Successful Clearance of Persistent Staphylococcus Aureus Pneumonia Using High-dose Continuous Infusion Cefazolin

High-dose cefazolin (10 g daily), given as a continuous infusion (CI), was able to clear community-acquired methicillin-susceptible Staphylococcus aureus (MSSA) pneumonia while not exhibiting any signs of toxicity or adverse... read more

Cytomegalovirus Infection Adverse Impact on ICU Outcomes in COVID-19 Patients

In critically ill patients with SARS-CoV-2 pneumonia, cytomegalovirus (CMV) infection was frequently observed, and associated with increased ICU and hospital mortality. CMV co-infection correlated with a higher incidence... read more

Reducing Mortality in Critically Ill Patients

This book describes the techniques, strategies, and drugs that have been demonstrated by multicenter randomized trials to influence survival in critically ill patients, defined as those who have acute failure of at least... read more

Reducing Mortality in Critically Ill Patients

Adult Critical Care Medicine

This clinical casebook provides a comprehensive yet concise state-of-the-art review of adult critical care medicine. Presented in a case-based format, each case focuses on a scenario commonly encountered with an adult patient... read more

Adult Critical Care Medicine

Standard vs. Double Dosing of Beta-lactam Antibiotics in Critically Ill Sepsis Patients

The BULLSEYE trial is a randomized controlled study designed to enhance the treatment of critically ill patients with septic shock. The concept of administering higher and double doses of beta-lactams in such patients... read more

PCR and Biomarker Algorithms to Guide Antibiotics in Lower Respiratory Tract Infections

Acute chest syndrome (ACS) in sickle cell disease (SCD) is life-threatening and characterised by a new infiltrate on imaging plus fever or respiratory symptoms.1 Causes of ACS include infections, venous or fat embolisms or... read more

Eosinopenia as a Predictor of Clinical Outcomes in CAP Patients

Contrary to previously published data, our analysis did not demonstrate an association between eosinopenia and increased mortality risk in hospitalized patients with community-acquired pneumonia (CAP), highlighting the complexity... read more

Recent Advances in Severe Sepsis and Septic Shock Management

This review highlights recent advances in the treatment of severe sepsis and septic shock, emphasizing new strategies aimed at improving overall survival and reducing mortality in this patient population. Despite years... read more

Oral Health Care and VAP in ICU Patients

Both Zataria Multiflora (ZM) and Chlorhexidine (CHG) and CHG alone reduce ventilator-associated pneumonia (VAP) incidence and improve the oral health status of mechanically ventilated patients. However, the combination of... read more

Prone Position: Achieving Nutritional Goals

Critically ill patients in the prone position had longer hospital stays and higher mortality rates, while being more likely to initiate and remain on enteral nutrition for a longer period. However, no significant differences... read more

Cytokine Storm Syndrome

Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of... read more

Cytokine Storm Syndrome

Sepsis Management in Resource-limited Settings

This book is open access under a CC BY 4.0 license. It constitutes a unique source of knowledge and guidance for all healthcare workers who care for patients with sepsis and septic shock in resource-limited settings. More... read more

Sepsis Management in Resource-limited Settings

Thiamine and Ascorbic Acid in Sepsis and Septic Shock

Exploring the individual and synergistic effects of ascorbic acid and thiamine on key pathways implicated in sepsis pathophysiology has not yielded unequivocal evidence supporting their use without concomitant corticosteroids. Heterogeneity... read more

Severe Trauma and Sepsis: Organ Damage and Tissue Repair

This book discusses recent progress in organ damage and tissue repair following severe trauma and sepsis. In part 1, it introduces the theory and clinical practice in organ damage. In part 2, it covers all the subjects... read more

Severe Trauma and Sepsis: Organ Damage and Tissue Repair

ARDS Predictors in ICU Patients with Sepsis Using Dynamic Immune Indicator Changes

This study underscores the pivotal role of dynamic immune indicator changes in predicting acute respiratory distress syndrome (ARDS) development among ICU sepsis patients. By incorporating immune cell and immunoglobulin dynamics... read more

Alcohol Consumption Association with the Risk of Bacterial Infection and Pneumonia

Alcohol consumption has a nonlinear J-shaped dose–response association with the risk of acquiring and dying due to bacterial infection and pneumonia, where moderate consumption between one-half and four UK units per day... read more

Factors Influencing the Mortality of Patients with Subarachnoid Hemorrhage in the ICU

Spontaneous subarachnoid hemorrhage (SAH) is a prevalent condition for those between the ages of 50 and 60 years, with a high mortality rate in severe cases. The findings of this study indicate that a history of loss... read more

Epidemiology of Myocardial Injury in Trauma Patients

Pathological Troponin concentration elevation occurs in 7% of all trauma patients and it identifies the seriously injured high-risk cohort with worse outcomes than expected based on injury severity. The timing of the... read more

Fungal Infections Surveillance and Prevention in the NICU

It was determined that colonization and development of invasive mycoses among newborns are most often caused by Candida sp., while the detection of filamentous fungi remains sporadic. The etiological role of Malassezia... read more

Prognostic Predictor Using Lactate-to-Albumin Ratio in Patients with Cirrhosis and Sepsis

Lactate-to-albumin ratio (LAR) is strongly associated with poor prognosis in patients with cirrhosis and sepsis. LAR is a promising prognostic marker that provides clinicians with a simple and effective tool for risk... read more

ICU Protocols: A Step-wise Approach, Vol I

The second edition of this highly successful book includes up-to-date notes on the step-wise management of clinical emergencies encountered in everyday intensive care units (ICU). Each thoroughly revised chapter provides... read more

ICU Protocols: A Step-wise Approach, Vol I

Antibiotic Prophylaxis Effectiveness in Polytrauma Patients

The results indicate that antibiotic prophylaxis has no significant effect on mortality and clinical status compared with placebo or standard care in adult polytrauma patients but may reduce the risk of VAP. However,... read more