Tag: infection
A Novel Mechanism for COVID-19 Related Thrombotic Events: Platelet NO/ROS Equilibrium
The finding that platelet NO/ROS production imbalance contributes to the elevated risk of thrombotic events in COVID-19 has important clinical implications. Restoration of platelet NO production, as well as attenuation... read more
Inadequate Empirical Antibiotic Therapy in VAP: Risk Factors and Outcomes
Ventilator-associated pneumonia (VAP) caused by MDR pathogens were highly likely to receive inadequate empirical antibiotic therapy. The mortality rate and intubation duration were significantly longer in inadequately treated... read more
Red Book: Report of the Committee on Infectious Diseases
Extending an 8-decade tradition of excellence, Red Book® provides the most reliable and clinically useful information on the manifestations, etiology, epidemiology, diagnosis and treatment of more than 200 childhood infectious... read more
COVID-19 Handbook: Navigating the Future of Healthcare
The COVID-19 Handbook: Navigating the Future of Healthcare provides factual, evidence-based information on the coronavirus disease 2019 (COVID-19) pandemic. Presented in a concise PDF format, this valuable COVID-19 resource... read more
Holy Water Not so Holy: Potential Source of Elizabethkingia Pneumonia and Bacteremia in an Immunocompromised Host
This case report highlights that E. anophelis may indeed cause significant infection and should not be considered a contaminant especially in immunosuppressed individuals. The organism originates from water sources and may... read more
Ventilator-associated Pneumonia Pathogenesis: Old and New Mechanisms
Ventilator-associated pneumonia (VAP), defined as a lung infection that occurs in patients after 48 hours on mechanical ventilation, is among the most frequently found nosocomial infections in intensive care units around... read more
Aminoglycosides Impact on Survival Rate and Renal Outcomes in Patients with Urosepsis
The addition of aminoglycosides to beta-lactam therapy in critically ill patients with urosepsis did not significantly improve 30-day survival. Furthermore, aminoglycosides were not associated with worse renal outcomes.... read more
Femoral Head Osteonecrosis in Post-COVID-19 Patients
This study provides an insight into the relationship between COVID-19-related factors and the development of osteonecrosis of the femoral head (ONFH), emphasizing the critical role of cumulative steroid dose as the primary... read more
Clinical Characteristics and Survival Outcomes of Invasive Pulmonary Aspergillosis Patients
Invasive pulmonary aspergillosis (IPA) is a severe infectious disease caused by Aspergillus spp. It is associated with high mortality, particularly in immunocompromised patients, as well as in those with COVID-19 pneumonia... read more
Sepsis Management: PIRO and MODS
This book is unique in approaching multiple organ dysfunction syndrome (MODS) from the perspective of its pathophysiological mechanism, and addressing aspects that are overlooked in most of the available literature. Eminent... read more
Severe Adenoviral Infections: Disease Progression and Poor Prognostic Markers
Low hemoglobin, high serum ferritin, and high LDH in the second week are markers of disease progression and poor prognostic markers in severe adenoviral infections, emphasizing further research and targeted interventions. The... read more
VAP Recurrences Definition: European Experts Consensus
This consensus by European experts proposes four different ventilator-associated pneumonia (VAP) recurrence entities which should facilitate the harmonization of recurrence criteria for clinical practice and future studies. Thirty-six... read more
Septic Shock Metabolic Subgroups and Clinical Outcome
Three metabolic clusters exist in patients with septic shock with most metabolites differing between clusters and lipid species being most influential. Cluster proportions evolved over time with a high metabolite group... read more
Sepsis: Staging and Potential Future Therapies
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Variability in pathogenesis and complex pathophysiology often delay diagnosis and create significant challenges for clinical... read more
Infection Microbiology and Management
Infection: Microbiology and Management provides a core resource for the understanding of medical microbiology and infectious diseases. Content covers microbiological and clinical diagnosis, through to clinical management,... read more
Successful Clearance of Persistent Staphylococcus Aureus Pneumonia Using High-dose Continuous Infusion Cefazolin
High-dose cefazolin (10 g daily), given as a continuous infusion (CI), was able to clear community-acquired methicillin-susceptible Staphylococcus aureus (MSSA) pneumonia while not exhibiting any signs of toxicity or adverse... read more
Cytomegalovirus Infection Adverse Impact on ICU Outcomes in COVID-19 Patients
In critically ill patients with SARS-CoV-2 pneumonia, cytomegalovirus (CMV) infection was frequently observed, and associated with increased ICU and hospital mortality. CMV co-infection correlated with a higher incidence... read more
Reducing Mortality in Critically Ill Patients
This book describes the techniques, strategies, and drugs that have been demonstrated by multicenter randomized trials to influence survival in critically ill patients, defined as those who have acute failure of at least... read more
Adult Critical Care Medicine
This clinical casebook provides a comprehensive yet concise state-of-the-art review of adult critical care medicine. Presented in a case-based format, each case focuses on a scenario commonly encountered with an adult patient... read more
Standard vs. Double Dosing of Beta-lactam Antibiotics in Critically Ill Sepsis Patients
The BULLSEYE trial is a randomized controlled study designed to enhance the treatment of critically ill patients with septic shock. The concept of administering higher and double doses of beta-lactams in such patients... read more
PCR and Biomarker Algorithms to Guide Antibiotics in Lower Respiratory Tract Infections
Acute chest syndrome (ACS) in sickle cell disease (SCD) is life-threatening and characterised by a new infiltrate on imaging plus fever or respiratory symptoms.1 Causes of ACS include infections, venous or fat embolisms or... read more
Eosinopenia as a Predictor of Clinical Outcomes in CAP Patients
Contrary to previously published data, our analysis did not demonstrate an association between eosinopenia and increased mortality risk in hospitalized patients with community-acquired pneumonia (CAP), highlighting the complexity... read more
