Delirium and long term cognition in critically ill patients

Delirium, a form of acute brain dysfunction, is very common in the critically ill adult patient population. Although its pathophysiology is poorly understood, multiple factors associated with delirium have been identified,... read more

Delirium and long term cognition in critically ill patients

Multicomponent Non-pharmacological Intervention on Delirium and Sleep Quality in SICU

Delirium is a deleterious condition affecting up to 60% of patients in the surgical intensive care unit (SICU). Few SICU-focused delirium interventions have been implemented, including those addressing sleep-wake disruption,... read more

Multicomponent Non-pharmacological Intervention on Delirium and Sleep Quality in SICU

Haloperidol and Quetiapine for the Treatment of ICU-Associated Delirium in a Tertiary Pediatric ICU

In our small, single-center study, patients treated with haloperidol or quetiapine showed no short-term improvement in delirium screening scores after starting treatment when compared with untreated, propensity score-matched... read more

Haloperidol and Quetiapine for the Treatment of ICU-Associated Delirium in a Tertiary Pediatric ICU

Delirium (PRE-DELIRIC) Prediction Model for ICU Patients

The recalibrated PRE-DELIRIC model (version 2) for intensive care patients consists of 10 risk factors that are readily available within 24 hours after intensive care admission and has a high predictive value. The model allows... read more

Delirium (PRE-DELIRIC) Prediction Model for ICU Patients

Haloperidol, Clonidine and Resolution of Delirium in Critically Ill Patients

Haloperidol and clonidine use in delirious ICU patients may be associated with reduced probability of delirium resolution. This finding, however, merits further investigation given inherent limitations of this observational... read more

Haloperidol, Clonidine and Resolution of Delirium in Critically Ill Patients

Delirium Incidence, Duration, and Severity in Critically Ill Patients with COVID-19

Delirium without coma occurred in 29.1% of patients admitted to the ICU. Delirium persisted for a median of 5 days and was severe. Mechanical ventilation was significantly associated with odds of delirium even after adjustment... read more

Delirium Incidence, Duration, and Severity in Critically Ill Patients with COVID-19

Effectiveness of Bundle Interventions on ICU Delirium

This meta-analysis fails to support that bundle interventions are effective in reducing ICU delirium prevalence and duration, but supports that bundle interventions are effective in reducing the proportion of patient-days... read more

Effectiveness of Bundle Interventions on ICU Delirium

Prone Positioning Non-intubated COVID-19 Patients with Severe Hypoxemia Was Safe

In a small sample, prone positioning non-intubated COVID-19 patients with severe hypoxemia was safe; however, many patients did not tolerate prolonged durations. Although patients had improved oxygenation and respiratory... read more

Prone Positioning Non-intubated COVID-19 Patients with Severe Hypoxemia Was Safe

Delirium Prevalence and Risk Factors for Critically Ill COVID-19 Patients

Acute brain dysfunction was highly prevalent and prolonged in critically ill patients with COVID-19. Benzodiazepine use and lack of family visitation were identified as modifiable risk factors for delirium, and thus these... read more

Delirium Prevalence and Risk Factors for Critically Ill COVID-19 Patients

ICU Delirium-Prediction Models: A Systematic Review

Although most ICU delirium-prediction models have relatively good performance, they have limited applicability to clinical practice. Most models were static, making predictions based on data collected at a single time-point,... read more

ICU Delirium-Prediction Models: A Systematic Review

Response to optic nerve sheath diameter guided detection of sepsis associated encephalopathy

regarding the blind method, being uninformed of the clinical diagnoses of patients is unavailing, since clues will still be found in patients' clinical manifestations. Therefore, two trained physicians in intensive ultrasound... read more

Response to optic nerve sheath diameter guided detection of sepsis associated encephalopathy

The Night in the ICU

They say that in the world of the intensive care unit (ICU), there is no night. It can be qualified as a lesser day, but not really as a night. The hustle and bustle may be slower, patient flow and activity may be less, conversations... read more

The Night in the ICU

ICU Delirium Management During SARS-CoV-2 Pandemic

The novel coronavirus, SARS-CoV-2-causing Coronavirus Disease 19 (COVID-19), emerged as a public health threat in December 2019 and was declared a pandemic by the World Health Organization in March 2020. Delirium, a dangerous... read more

ICU Delirium Management During SARS-CoV-2 Pandemic

Effectiveness and Safety of the Awakening and Breathing Coordination, Delirium Monitoring/Management, and Early Exercise/Mobility Bundle

Critically ill patients managed with the Awakening and Breathing Coordination, Delirium monitoring/management, and Early exercise/mobility bundle spent three more days breathing without assistance, experienced less delirium,... read more

Effectiveness and Safety of the Awakening and Breathing Coordination, Delirium Monitoring/Management, and Early Exercise/Mobility Bundle

A Systematic Review of Risk Factors for Sleep Disruption in Critically Ill Adults

This systematic review summarizes all premorbid, illness-related, and ICU-related factors associated with sleep disruption in the ICU. These findings will inform sleep promotion efforts in the ICU and guide further research... read more

A Systematic Review of Risk Factors for Sleep Disruption in Critically Ill Adults

The Pandemic Is a Perfect Storm for ICU Delirium

Spending time in the ICU, especially for anyone with COVID-19, is a dangerous, physically taxing experience: Only the most seriously ill patients land in intensive care, where many undergo a number of complex medical treatments... read more

The Pandemic Is a Perfect Storm for ICU Delirium

Restoring Humanity In The ICU During COVID-19

Machines, tubes, wires, drugs, isolation, confusion... how can we protect the dignity and sanity of our patients when they're at their most vulnerable? Dr. Wes Ely is a Vanderbilt professor and critical care doc who can... read more

Restoring Humanity In The ICU During COVID-19

ICU Doctors Already Know How to Get COVID-19 Patients Off Ventilators Faster

The coronavirus pandemic is instilling chaos that is shaking the world. When intensive care units are running out of ventilators and essential medications, and some 95,000 people die in a matter of a few months, society panics... read more

ICU Doctors Already Know How to Get COVID-19 Patients Off Ventilators Faster

Decrease Delirium in Older ICU Adults Using Music

Researchers from the Regenstrief Institute and Mayo Clinic are leading the first study to test whether exposure to music can decrease delirium in older adults who are receiving mechanical ventilation in the Intensive Care... read more

Decrease Delirium in Older ICU Adults Using Music

ICU Risk Factors and Outcomes for Each Delirium Subtype

Although included studies reported on many subtype-specific risk factors (hypoactive, hyperactive) and outcomes, heterogeneity in reporting and methodological quality limited the generalizability of the results and the evidence... read more

ICU Risk Factors and Outcomes for Each Delirium Subtype

Dancing with Elephants: Mindfulness Training For Those Living With Dementia, Chronic Illness or an Aging Brain

Author Jarem Sawatsky saw the countless guides out there for those caring for the ill and healing the curable, but when he was diagnosed with Huntington's Disease he found there was nothing for those living with incurable... read more

Dancing with Elephants: Mindfulness Training For Those Living With Dementia, Chronic Illness or an Aging Brain