What’s New in Severe Pulmonary Embolism?

Severe pulmonary embolism (PE) remains a major cause of mortality. For intensivists managing the most "severe" forms of PE, we highlight the main recent advances in the care of such patients including risk stratification,... read more

What’s New in Severe Pulmonary Embolism?

The Myth of Vasopressors and Ischemia

Despite the widespread clinical use, and their well-documented life-saving properties, vasopressors are often maligned, accused of causing ischemia to fingers, toes, mesentery, kidneys, and so forth. Not only is the evidence... read more

The Myth of Vasopressors and Ischemia

The Relationship Between ICU Hypotension and In-hospital Mortality and Morbidity in Septic Patients

Current guidelines recommend maintaining a mean arterial pressure (MAP)≥ 65 mmHg in septic patients. However, the relationship between hypotension and major complications in septic patients remains unclear. We, therefore,... read more

The Relationship Between ICU Hypotension and In-hospital Mortality and Morbidity in Septic Patients

Incidence of hypotension according to the discontinuation order of vasopressors in the management of septic shock

Tapering NE rather than AVP may be associated with a higher incidence of hypotension in patients recovering from septic shock who are on concomitant NE and AVP. However, further studies with larger sample sizes are required... read more

Incidence of hypotension according to the discontinuation order of vasopressors in the management of septic shock

Vasopressors for Hypotensive Shock

This review seeks unbiased evidence about the effects of different drugs that enhance blood pressure on risk of dying in critically ill patients with impaired blood circulation. Review authors identified 28 randomized controlled... read more

Vasopressors for Hypotensive Shock

Hemodynamic Response After Rapid Sequence Induction With Ketamine in Out-of-Hospital Patients at Risk of Shock as Defined by the Shock Index

After ketamine induction, high shock index patients exhibited blunted hypertensive responses and more frequent hypotension, whereas low shock index patients had sustained increases in pulse rate and SBP. One hundred twelve... read more

Hemodynamic Response After Rapid Sequence Induction With Ketamine in Out-of-Hospital Patients at Risk of Shock as Defined by the Shock Index

The Safety of a Novel Early Mobilization Protocol Conducted by ICU Physicians

There are numerous barriers to early mobilization (EM) in a resource-limited intensive care unit (ICU) without a specialized team or an EM culture, regarding patient stability while critically ill or in the presence of medical... read more

The Safety of a Novel Early Mobilization Protocol Conducted by ICU Physicians

The Washington Manual of Critical Care

Prepared by residents and faculty at the Washington University School of Medicine, this pocket manual contains easy-to-read algorithms for the management of more than 80 medical and surgical problems arising in the intensive... read more

The Washington Manual of Critical Care

Should We Manage All Septic Patients Based on a Single Definition?

It is indisputable from the biological and clinical perspectives that not all cases of sepsis are the same. On the contrary, most have great many differences, that is, different portals of entry, clinical manifestations,... read more

Should We Manage All Septic Patients Based on a Single Definition?

Eye Protection in Anaesthesia and Intensive Care

New guidelines on prevention of eye injuries during anaesthesia and intensive care have been developed by the French Society for Anaesthesia and Intensive Care Medicine (SFAR), together with the French Ophthalmology Society... read more

Eye Protection in Anaesthesia and Intensive Care

Hypoxia and Hypotension in Patients Intubated by Physician Staffed Helicopter EMS

The effective treatment of airway compromise in trauma and non-trauma patients is important. Hypoxia and hypotension are predictors of negative patient outcomes and increased mortality, and may be important quality indicators... read more

Hypoxia and Hypotension in Patients Intubated by Physician Staffed Helicopter EMS

Cardiohepatic Interactions in Heart Failure

Liver involvement in chronic heart failure has long been recognized and reflects the systemic hemodynamic changes that occur during the evolution of heart failure syndrome. Apart from venous congestion and backward failure,... read more

Cardiohepatic Interactions in Heart Failure

Risk of AKI After Intravenous Contrast Media Administration

In the largest well-controlled study of acute kidney injury (AKI) following contrast administration in the ED to date, intravenous contrast was not associated with an increased frequency of acute kidney injury. Rates of acute... read more

Risk of AKI After Intravenous Contrast Media Administration

A Better Way to Detect Sepsis in Kids in the ED

We have been interested in this question for a long time here at CHOP and have done several interventions over the past several years to try to improve our ability to recognize children with septic shock. When we started... read more

A Better Way to Detect Sepsis in Kids in the ED

A multicenter, randomized trial of a checklist for endotracheal intubation of critically ill adults

The verbal performance of a written, pre-procedure checklist does not increase the lowest arterial oxygen saturation or lowest systolic blood pressure during endotracheal intubation of critically ill adults compared to usual... read more

A multicenter, randomized trial of a checklist for endotracheal intubation of critically ill adults

Low-volume Resuscitation with Normal Saline is Associated with Microvascular Endothelial Dysfunction After Hemorrhage

Low-volume resuscitation with normal saline is associated with microvascular endothelial dysfunction after hemorrhage in rats, compared to colloids and balanced crystalloids. Resuscitation with NS failed to inhibit syndecan-1... read more

Low-volume Resuscitation with Normal Saline is Associated with Microvascular Endothelial Dysfunction After Hemorrhage

Video vs direct laryngoscopy in the ICU: are we asking the right question?

Endotracheal intubation in the operating room (OR) and the ICU are different procedures, but this is not always recognized. The ICU patient should be evaluated as a physiologically difficult airway, in contrast to the traditional... read more

Video vs direct laryngoscopy in the ICU: are we asking the right question?

Blood pressure deficits in acute kidney injury: not all about the mean arterial pressure?

Acute kidney injury (AKI) is associated with increased morbidity and mortality. Although there are many causes of AKI, it is known that patients undergoing high-risk surgery are known to be at significant risk. Although much... read more

Blood pressure deficits in acute kidney injury: not all about the mean arterial pressure?