has become the worst public-health crisis in a century. More than 500,000 people have died worldwide. It has also catalysed a research... read more

Safe Performance of Echocardiography During the COVID-19 Pandemic

Coronavirus disease-2019 (COVID-19) outbreak has become a worldwide healthcare emergency, with continuously growing number of infected subjects. Considering the easy virus spread through respiratory droplets produced with... read more

Autopsies Link Immune Response to Death from COVID-19

An autopsy-based study of 11 people who died from COVID-19 shows a mismatch between viral hotspots in the body and sites of inflammation and organ damage, suggesting that immune responses, rather than the virus itself, are... read more

The Ethics of Allocation

One of the greatest challenges in health care - and in generations - is upon us COVID-19 continues to detrimentally affect every aspect of our healthcare system. Clinicians have been faced with grim life-and-death decisions... read more

Why, When, and How to Use Lung Ultrasound During the COVID-19 Pandemic

The COVID-19 pandemic has further highlighted the usefulness of LUS in different clinical scenarios, underlining its advantages in terms of availability, operator- and patient-friendliness, relatively low cost and expertise... read more

Therapeutic Alternatives and Strategies for Drug Conservation in the ICU During Times of Drug Shortage

During the coronavirus disease (COVID-19) global pandemic, urgent strategies to alleviate shortages are required. Evaluation of the feasibility, practicality, and value of drug conservation strategies and therapeutic alternatives... read more

High Risk of Thrombosis in Patients With Severe SARS-CoV-2 Infection

Despite anticoagulation, a high number of patients with ARDS secondary to COVID-19 developed life-threatening thrombotic complications. Higher anticoagulation targets than in usual critically ill patients should therefore... read more