Tag: infection
Moderna mRNA Vaccine Candidate’s Phase I Trial
Eight weeks to the day after press-releasing some top line results, the full paper is out on the Moderna mRNA vaccine candidate’s Phase I trial. I'm very glad to see it – it's going to be very important for the full data... read more
Research Shows Increased Thrombus Burden in COVID-19 Patients With STEMI
There may be a strong signal towards higher thrombus burden and poorer outcomes in COVID-19 patients presenting with STEMI, supporting the need for establishing COVID-19 status in all STEMI cases, according to a study published... read more
Heparin 2.0: A New Approach to the Infection Crisis
In April 2020, the US Food and Drug Administration granted emergency use authorization for certain medical devices to be used in patients with coronavirus disease 2019 (COVID-19). This included extracorporeal blood purification... read more
Approach to New Fever or Rigors in the ICU Patient
Failure to recognize neutropenic fever as a separate entity that requires immediate treatment. Routinely ordering urinalysis and sputum cultures (for most patients, this will only lead to false-positive results and unnecessary... read more
Elective Tracheostomy During COVID-19: To Whom, When, How?
We suggest to wait at least 14 days to perform tracheostomy. In patients with SOFA score > 6 and D dimer > 4, tracheostomy should not be performed or should be postponed. Optimized procedures and enhanced personal... read more
What We Should Learn From the First Wave of COVID-19
The pace at which the healthcare system has evolved in 2020 has been staggering. What system improvements we sustainably hold on to may be the most important factor in determining our community's future success. We may... read more
Incidence of Pulmonary Embolism in Non-critically ill COVID-19 Patients
Recent studies suggest that thrombotic complications are a common phenomenon in the novel SARS-CoV-2 infection. The main objective of our study is to assess cumulative incidence of pulmonary embolism (PE) in non critically... read more
Catheter-associated Urinary Tract Infection (CAUTI)
Urinalysis should not be checked simply due to cloudy or odorous urine (Class A recommendation from Infectious Diseases Society of America). This probably represents colonization of the Foley bag, not invasive infection. Be... read more
Increase in Rare Brain Inflammation and Stroke Linked to COVID-19
Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological and neuropsychiatric illness. Responding to this, a weekly virtual coronavirus... read more
High-Risk & Critical Care Obstetrics
Co-published with the Association of Women's Health, Obstetrics & Neonatal Nurses (AWHONN), this comprehensive book on advanced obstetrics practice focuses on the care of childbearing women with complications during pregnancy... read more
Why, When, and How to Use Lung Ultrasound During the COVID-19 Pandemic
The COVID-19 pandemic has further highlighted the usefulness of LUS in different clinical scenarios, underlining its advantages in terms of availability, operator- and patient-friendliness, relatively low cost and expertise... read more
High Risk of Thrombosis in Patients With Severe SARS-CoV-2 Infection
Despite anticoagulation, a high number of patients with ARDS secondary to COVID-19 developed life-threatening thrombotic complications. Higher anticoagulation targets than in usual critically ill patients should therefore... read more
Prophylaxis and Treatment of Venous Thromboembolic Disease in COVID-19
Patients with COVID-19 appear to be at elevated risk for thrombotic complications, including venous thromboembolism (VTE).1 In addition to traditional risk factors for VTE, indirect effects of the severity of illness as well... read more
Supporting the Shielded – Results from a National Survey of Shielding Doctors
In spring, NHS staff responded to the looming COVID-19 pandemic with an impressive level of strategic planning. As operating theatres closed and ICU beds were created, anaesthetists and intensivists faced new challenges on... read more
What is the Diagnostic Accuracy of Antibody Tests for the Detection of Infection with the COVID-19 Virus?
The sensitivity of antibody tests is too low in the first week since symptom onset to have a primary role for the diagnosis of COVID-19, but they may still have a role complementing other testing in individuals presenting... read more
The Case for Routine Screening for COVID-19 Before Surgery
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 5 million cases of coronavirus disease (COVID-19) worldwide and 345,000 deaths as of 25 May 2020. Based on accumulating international experience... read more
Perhaps something isn’t always better than nothing
It is not unreasonable to say the COVID-19 pandemic caught most of us by surprise. We did not know how infectious the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) virus leading to COVID-19 disease was, nor... read more
