Tag: infection
Link Between Diabetes and Hospital Readmission Rates
Patients with diabetes have higher rates of hospital readmission compared with patients without diabetes, according to a pilot study published in Clinical Diabetes and Endocrinology. In the first study, the readmission rate... read more
Growing Concerns of Hepatitis E in Europe
Cases of Hepatitis E in Europe have increased by 10x over 10 years, with 5617 cases in 2015. Testing, case definitions, diagnosis, and surveillance for HEV infection vary extensively across Europe, with only 20 member states... read more
Contact Precautions for Endemic MRSA and VRE
Physical barriers have been used to prevent infectious diseases dating back to leather gloves and coats used during the Black Death in medieval Europe. In the United States, isolation of persons with infections coincided... read more
Sepsis Prediction in Critically Ill Patients by Platelet Activation Markers on ICU Admission
Platelets have been involved in both immune surveillance and host defense against severe infection. To date, whether platelet phenotype or other hemostasis components could be associated with predisposition to sepsis in critical... read more
Optimal Timing of RRT in Patients with AKI in the Context of Sepsis
Among 620 patients enrolled in AKIKI, 494 (80%) had sepsis and 413 (67%) septic shock. This can help to suggest recommendations in septic patients with AKI. AKIKI showed no significant difference in mortality between early... read more
Recent Developments in Management of Critical Burn Injuries
Recent reports emphasize the dangers of over resuscitation in the setting of burn injury. No new medical therapy for inhalation injury has been generally adopted, but new standards for description of burn-related infections... read more
Sepsis-Associated 30-Day Risk-Standardized Readmissions
One third of sepsis survivors were readmitted and wide variation exists between hospitals. Several demographic and structural factors are associated with this variation. Measures of higher quality in-hospital care were correlated... read more
Rescue Strategy for Treating Severe Carbapenemase-Producing Klebsiella Pneumoniae Infections
Recent reports have suggested the efficacy of a double carbapenem (DC) combination, including ertapenem, for the treatment of carbapenem-resistant Klebsiella pneumoniae (CR-Kp) infections. We aimed to evaluate the clinical... read more
Evaluating Transfusion Strategies
Cancer patients are at increased risk of septic shock. Therefore, Bergamin et al set out to assess whether a restrictive strategy of red blood cell (RBC) transfusion reduces 28-day mortality when compared with a liberal strategy... read more
State Sepsis Mandates – A New Era for Regulation of Hospital Quality
New York State regulations mandating protocol-based sepsis care may have unintended consequences. Hospitals should have maximal flexibility in deciding how to implement protocol-guided care so that they can respond appropriately... read more
New Institute to Focus on Immune System
Vanderbilt University Medical Center (VUMC) is launching a new institute to coordinate initiatives among the rapidly evolving disciplines of infection biology, immunology and inflammatory diseases. The Vanderbilt Institute... read more
Evaluation of early antimicrobial therapy adaptation guided by the BetaLACTA test
Rapid diagnostic tests detecting microbial resistance are needed for limiting the duration of inappropriateness of empirical antimicrobial therapy (EAT) in ICU patients, besides reducing the use of broad-spectrum antibiotics.... read more
A Placebo-Controlled Trial of Antibiotics for Smaller Skin Abscesses
Uncomplicated skin abscesses are common, yet the appropriate management of the condition in the era of community-associated methicillin-resistant Staphylococcus aureus (MRSA) is unclear. As compared with incision and drainage... read more
WHO Resolution: Recognizing Sepsis as a Global Health Priority
The true burden of disease arising from sepsis remains unknown. The current estimates of 30 million episodes and 6 million deaths per year come from a systematic review that extrapolated from published national or local population... read more
Airway glucose homeostasis: a new target in the prevention and treatment of pulmonary infection
In health, the glucose concentration of airway surface liquid (ASL) is 0.4mM, around 12 times lower than blood glucose concentration. Airway glucose homeostasis is a set of processes that actively maintain low ASL glucose... read more
COPD can increase risk of developing sepsis
People with COPD have a higher than average risk of developing lung infections, such as pneumonia, which then puts them at higher risk for developing sepsis. Sepsis and septic shock can result from an infection anywhere in... read more
WHO tries to keep certain antibiotics largely off the table
In a bid to battle antibiotic resistance, the World Health Organization for the first time has classified antibiotics into three categories, including one that lists the drugs it hopes will not be used except in circumstances... read more
Diagnosis, Prevention, and Treatment of C. difficile: Current State of the Evidence
This is a summary of a systematic review that evaluated the recent evidence regarding the accuracy of diagnostic tests and the effectiveness of interventions for preventing and treating Clostridium difficile (C. difficile)... read more
ER Overcrowding Delays Sepsis Treatment
Prompt antibiotic initiation is associated with improved mortality in sepsis and septic shock. However, new research shows that patients with sepsis, a life-threatening complication of an infection, had delays approaching... read more
WHA Adopts Resolution on Sepsis
World Health Assembly and the World Health Organization made sepsis a global health priority, by adopting a resolution to improve, prevent, diagnose, and manage sepsis. This marks a quantum leap in the global fight against... read more
Addressing Sepsis – Video Recap of the WHA Side Event on Sepsis
On the occasion of the World Health Assembly passing a resolution on sepsis, the Global Sepsis Alliance, IAPO, and the German Federal Ministry of Health have hosted the "WHA Side Event on Sepsis" in Geneva on May... read more
Empirical MRSA Coverage for Nonpurulent Cellulitis
Cellulitis is an infection of the deep dermis and subcutaneous tissue, manifesting as expanding erythema, edema, and warmth of the skin. In most instances of cellulitis, the causative microorganism cannot be definitively... read more
