Intensive vs. Conventional Glucose Control in Critically Ill Patients

Intensive vs. Conventional Glucose Control in Critically Ill Patients

n this large, international, randomized trial, we found that intensive glucose control increased mortality among adults in the ICU: a blood glucose target of 180 mg or less per deciliter resulted in lower mortality than did... read more

What constitutes optimal glucose management in Critical Care?

Glycaemic Control in the EU. Following on from the poster we presented at the Intensive Care Society. We asked Sphere Medical's own Dr Gavin Troughton to present at our launch event. In the below video he goes into more... read more

Glycaemic Control Targets After TBI

Glycaemic Control Targets After TBI

This meta-analysis of intensive glycaemic control shows no association with reduced mortality in TBI. Intensive glucose control showed a borderline significant reduction in the risk of poor neurological outcome, but markedly... read more

A comparison of two insulin infusion protocols in the ICU by continuous glucose monitoring

A comparison of two insulin infusion protocols in the ICU by continuous glucose monitoring

The Yale protocol provided better average glycemia, more time spent in normoglycemia, less time in hypoglycemia, and less glycemic variability than the Leuven protocol, but was not independently associated with strict glycemic... read more

Performance of a Modern Glucose Meter in ICU

Performance of a Modern Glucose Meter in ICU

Performance of a Modern Glucose Meter in ICU and General Hospital Inpatients: 3 Years of Real-World Paired Meter and Central Laboratory Results. Due to accuracy concerns, the Food and Drug Administration issued guidance to... read more

The Association of Early Combined Lactate and Glucose Levels with Subsequent Renal and Liver Dysfunction

The Association of Early Combined Lactate and Glucose Levels with Subsequent Renal and Liver Dysfunction

Abnormal combined lactate and glucose measurements may provide an early indication of organ dysfunction. In critically ill patients a 'normal' glucose with an elevated lactate should not be considered desirable, as this combination... read more

Hyperglycaemia in Critically Ill Patients

Hyperglycaemia in Critically Ill Patients

There is an ongoing debate regarding the efficacy of glycaemic control in critically ill patients. Here we briefly highlight the key function of elevated glucose in critically ill patients, namely, to enable elevation of... read more

Airway glucose homeostasis: a new target in the prevention and treatment of pulmonary infection

Airway glucose homeostasis: a new target in the prevention and treatment of pulmonary infection

In health, the glucose concentration of airway surface liquid (ASL) is 0.4mM, around 12 times lower than blood glucose concentration. Airway glucose homeostasis is a set of processes that actively maintain low ASL glucose... read more

The Current State of Glycaemic Control Practice

The Current State of Glycaemic Control Practice

Study involving intensivists from 90 ICUs in northwest Europe confirms significant variability in glycaemic control practices. The study confirmed that there are still controversies over what constitutes optimal glucose management... read more

Tight Glycemic Control in Critically Ill Children

Tight Glycemic Control in Critically Ill Children

In multicenter studies, tight glycemic control targeting a normal blood glucose level has not been shown to improve outcomes in critically ill adults or children after cardiac surgery. Studies involving critically ill children... read more

Sleep Duration Correlated with Lower Odds of Hyperglycemia

Sleep Duration Correlated with Lower Odds of Hyperglycemia

For hospitalized patients, additional sleep and increased sleep efficiency correlate with lower odds of hyperglycemia and impaired fasting glucose. The researchers found that 34 percent of the participants had diabetes, and... read more

Neuroprotective Effects of the Glucagon-Like Peptide-1 Analog Exenatide After Out-of-Hospital Cardiac Arrest

Neuroprotective Effects of the Glucagon-Like Peptide-1 Analog Exenatide After Out-of-Hospital Cardiac Arrest

Acute administration of exenatide to comatose patients in the ICU after OHCA is feasible and safe. Exenatide did not reduce neuron-specific enolase levels and did not significantly improve a composite end point of death and... read more

Hypernatremia (Uggggh!)

Hyponatremia has become a little bit sexy. Not so with sodium that is too high. But I’ve seen a bunch of less than ideal management of hypernatremia, so I figured it is time to put out a podcast about it.... read more

Diabetes monitoring breathalyzer developed

Diabetes monitoring breathalyzer developed

A new hand-held breathalyzer that allows individuals to easily assess their blood glucose levels has been developed. The device informs the user bout diabetes risk and it differs from a medical device we reported on earlier... read more