Tag: inflammation
Pleural Resident Macrophages and Pleural IRA B Cells Promote Immunity Against Pneumonia
Airway infection is a major cause of mortality worldwide. The identification of new mechanisms aiding in effective host immune response is therefore required. Here, we show that the specific depletion of the pleural immune... read more
tPA for Critically Ill ICU Patients with COVID-19: Does Alteplase Help?
How do you define a last-ditch effort to save someone's life from COVID-19? Perhaps giving tPA to a severe COVID patient? At this point, I am certain many of us have attempted, with informed consent of course, therapies for... read more
Thromboinflammation and Antithrombotics in COVID-19
Thrombotic complications of SARS-CoV-2 infection were recognized early in the pandemic, when infected patients often presented with abnormal coagulation findings and acute macrovascular obstruction, and evidence of pulmonary... read more
Vasopressor Choice and Timing in Vasodilatory Shock
Vasodilatory shock is the most common form of circulatory shock encountered in patients admitted to the intensive care unit (ICU). Sepsis is the predominant etiology, but other causes of vasodilatory shock include postoperative... read more
Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients
Plasma Biomarkers of systemic inflammation and endothelial activation are associated with ED delirium duration in older ED patients without dementia. A total of 156 patients were enrolled. IL-6 (POR = 1.59, 95%CI: 1.09–2.32)... read more
Obstructive Airway Diseases: Role of Lipid Mediators
Incidences of inflammatory airway diseases are on the rise across the world. Existing therapeutic options are ineffective, unsafe, and expensive, and severe cases are nonresponsive to conventional therapy. Therefore, it is... read more
Effect of Bradykinin Receptor Antagonism on ACE Inhibitor-associated Angioedema
This study compared the effect of placebo versus the bradykinin B2 receptor antagonist icatibant on symptoms of ACE inhibitor–associated angioedema in a mixed race population of patients. The study does not support the... read more
Inflammatory and Immunosuppressive Responses to COVID-19 and Bacterial Sepsis
Bacterial sepsis patients had early, severe inflammation, profound immune suppression, and life-threatening organ dysfunction that resolved over time; SARS-CoV-2 patients had less severe early inflammation and organ dysfunction... read more
Predicting Sepsis Severity at First Clinical Presentation
The severity and endotype signatures indicate that distinct immune signatures precede the onset of severe sepsis and lethality, providing a method to triage early sepsis patients. Gene expression signatures were obtained... read more
Critical COVID-19 Pneumonia Determinants
SARS-CoV-2 infection is benign in most individuals but, in approx. 10% of cases, it triggers hypoxemic COVID-19 pneumonia, which becomes critical in ˜3% of cases. The ensuing risk of death (˜1%) doubles every five years... read more
Postoperative Critical Care for Adult Cardiac Surgical Patients
This text reviews the postoperative management of patients who have undergone cardiac surgical procedures, some of the most common and most complicated forms of surgery. These patients and their management are characterized... read more
High-Dose Dexamethasone vs. Tocilizumab in COVID-19 Pneumonia
Our study findings discourage the use of high doses of dexamethasone in the management of moderate to severe COVID-19 ARDS. The routine use of such high doses to mitigate the inflammatory cytokine storm in these patients... read more
Immunological Dysfunction Persists for 8 months Following Initial Mild-to-Moderate COVID-19 Infection
A proportion of patients surviving acute coronavirus disease 2019 (COVID-19) infection develop post-acute COVID syndrome (long COVID (LC)) lasting longer than 12 weeks. Here, we studied individuals with LC compared to... read more
Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 Pneumonia
The research will be retrospective, and will include a review of medical history of all patients admitted in the COVID-19 ICU of the University hospital Osijek during 2020 and 2021. Associated comorbidity, hospital admission... read more
MIF But Not MIF-2 Recruits Inflammatory Macrophages in an Experimental Polymicrobial Sepsis Model
Excessive inflammation drives the progression from sepsis to septic shock. Macrophage migration inhibitory factor (MIF) is of interest because MIF promoter polymorphisms predict mortality in different infections, and anti-MIF... read more
Biomarker-guided Steroid Dosing in COVID-19 Pneumonia
Although corticosteroid administration has been associated with improved outcomes in severe COVID-19 pneumonia, their ideal use remains undefined with a "one size fits all" approach used, irrespective of the individual inflammatory... read more
Obesity, Inflammatory and Thrombotic Markers, and Major Clinical Outcomes in Critically Ill Patients with COVID-19 in the US
In critically ill patients with COVID-19, higher BMI was not associated with death or thrombotic events but was associated with a greater risk of ARDS and AKI-RRT. The lack of an association between BMI and circulating... read more
A Rare of Case of COVID-19-Related Pericardial Effusion and Cardiac Tamponade
Acute pericarditis involves inflammation of the pericardial sac, which is made of an inner mesothelial visceral layer that surrounds the heart. Normally, this layer produces ~50 mL of fluid to lubricate the heart and... read more
miR-221-5p-Mediated Downregulation of JNK2 Aggravates ALI
Sepsis and acute lung injury (ALI) are linked to mitochondrial dysfunction; however, the underlying mechanism remains elusive. We previously reported that c-Jun N-terminal protein kinase 2 (JNK2) promotes stress-induced mitophagy... read more
The Relationship Between Vitamin D and Asthma Exacerbation
Asthma is a chronic airway inflammatory condition that affects millions of people worldwide. It presents with reversible bronchoconstriction that makes it difficult for patients to breathe. Asthma flare-ups have several triggers,... read more
WHO Issues Guidelines on the Treatment of Children with MIS Associated with COVID-19
WHO issued updated guidelines on the management of multisystem inflammatory syndrome (MIS) in children associated with COVID-19 (MIS-C). MIS-C is a rare but serious condition where children with COVID-19 develop inflammation... read more
Mortality and Clinical Characteristics of MIS-C Associated with COVID-19
The clinical presentation and severity of Multisystem Inflammatory Syndrome in Children associated with COVID-19 (MIS-C) is widespread and presents a very low mortality rate in high-income countries. This research describes... read more
