Influenza: The Hundred-Year Hunt to Cure the Deadliest Disease in History

A veteran ER doctor explores the troubling, terrifying, and complex history and present-day research of the flu virus, from the origins of the Great Flu that killed millions, to vexing questions such as: are we prepared for... read more

Influenza: The Hundred-Year Hunt to Cure the Deadliest Disease in History

Impact of Early Neuraminidase Inhibitor Treatment on Clinical Outcomes in Patients with Influenza B-related Pneumonia

The aim of this study is to evaluate the impact of early (within 2 days after disease onset) neuraminidase inhibitor (NAI) administration on clinical outcomes in patients with laboratory-confirmed influenza B-related pneumonia... read more

Impact of Early Neuraminidase Inhibitor Treatment on Clinical Outcomes in Patients with Influenza B-related Pneumonia

Care for Critically Ill Patients with COVID-19

Initial reports suggest that COVID-19 is associated with severe disease that requires intensive care in approximately 5% of proven infections. Given how common the disease is becoming, as in prior major severe acute respiratory... read more

Care for Critically Ill Patients with COVID-19

Flu: The Story of the Great Influenza Pandemic of 1918 and the Search for the Virus That Caused It

The fascinating, true story of the world's deadliest disease. In 1918, the Great Flu Epidemic felled the young and healthy virtually overnight. An estimated forty million people died as the epidemic raged. Children... read more

Flu: The Story of the Great Influenza Pandemic of 1918 and the Search for the Virus That Caused It

Severe Influenza in Critically Ill Patients

The present review summarizes current knowledge on pathogenesis and clinical manifestations of severe influenza. Immunological dysfunction during viral infection correlates with severity and mortality among ICU patients.... read more

Severe Influenza in Critically Ill Patients

The Great Influenza: The Story of the Deadliest Pandemic in History

The story of the deadliest pandemic in history, a study of the 1918 pandemic, the year’s outstanding book on science or medicine. John M. Barry has had considerable influence on both pandemic policy and flood protection.... read more

The Great Influenza: The Story of the Deadliest Pandemic in History

ECMO Support in Coronavirus Disease 2019 (COVID-19)

Extracorporeal membrane oxygenation (ECMO) use has been increasing in severe respiratory and/or cardiac failure despite implementation of conventional care. This technology has been proven valuable in treating viral pneumonia... read more

ECMO Support in Coronavirus Disease 2019 (COVID-19)

How to Save Lives in a COVID-19 Pandemic

The pace of COVID-19, the ongoing novel coronavirus outbreak, has been astonishing, and it is inevitable that this will become a pandemic, if it hasn't already. When a disease is a pandemic, it considered to be an ongoing... read more

How to Save Lives in a COVID-19 Pandemic

Coronavirus Can Spread Between Humans

The leader of a Chinese government team of experts announced Monday that human-to-human transmission of a new coronavirus has been confirmed. The finding could raise fears that the infection might not require contact with... read more

Coronavirus Can Spread Between Humans

Corticosteroids as Adjunctive Therapy in the Treatment of Influenza

Corticosteroid treatment in influenza is associated with increased mortality and hospital-acquired infection, but the evidence relates mainly to high corticosteroid doses and is of low quality with potential confounding by... read more

Corticosteroids as Adjunctive Therapy in the Treatment of Influenza

Get Well Soon: History’s Worst Plagues and the Heroes Who Fought Them

A witty, irreverent tour of history's worst plagues―from the Antonine Plague, to leprosy, to polio―and a celebration of the heroes who fought them. In 1518, in a small town in Alsace, Frau Troffea began dancing and... read more

Get Well Soon: History’s Worst Plagues and the Heroes Who Fought Them

Flu Has Sickened More Than 13 Million This Season

The CDC estimates that there have been 13.2 million to 15.2 million flu illnesses this season. The CDC estimates there have been 6.2 million to 7.2 million flu medical visits and 155,000 to 186,000 flu hospitalizations this... read more

Flu Has Sickened More Than 13 Million This Season

Corticosteroid Treatment in Critically Ill Patients with Severe Influenza Pneumonia

Administration of corticosteroids in patients with severe influenza pneumonia is associated with increased ICU mortality, and these agents should not be used as co‑adjuvant therapy. A total of 1846 patients with primary... read more

Corticosteroid Treatment in Critically Ill Patients with Severe Influenza Pneumonia

Effectiveness of Influenza Vaccination on Hospitalizations and Risk Factors for Severe Outcomes in Hospitalized Patients With COPD

Influenza vaccination significantly reduced influenza-related hospitalization among patients with Chronic Obstructive Pulmonary Disease (COPD). Initiatives to increase vaccination uptake and early use of antiviral agents... read more

Effectiveness of Influenza Vaccination on Hospitalizations and Risk Factors for Severe Outcomes in Hospitalized Patients With COPD

Guidelines for the Diagnosis and Management of CIRCI in Critically Ill Patients

This part II of the guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients is related to acute illnesses that may be complicated by CIRCI. We... read more

Guidelines for the Diagnosis and Management of CIRCI in Critically Ill Patients

Single-Center Experience With Venovenous ECMO for Influenza-Related ARDS

Influenza-related ARDS has a high mortality rate and patients treated only with mechanical ventilation have worse outcome than those managed with VV ECMO. More liberal use of ECMO should be considered in patients with influenza-related... read more

Single-Center Experience With Venovenous ECMO for Influenza-Related ARDS

Pandemics Cross Borders: How to Tackle Them From a Global Perspective

Steve A. Webb, MD, gives a plenary talk at the 47th Critical Care Congress, “Pandemics Cross Borders: How to Tackle Them From a Global Perspective.”... read more

Pandemics Cross Borders: How to Tackle Them From a Global Perspective

Critical Care Pharmacists and Medication Management in an ICU Recovery Center

Many patients experience complications following critical illness; these are now widely referred to as post-intensive care syndrome (PICS). An interprofessional intensive care unit (ICU) recovery center (ICU-RC), also known... read more

Critical Care Pharmacists and Medication Management in an ICU Recovery Center