ICU Trends for Patients with COVID-19 in England, Wales and Northern Ireland

Observed trends suggest opposing effects of ICU strain and clinical learning. Further investigation is needed to identify modifiable system factors that could alleviate strain in future epidemics and changes in clinical practice... read more

The Night in the ICU

They say that in the world of the intensive care unit (ICU), there is no night. It can be qualified as a lesser day, but not really as a night. The hustle and bustle may be slower, patient flow and activity may be less, conversations... read more

Automated vs. Conventional Ventilation in the ICU

Automated ventilation (AV) appears to reduce the incidence and severity of blood oxygen desaturation during daily nursing procedures (DNPs) in comparison to Conventional Ventilation (CV). Of the 265 included patients,... read more

Quetiapine Decreases Mortality and Improve Neurological Outcomes in Critically-ill TBI Patients

Quetiapine may decrease mortality and improve neurological outcomes in critically-ill traumatic brain injury (TBI) patients. It has a dose-dependent effect to decrease intracranial pressure (ICP) and increase cerebral perfusion... read more

ICU Doctor Creates App to Help Patients on Ventilators Communicate Faster

ICU Doctor Chandar Abboy and his partner came up with a way to give a voice to the voiceless. The app called “Yo Doc” allows patients on ventilators to better communicate their needs and feelings. Dr. Abboy says this... read more

Anaphylatoxin C5a Impairs Phagocytosis by Neutrophils

This study provides new insight into the mechanisms underlying immunocompromise in critical illness and suggests novel avenues for therapy and prevention of nosocomial infection. Critically ill patients are at heightened... read more

Association Between Anxiety and New Organ Failure, Independently of Critical Illness Severity and Respiratory Status

Moderate to severe anxiety at ICU admission is associated with early occurrence of new organ failure in critically ill patients, independently of respiratory status and severity of critical illness. The causality link could... read more

Lange Critical Care

LANGE Critical Care delivers concise, evidenced-based, and highly clinical coverage of the surgical and medical aspects of critical care. The book provides basic fundamentals, applications and insights that will be of lasting... read more

Lange Critical Care

Working in ICU is like Flying a Plane: The Secret World of Intensive Care

Stepping on to the ICU during this period was like entering another world. In a way intensive care has always seemed like a place removed from life outside said Mike Brunner, an intensive care doctor at Northwick Park hospital... read more

Aerosol and Surface Distribution of SARs-CoV-2 in Hospital Wards

In a hospital treating COVID-19 patients, SARS-CoV-2 RNA was found widely distributed in surface and air samples. Contamination was greater in intensive care units (54/124 samples) than general wards (9/114 samples). A... read more

Is it Safe to Look Yet?

As we start to move to the next stage of the COVID-19 pandemic, it feels like a moment to take stock. The country has gone through huge changes to our way of life over the last few months, and those changes have been mirrored... read more

A Guide to Performance Evaluation for the Intensivist

Currently, there is no standard process to develop Ongoing Professional Practice Evaluation and Focused Professional Practice Evaluation processes in critical care medicine. Departments and institutions can tailor metrics... read more

Longitudinal Analyses Reveal Immunological Misfiring in Severe COVID-19

Recent studies have provided insights into the pathogenesis of COVID-19. Yet, longitudinal immunological correlates of disease outcome remain unclear. Here, we serially analysed immune responses in 113 COVID-19 patients with... read more

High Breath-by-Breath Variability Is Associated With Extubation Failure in Children

High respiratory variability during spontaneous breathing trials is independently associated with extubation failure in children, with very high rates of extubation failure when these children develop postextubation upper... read more

Presence of Genetic Variants Among Young Men With Severe COVID-19

In this case series of 4 young male patients with severe COVID-19, rare putative loss-of-function variants of X-chromosomal TLR7 were identified that were associated with impaired type I and II IFN responses. These preliminary... read more

Who Gets to Live? How Doctors Make Impossible Decisions as COVID-19 Surges

Triage aims to provide the greatest amount of good for the greatest number, but medical staff are grappling with how to stay true to this principle as coronavirus surges. 18 states are currently in what's considered the... read more

Risks Of VAP in Patients With Viral ARDS Related or Not To COVID-19

In this retrospective case-control study, we have observed a higher prevalence of ventilator-associated pneumonia (VAP) and MDR VAP in C-ARDS as compared with NC-ARDS patients. Further, probably multicenter, research work... read more

Factors Associated With Death in Critically Ill Patients With COVID-19 in the US

This study identified demographic, clinical, and hospital-level risk factors that may be associated with death in critically ill patients with COVID-19 and can facilitate the identification of medications and supportive therapies... read more

Infectious Meningitis and Encephalitis in ICU

Infectious meningitis and encephalitis are a major concern in ICU since they are associated with high mortality and permanent neurological injury. About 3% of central nervous system infections will be admitted in the ICU. Three... read more

Managing COVID-19 in Hospital Settings

A series of papers to be published across a variety of journals provides a potential roadmap for treating COVID-19 patients within a hospital setting. It tells practitioners in these healthcare environments how to prepare... read more

Approach to New Fever or Rigors in the ICU Patient

Failure to recognize neutropenic fever as a separate entity that requires immediate treatment. Routinely ordering urinalysis and sputum cultures (for most patients, this will only lead to false-positive results and unnecessary... read more

Elective Tracheostomy During COVID-19: To Whom, When, How?

We suggest to wait at least 14 days to perform tracheostomy. In patients with SOFA score > 6 and D dimer > 4, tracheostomy should not be performed or should be postponed. Optimized procedures and enhanced personal... read more