Impacts of Initial ICU Driving Pressure on Outcomes in Acute Hypoxemic Respiratory Failure

Driving pressure (DP) is a marker of severity of lung injury in patients with acute respiratory distress syndrome (ARDS) and has a strong association with outcome. However, it is uncertain whether limiting DP can reduce... read more

The Pathophysiology of Happy Hypoxemia in COVID-19

The novel coronavirus disease 2019 (COVID-19) pandemic is a global crisis, challenging healthcare systems worldwide. Many patients present with a remarkable disconnect in rest between profound hypoxemia yet without proportional... read more

Adjusting risk of AKI for Time on Controlled Mechanical Ventilation in ARDS

The authors expressed concerns that the study did not account for certain key covariates, such as septic shock, right heart failure, or hypoxemia, which are believed to influence the development of AKI. We would like... read more

Oxygen Therapy and Noninvasive Respiratory Supports in Acute Hypoxemic Respiratory Failure

Whereas oxygen supplementation should be initiated for patients with acute hypoxemic respiratory failure defined as PaO2 below 60 mm Hg or SpO2 ... read more

Optimizing Oxygenation For Tracheal Intubation in Critically Ill Patients

Tracheal intubation (TI) is a common procedure frequently performed in critically ill patients and is an integral part of emergency airway management (EAM). However, it carries inherent risks and can significantly impact... read more

Oxygen Therapy in Acute Hypoxemic Respiratory Failure

Although largely used, the place of oxygen therapy and its devices in patients with acute hypoxemic respiratory failure (ARF) deserves to be clarified. The French Intensive Care Society (Société de Réanimation de Langue... read more

A prediction model for nonresponsive outcomes in critically ill patients with ARDS undergoing prone position ventilation

In this study, a risk prediction model for nonresponse to prone position ventilation in acute respiratory distress syndrome (ARDS) patients was constructed, which demonstrated good predictive value and clinical utility. Early... read more

Navigating the Complexity of ECMO and Positioning in ARDS Treatment

We read with great interest the network meta-analysis by Sud et al. comparing venovenous extracorporeal membrane oxygenation (VV-ECMO), prone positioning, and supine mechanical ventilation in patients with severe hypoxemic... read more

Noninvasive Ventilation for Preoxygenation during Emergency Intubation

Among critically ill adults undergoing tracheal intubation, preoxygenation with noninvasive ventilation resulted in a lower incidence of hypoxemia during intubation than preoxygenation with an oxygen mask. Among the 1,301... read more

Textbook of Ventilation, Fluids, Electrolytes and Blood Gases

Textbook of Ventilation, Fluids, Electrolytes and Blood Gases

The Textbook of Ventilation, Fluids, Electrolytes and Blood Gases encompass essential topics for which thorough education and training is a must for any clinician who manages these patients. This book has four sections, each... read more

Extracorporeal Life Support for Adults

Extracorporeal Life Support for Adults

This book presents a concise, evidence-based review of extracorporeal life support (ECLS) for adult diseases. It describes the use of ECLS with patients who are experiencing severe hypoxemic respiratory failure (ARDS and... read more

EEG Patterns for Predicting Poor Outcome After Cardiac Arrest

EEG Patterns for Predicting Poor Outcome After Cardiac Arrest

The specificity of the ERC-ESICM-recommended EEG patterns for predicting poor outcome after cardiac arrest exceeds 90% but is lower than in previous studies, suggesting that large-scale implementation may reduce their accuracy.... read more

Dyspnea and Dyspnea-Associated Anxiety in ICU Patients

Dyspnea and Dyspnea-Associated Anxiety in ICU Patients

Dyspnea is frequently associated with anxiety, prolonged days on mechanical ventilation, and worse quality of life after discharge. It can also increase the risk of posttraumatic stress disorder post ICU discharge. However,... read more

Heat Shock Protein 27 in COVID-19 and non-COVID ARDS Pathogenesis

Heat Shock Protein 27 in COVID-19 and non-COVID ARDS Pathogenesis

Acute respiratory distress syndrome (ARDS) is a common cause of hypoxemic respiratory failure in intensive care units that has increased dramatically as a result of the COVID-19 pandemic. In both COVID-19 and non-COVID... read more

Pediatric Sepsis Phenotype with Persistent Hypoxemia, Encephalopathy, and Shock

Pediatric Sepsis Phenotype with Persistent Hypoxemia, Encephalopathy, and Shock

We derived and validated the persistent hypoxemia, encephalopathy, and shock phenotype, which is highly reproducible, clinically relevant, and associated with HTE to common adjuvant therapies in children with sepsis. We... read more

HFNC vs. CPAP in COVID-19 Patients with ARDS in ICU

HFNC vs. CPAP in COVID-19 Patients with ARDS in ICU

Acute hypoxic respiratory failure in coronavirus disease 2019 (COVID-19) pneumonia has been treated with oxygen delivered by oxygen masks and non-invasive ventilation (NIV) with continuous positive airway pressure (CPAP),... read more