Severe Listeriosis in the ICU: Critical Insights from a Multicenter Study

A retrospective multicenter study across 23 French hospitals over 10 years analyzed critically ill ICU patients with culture-confirmed "Listeria monocytogenes" infections. The study aimed to describe patient characteristics,... read more

Seraph-100 Hemoperfusion: Clearing Pathogens and Enhancing Outcomes in Sepsis

This study evaluated Seraph-100 hemoperfusion (HP) as a treatment for sepsis in intensive care unit (ICU) patients admitted after cardiac surgery for infective endocarditis (IE). Thirteen septic patients received Seraph-100... read more

Push-Dose Epinephrine Use in the Emergency Department

A retrospective multi-site cohort study investigated the use of push-dose epinephrine (PDE) in emergency departments (EDs) for managing hypotension in critically ill patients. Recognizing the limited ED-specific data compared... read more

Impact of Esketamine vs. Remifentanil on Hemodynamics and Outcomes in Mechanically Ventilated Septic Shock

This single-center, prospective, randomized, controlled pilot study compared the hemodynamic effects and prognosis of esketamine versus remifentanil, both used in combination with propofol, for sedation and analgesia in patients... read more

Vitamin D Dynamics in Severe ARDS Patients on ECMO

This retrospective study investigated time-dependent changes in vitamin D levels and their correlation with disease severity and inflammation in 24 invasively mechanically ventilated patients with acute respiratory distress... read more

Troponin HsTnI: Predicting Outcomes in Covid-19 Patients

This observational retrospective cohort study of 325 patients diagnosed with COVID-19 aimed to determine the relationship between troponin levels and disease severity or mortality. Conducted at Mohammed VI CHU in Oujda... read more

Non-invasive Mechanical Ventilation in Critical Care, Anesthesiology and Palliative Care

This book provides an easy, modern and practical way for physicians to approach the world of noninvasive mechanical ventilation (NIMV). Noninvasive ventilation is well-established and increasingly used in routine clinical... read more

Non-invasive Mechanical Ventilation in Critical Care, Anesthesiology and Palliative Care

Finding the Ultimate Sedative

Critically ill patients requiring invasive mechanical ventilation often need continuous sedation for pain and anxiety. Propofol, a GABA potentiator, and Dexmedetomidine, an α2-adrenergic receptor agonist, are commonly used... read more

Early Multimodal Rehabilitation Safely Accelerates Recovery for Ventilated Patients

This single-center, controlled clinical trial investigates the efficacy and safety of an early multimodal rehabilitation program (MRP) versus a late MRP in mechanically ventilated adult patients in the intensive care unit... read more

Propofol vs. Midazolam Infusion: Effects on Cardiovascular Stability in Critically Ill Patients

A study compared the effects of propofol and midazolam infusions on cardiovascular stability in 75 critically ill patients requiring sedation in the intensive care unit at Azadi and Tikrit Teaching Hospitals from December... read more

Causes of Death in Patients Undergoing ECPR

Refractory shock was the leading cause of death among our cohort of extracorporeal cardiopulmonary resuscitation (ECPR) patients, followed closely by neurological complications, while other causes are rare. In this post-hoc... read more

Mechanical Power Impact Normalized to Predicted Body Weight on Outcomes in Pediatric ARDS

Higher mechanical power (MP) was associated with fewer ventilator (VFD) and ICU free days (IFD). The causal effect of MP on VFD and IFD was fully mediated by the impairment in oxygenation. This is a post-hoc analysis of... read more

Anticoagulation Reversal Strategies for Warfarin Associated Acute Gastrointestinal Bleeding

Patients who received prothrombin complex concentrate (PCC) had a threefold increase in mortality compared to fresh frozen plasma (FFP), vitamin K alone, or no reversal, even after adjusting for severity of the bleeding.... read more

Endotracheal Tube Cuff Pressure Monitoring and VAP Occurrence

This study demonstrated that maintaining endotracheal tube cuff pressure at 30 cm H2O through monitoring every 8 h did not result in a greater incidence of under-inflation (pressures ... read more

Association Between Initial Blood Product Transfusion with a Higher Plasma-to-red Blood Cell Ratio and Mortality in Adults with Severe Bleeding Following Trauma

This study demonstrates that a high fresh-frozen plasma (FFP) to packed red blood cells (PRBC) ratio (>1:1.5) is associated with reduced 24-hour and 30-day mortality rates among trauma patients with massive hemorrhage. However,... read more

Intubating the Critically Ill Patient: A Step-by-Step Guide for Success in the ED and ICU

Intubating critically ill patients is a process that requires a well-thought-out, step-by-step plan, specific to each patient. This book teaches the steps necessary to predict, prepare, perform, and provide pre and post-intubation... read more

Intubating the Critically Ill Patient: A Step-by-Step Guide for Success in the ED and ICU

Hemodynamic Stabilization Using CRRT and cIVNa Combination Therapy

Compared with conventional continuous renal replacement therapy (CRRT), combination therapy of CRRT and continuous intravenous sodium infusion therapy (cIVNa) increased blood pressure, enhanced urinary volume, and reduced... read more

Hemodynamic Monitoring in the ICU

This book describes the pathophysiological significance of the hemodynamic monitoring parameters available to the clinician and their role in providing reliable and reproducible information on the cardiocirculatory status... read more

Hemodynamic Monitoring in the ICU

A Novel Mechanism for COVID-19 Related Thrombotic Events: Platelet NO/ROS Equilibrium

The finding that platelet NO/ROS production imbalance contributes to the elevated risk of thrombotic events in COVID-19 has important clinical implications. Restoration of platelet NO production, as well as attenuation... read more

Inadequate Empirical Antibiotic Therapy in VAP: Risk Factors and Outcomes

Ventilator-associated pneumonia (VAP) caused by MDR pathogens were highly likely to receive inadequate empirical antibiotic therapy. The mortality rate and intubation duration were significantly longer in inadequately treated... read more

Early Acetaminophen Administration Associated with Lower Mortality Among ARDS Patients After Coronary Artery Bypass Grafting

The use of acetaminophen (APAP) at 48h after coronary artery bypass grafting (CABG)-acute respiratory distress syndrome (CABG-ARDS) was associated with lower early postoperative mortality, while shortening the length of hospital... read more

Thirst Management in Orotracheally Intubated and Mechanically Ventilated Patients

Symptom Management Theory (SMT)-based thirst management is an effective strategy. The 5 mL cold water spray method significantly reduces thirst intensity and distress in mechanically ventilated patients under fasting and... read more