Serum MANF vs. Severity and Prognosis in Community-acquired Pneumonia Patients

This evidence demonstrated that serum mesencephalic astrocyte-derived neurotrophic factor (MANF) is positively associated with scoring criteria and poor prognosis in community-acquired pneumonia (CAP) patients. Serum... read more

Tocilizumab vs. IVIG in Patients with Severe COVID-19 Pneumonia

Severe COVID-19 patients who received IVIG in the early phase of the disease did not show better clinical outcomes in terms of mortality, hospitalization time and intensive care unit admission compared to those who received... read more

Management of Chest Trauma: A Practical Guide

75% of patients who die from trauma have injuries to the chest. The care of the chest trauma patient can be incredibly complex, require multiple specialty and sub-specialty services, and may require interventions available... read more

Management of Chest Trauma: A Practical Guide

Holy Water Not so Holy: Potential Source of Elizabethkingia Pneumonia and Bacteremia in an Immunocompromised Host

This case report highlights that E. anophelis may indeed cause significant infection and should not be considered a contaminant especially in immunosuppressed individuals. The organism originates from water sources and may... read more

Levosimendan Role in ECMO for Refractory Cardiac Arrest

Levosimendan use in extracorporeal cardiopulmonary resuscitation (ECPR) did not improve survival. Neurological outcome could be representative of the short- and long-term outcomes. Future well-designed randomized trials... read more

Fever Management with or without a Temperature Control Device After OHCA and Resuscitation

the TEMP‐CARE trial will advance our understanding of post‐cardiac arrest care fever management strategies. With a large sample size and a broad patient population, the results of this trial will inform clinical practice... read more

50 Landmark Papers Every Intensivist Should Know

This book identifies the key scientific articles in the field of Intensive Care and explains why these papers are important in contemporary clinical management. Identifying those influential contributors who have shaped... read more

50 Landmark Papers Every Intensivist Should Know

Ventilator-associated Pneumonia Pathogenesis: Old and New Mechanisms

Ventilator-associated pneumonia (VAP), defined as a lung infection that occurs in patients after 48 hours on mechanical ventilation, is among the most frequently found nosocomial infections in intensive care units around... read more

Aminoglycosides Impact on Survival Rate and Renal Outcomes in Patients with Urosepsis

The addition of aminoglycosides to beta-lactam therapy in critically ill patients with urosepsis did not significantly improve 30-day survival. Furthermore, aminoglycosides were not associated with worse renal outcomes.... read more

Clinical Respiratory Anatomy and Physiology in the ICU: Anatomophysiopathology and gasometry of patients on invasive mechanical ventilation

Breathing is a physiological process that is fundamental to life. The respiratory system can be likened to a vital pump allowing the exchange of gases between the cells of an organism and the external environment. A number... read more

Clinical Respiratory Anatomy and Physiology in the ICU: Anatomophysiopathology and gasometry of patients on invasive mechanical ventilation

Wireless Wearable Doppler Ultrasound: Monitoring Trauma Patients

This study demonstrated the feasibility of placing the wireless, wearable Doppler ultrasound on severely injured trauma patients admitted to the trauma bay of a busy level 1 trauma center. The device reliably captured... read more

Weaning Failure Prediction Using Electrocardiographic Time-frequency Analysis and Respiration Flow Signals

Weaning patients from mechanical ventilation (MV) is a crucial process that requires meticulous assessment of their ability to breathe independently without ventilatory assistance. Spontaneous breathing test (SBT) is... read more

Anesthesia Role in Sedation and Weaning From Mechanical Ventilation

This systematic review highlights the advantages of anesthetic sedation strategies, particularly the use of dexmedetomidine, methadone, or sequential sedation protocols, in improving weaning outcomes, enhancing sedation quality,... read more

Dexmedetomidine Use for Palliative Sedation in Non-ICU Settings

Dexmedetomidine is a promising adjunct to be considered for palliative sedation when managing end-of-life symptoms such as refractory pain, anxiety, or delirium. This medication should be considered a reasonable alternative... read more

Clinical Characteristics and Survival Outcomes of Invasive Pulmonary Aspergillosis Patients

Invasive pulmonary aspergillosis (IPA) is a severe infectious disease caused by Aspergillus spp. It is associated with high mortality, particularly in immunocompromised patients, as well as in those with COVID-19 pneumonia... read more

Improving Critical Care Survivorship: A Guide to Prevention, Recovery, and Reintegration

This book, just published, provides a comprehensive overview of improving critical care survivorship. Comprised of four sections, the text presents interventions that can be used to improve patient outcomes and reduce the... read more

Improving Critical Care Survivorship: A Guide to Prevention, Recovery, and Reintegration

Baricitinib Use in Children with Severe COVID-19 Infection

Baricitinib appears safe for both immunocompetent and immunocompromised children hospitalized for severe COVID-19. Most adverse events did not inhibit therapy administration, and there were no deaths following the initiation... read more

Analgosedation Practice During Noninvasive Respiratory Supports

Sedation is frequently used in patients with acute respiratory failure (ARF) undergoing Noninvasive Respiratory Supports (NRSs). Current analgesic practices are becoming more standardized, with analgosedation strategies increasingly... read more

Lung-protective Ventilation Strategies for Mechanical Ventilation

This study is an important step toward optimizing mechanical ventilation strategies, addressing the interplay between mechanical power, gas exchange and long-term respiratory outcomes could further refine lung-protective... read more

Early Initiated Noradrenaline vs. Fluid Therapy for Hypotension and Shock

The VASOSHOCK trial is a pragmatic, multi-center, superiority, randomized controlled trial investigating early initiation of peripheral noradrenaline in hypotension and shock, investigating the impact of this treatment on... read more

Severe Adenoviral Infections: Disease Progression and Poor Prognostic Markers

Low hemoglobin, high serum ferritin, and high LDH in the second week are markers of disease progression and poor prognostic markers in severe adenoviral infections, emphasizing further research and targeted interventions. The... read more

Increased Sodium Levels Associated with Ceftriaxone Administration

Serum sodium elevation is considered a frequent manifestation in critically ill patients, with significant clinical outcomes and requiring timely management. This case report suggests a possible association between the... read more