Tag: ICU
Precision at Scale: Automating the SOFA Score for Smarter ICU Care
The Sequential Organ Failure Assessment (SOFA) score is a vital tool for diagnosing sepsis and predicting patient outcomes in the ICU, but its manual calculation is often plagued by human error and scalability issues. To... read more
COVID-19 in the Air: The Hidden Viral Footprint in Hospital Waiting Rooms
New research from the Kirby Institute reveals that COVID-19 genetic material is frequently present in hospital air during community outbreaks, even in facilities with high-quality ventilation. By sampling air and surfaces... read more
Breaking the Silos: How a Federated Europe Could Solve the Sepsis Puzzle
The landscape of critical care research is currently hindered by "data silos"—isolated pockets of patient information that are difficult to share due to privacy concerns and technical incompatibility. This narrative review... read more
Echocardiography for Intensivists
This book contains all the information that readers will require in order to perform echocardiography and to interpret the findings correctly. After an introductory chapter on the essential physics of ultrasonography,... read more
Power to the Patient: Rethinking Pain Control in the ICU
This scoping review of 12 relevant studies suggests that Patient-Controlled Analgesia (PCA) offers a promising path toward faster and more stable pain management for ICU patients. By allowing patients to self-administer small... read more
Balancing the Breath: Navigating the Brain-Lung Connection in Acute Brain Injury
This study explores the delicate tug-of-war between mechanical ventilation (MV) and outcomes for patients with Acute Brain Injury (ABI). The researchers highlight that the way we breathe for a patient can significantly influence... read more
The Great Escape: How ECMO Weaning Shifts Antibiotic Levels
This case study explores the complex pharmacological landscape of treating a 47-year-old patient with severe renal impairment and pneumonia using ceftazidime–avibactam (CAZ-AVI) while on VA-ECMO support. Researchers... read more
Life After the Pump: Quality of Life in Cardiac Surgery Survivors
Researchers have conducted a major study—the largest of its kind for this specific population—investigating the long-term quality of life (QoL) for patients who survived post-cardiotomy cardiogenic shock (PC-CS). By... read more
The Kidney Crisis: Acute Injury as a Predictor of ICU Survival
This extensive population-level study from Ontario, Canada, analyzed over 480,000 adult ICU admissions to clarify the relationship between Acute Kidney Injury (AKI) and patient outcomes. By utilizing outpatient baseline data... read more
Predicting Sepsis-associated Encephalopathy in Septic ICU Patients with AKI
Researchers developed a simple, interpretable nomogram to predict sepsis-associated encephalopathy (SAE) on day 1 in septic ICU patients who also have acute kidney injury (AKI), using data from the large MIMIC-IV database... read more
Metabolic Acidosis Worsens Cardiac Function and Vasopressor Needs in Septic Shock
In a prospective observational study conducted from January to December 2024 at Hospital de Especialidades No. 14, IMSS, in Veracruz, Mexico, researchers examined the cardiovascular effects of acute metabolic acidemia in... read more
Corrected Serum Calcium Levels Predict 28-Day Death Risk in Sepsis
In a large cohort study utilizing data from 7,627 sepsis patients in the eICU Collaborative Research Database, researchers uncovered a clear U-shaped relationship between corrected serum calcium (sCa) levels and 28-day mortality.... read more
Integration Equals Separation for CRRT Filter Lifespan in ECMO Patients (E-CRRT Trial)
The multicenter randomized controlled E-CRRT Trial, conducted from May 2021 to March 2025 at King Chulalongkorn Memorial Hospital (KCMH) and Central Chest Institute of Thailand (CCIT), compared two strategies for combining... read more
Sepsis: Definitions, Pathophysiology and the Challenge of Bedside Management
A comprehensive and state-of-the-art resource for clinicians who care for patients with sepsis and research scientist alike. Patients with severe sepsis requiring ICU admission have very high rates of ICU and overall... read more
Neostigmine’s Anti-Inflammatory Edge: Cholinergic Boost Slashes Cytokines, Organ Failure, and Mortality in Septic Shock
In a randomized controlled trial, researchers investigated the adjuvant use of continuous neostigmine infusion (0.2 mg/hr for 5 days) in patients with septic shock, leveraging its ability to enhance vagal cholinergic anti-inflammatory... read more
Bedside Procedures for the Intensivist
Bedside Procedures for the Intensivist delivers practical tips and clear, step-by-step instruction on the most common procedures in the ICU. The convenient and portable handbook focuses on ultrasound-guided techniques, including... read more
The Pressure to Survive: Why Peak BP Matters for the Oldest ICU Patients
This binational cohort study analyzed 219 patients aged 90 and older who were admitted to the ICU following an in-hospital cardiac arrest. While clinical focus often shifts to average or minimum blood pressure, this research... read more
The Dangerous Duo: How Delirium Compounds Risks in Acute Kidney Injury
This systematic review and meta-analysis of over 158,000 critically ill patients reveals a significant link between Acute Kidney Injury (AKI) and delirium, affecting approximately 32% of patients with AKI. The study found... read more
Blood Pressure Disorders in Acute and Chronic Kidney Diseases (Updates in Hypertension and Cardiovascular Protection)
This new book is intended to be an in-depth and up-to-date guide to the various aspects of the association between blood pressure disorders and acute/chronic renal diseases. In addition, this work includes discussion... read more
AI Foresees the Squeeze: Machine Learning Predicts Vasopressor Needs Hours Ahead in Sepsis Patients
This proof-of-concept retrospective study, utilizing the MIMIC-IV v2.2 database (2008–2019), demonstrates that an interpretable machine learning model based on routinely collected electronic health record data from ICU... read more
Urinary Source Saves Lives: Why Infection Origin Matters in Septic Shock for Patients Over 90
In critically ill nonagenarians and centenarians admitted to ICUs with septic shock, the source of infection emerges as a key independent predictor of long-term survival, varying over time. Patients with septic shock from... read more
Less Steroids, Better Outcomes: High-Dose Corticosteroids Harm ICU COPD Patients
A large pharmacoepidemiologic cohort study of over 17,000 US patients admitted directly to ICUs for acute exacerbations of COPD revealed that two-thirds received high-dose systemic corticosteroids (>240 mg/day methylprednisolone... read more
