Process Monitoring in the ICU

Throughout a patient's stay in the Intensive Care Unit (ICU), accurate measurement of patient mobility, as part of routine care, is helpful in understanding the harmful effects of bedrest. However, mobility is typically measured... read more

Saving Lives in the ICU Through Artificial Intelligence

Hospitals today run according to evidence-based medicine. That makes for smart science. But for critical care, it can be a problem. A patient may appear normal, but if you had a sign that, in two to three hours, that patient... read more

How The Burn Trauma ICU Eliminated Central Line Infections

Is zero possible? In the case of central line infections, the answer was once no. A CLABSI (central line associated blood stream infection) was once considered a car crash, or an expected inevitability of care. When University... read more

Danger Signals in the ICU

Damage-associated molecular pattern activation and release is an important research for intensive care practitioners. It will add to our understanding of the phase and state of the innate immune response to an insult. Early... read more

Cardiac Output Monitoring: Throw it Out… or Keep it?

In critical care units, the shelf for cardiac output (CO) monitoring devices fills up with ever more innovative systems. Are these techniques useful, or are they expensive and irrelevant gadgets? There are arguments to defend... read more

An Exploratory Reanalysis of the Randomized Trial on Efficacy of Corticosteroids as Rescue Therapy for the Late Phase of ARDS

During active intervention, methylprednisolone was safe and effective in achieving disease resolution. Our findings support rapid glucocorticoid discontinuation post extubation as likely cause of disease relapse. Gradual... read more

Diagnostic Accuracy of Delirium Assessment Methods in Critical Care Patients

Delirium is a disorder of decreased ability to focus, sustain or shift attention, change in cognition and or perception. The main objective was to evaluate the diagnostic accuracy of Confusion Assessment Method for the ICU... read more

Concise Review of Critical Care, Trauma and Emergency Medicine

A Quick Reference Guide of ICU and Er Topics. Most commonly encountered clinical scenarios and relevant topics are summarized in an easy to understand format. Can be used as quick reference guide during rounds, or during... read more

Concise Review of Critical Care, Trauma and Emergency Medicine

Prone Positioning of ARDS Patients

A prospective international observational prevalence study on prone positioning of ARDS patients: the APRONET (ARDS Prone Position Network) study. While prone positioning (PP) has been shown to improve patient survival in... read more

On Diagnosing Sepsis

Two years ago, a panel appointed by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine, referred to as a consensus conference, proposed a new definition for sepsis and new diagnostic... read more

Animal-assisted Intervention in the ICU: A Tool for Humanization

The combination of an aging population and advances in critical care medicine is resulting in a growing number of survivors of critical illness. Survivors' descriptions of their stay in an intensive care unit (ICU) are frequently... read more

Trends of Incidence and Risk Factors of VAP in Elderly Patients Admitted to French ICUs

This study assesses trends and risk factors of ventilator-associated pneumonia (VAP) according to age, particularly in the elderly admitted to French ICUs between 2007 and 2014. Ventilator-associated pneumonia incidence is... read more

Distributions and Behavior of Vital Signs in Critically Ill Children by Admission Diagnosis

This is the first study reporting distributions of continuously measured physiologic variables and trends in their behavior according to admission diagnosis in critically ill children. Differences detected between and within... read more

Is Overall Mortality the Right Composite Endpoint in Clinical Trials of ARDS?

Most deaths in acute respiratory distress syndrome (ARDS) patients are not directly related to lung damage but to extrapulmonary multisystem organ failure. It would be challenging to prove that specific lung-directed therapies... read more

Persistence of Delirium after Cessation of Sedatives and Analgesics and Impact on Clinical Outcomes in Critically Ill Patients

As delirium is a common manifestation in critically ill patients and is associated with worse clinical outcomes, we sought to characterize the reversibility of delirium after discontinuation of sedation and to determine whether... read more

Music as Therapy in the ICU

Music has been shown to reduce respiratory, cardiac and blood pressure frequencies in response to the reduction of stress hormones. In a randomized clinical trial, it was shown to reduce anxiety and sedation doses/intervals... read more

Recovery After Critical Illness: Putting the Puzzle Together

In this review, we seek to highlight how critical illness and critical care affect longer-term outcomes, to underline the contribution of ICU delirium to cognitive dysfunction several months after ICU discharge, to give new... read more

The Effects of Antibiotic Cycling and Mixing on Antibiotic Resistance in ICU

Whether antibiotic rotation strategies reduce prevalence of antibiotic-resistant, Gram-negative bacteria in intensive care units (ICUs) has not been accurately established. We aimed to assess whether cycling of antibiotics... read more

Long-term Recovery Following Critical Illness in an Australian Cohort

Almost all data on 5-year outcomes for critical care survivors come from North America and Europe. The aim of this study was to investigate long-term mortality, physical function, psychological outcomes and health-related... read more

Adjuvant Therapies in Critical Care: Music Therapy

Emerging from the perioperative and oncology fields, music therapy (MT) and patient-directed music interventions (PDMI) have recently garnered interest in the area of critical care. The main goal of these music-based adjuvant... read more

Receiving a Letter of Condolence After Loss of a Loved One in the ICU

This study describes the benefits of receiving a letter of condolence; mainly, it humanizes the medical institution (feeling of support, confirmation of the role played by the relative, supplemental information). However,... read more

Cerebral Autoregulation in the Prediction of Delayed Cerebral Ischemia and Clinical Outcome in Poor-Grade Aneurysmal Subarachnoid Hemorrhage Patients

High initial pressure reactivity index, presumably reflecting early brain injury, but not oxygen reactivity index, was associated with delayed cerebral ischemia and worse clinical outcome in poor-grade subarachnoid hemorrhage... read more