Trends in Time to Extubation for Pediatric Postoperative Cardiac Patients

In this large, multicenter database study, early extubation rates in postoperative cardiac patients did not significantly change between 2009 and 2018. Centers that performed early extubation more frequently did not have... read more

High Flow Nasal Cannula: Physiological Effects and Clinical Applications

This book presents the state of the art in high-flow nasal cannula (HFNC), an oxygen therapy technique that has recently proven to be a very promising approach to supporting respiratory function in several medical fields. In... read more

High Flow Nasal Cannula: Physiological Effects and Clinical Applications

Nasal High-Flow Therapy during Neonatal Endotracheal Intubation

Among infants undergoing endotracheal intubation at two Australian tertiary neonatal intensive care units, nasal high-flow therapy during the procedure improved the likelihood of successful intubation on the first attempt... read more

Closed-loop oxygen control improves oxygen therapy in AHRF patients under high flow nasal oxygen

Closed-loop oxygen control improves oxygen administration in patients with moderate-to-severe AHRF treated with HFNO, increasing the percentage of time in the optimal oxygenation range and decreasing the workload of healthcare... read more

Critically Unwell Child Intubation in the ED

Intubation in the pediatric emergency department is scary stuff. For critically ill children who require intubation, it is rarely practiced outside of the critical care unit. With the centralization of services there are... read more

Why Are We Still Talking about ICP and Ketamine?

A trauma patient required emergent intubation during a recent shift. The altered patient was suspected of having an intracranial bleed. My resident was concerned about rapid onset of hypoxia and other internal injuries causing... read more

Optimal Respiratory Support for COVID-19 Patients

Noninvasive respiratory support is an essential component of critical care. Both noninvasive ventilation, with its different interface types and modes (including helmet and face masks), and high-flow nasal oxygen (HFNO) are... read more

Postintubation Sedation Administration in the Pediatric ED

Most pediatric patients do not receive PIS within an adequate time frame. Patients who receive long-acting paralytic agents are much less likely to be adequately sedated after rapid sequence intubation (RSI) compared with... read more

Estimated and Measured Post-tetanic Count Effect

Comparison of two pharmacokinetic–pharmacodynamic models of rocuronium bromide during profound neuromuscular block. Our findings indicate that using plasma concentrations of rocuronium bromide estimated with either of... read more

Physiologically Difficult Airway Evaluation

Multiple international airway societies have created guidelines for the management of the difficult airway. In critically ill patients, there are physiologic derangements beyond inadequate airway protection or hypoxemia.... read more

Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions

Weaning protocols for discontinuation of invasive mechanical ventilation often mandate resolution of shock. Whether extubation while receiving vasopressors is associated with harm is uncertain. To examine whether extubation... read more

Treating Hypoxia in Discharged COVID-19 Patients

The ICU technique of placing a hypoxic patient in a prone position is being widely used to care for COVID-19 patients in respiratory distress to improve oxygenation and possibly to avoid intubation. The COVID-19 pandemic... read more

Noninvasive Respiratory Support for COVID-19 Patients: When, for Whom, and How?

The significant mortality rate and prolonged ventilator days associated with invasive mechanical ventilation (IMV) in patients with severe COVID-19 have incited a debate surrounding the use of noninvasive respiratory support... read more

Transtracheal Jet Ventilation in the Can’t Intubate Can’t Oxygenate Emergency

Transtracheal jet ventilation (TTJV) is associated with a high risk of device failure and barotrauma in the CICO emergency. Guidelines and recommendations supporting the use of TTJV in CICO should be reconsidered. 44 studies... read more

Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 Pneumonia

The research will be retrospective, and will include a review of medical history of all patients admitted in the COVID-19 ICU of the University hospital Osijek during 2020 and 2021. Associated comorbidity, hospital admission... read more

Effect of High-Flow Oxygen Therapy vs Conventional Oxygen Therapy on Invasive Mechanical Ventilation and Clinical Recovery in Patients With Severe COVID-19

An overall good trial that supports the use of high flow oxygen therapy in patients with Severe COVID-19. Randomized controlled trial conducted across three centers in Columbia over 5 months from August 2020 to January... read more

Ventilator Modes Made Easy: An Easy Reference for RRT’s, RN’s, and Medical Residents

Who says understanding ventilator modes has to be hard? This book gives you easy to understand information that every RRT, RN, or Resident always wishes they had. Each mode is described in simple language and answers the... read more

Ventilator Modes Made Easy: An Easy Reference for RRT’s, RN’s, and Medical Residents

Respiratory Drive in Sepsis and Septic Shock Patients: Modulation by High-flow Nasal Cannula

Patients with sepsis and septic shock of extrapulmonary origin present elevated respiratory drive and effort, which can be effectively reduced by high-flow nasal cannula. 25 nonintubated patients with extrapulmonary sepsis... read more

Mechanical Ventilation Promotes Lung Tumor Spread by Modulation of Cholesterol Cell Content

Mechanical stretch of cancer cells can alter their invasiveness. During mechanical ventilation, lungs may be exposed to an increased amount of stretch, but the consequences on lung tumors have not been explored. To characterize... read more

Safe Tracheal Extubation After General Anesthesia

Tracheal extubation generates less interest than tracheal intubation. Research, guidelines and clinical anecdotes tend to focus on airway management at the beginning of anesthesia, and it is rare for the challenges of extubation... read more

Intubation Practice and Outcomes Among Pediatric Emergency Departments

While tracheal intubation (TI) characteristics vary between pediatric Emergency Departments and ICUs, outcomes are similar. Shock and limited mouth opening were independently associated with adverse TI events in the Emergency... read more

Etomidate vs. Ketamine for Emergency Endotracheal Intubation

While the primary outcome of Day 7 survival was greater in patients randomized to ketamine, there was no significant difference in survival by Day 28. A prospective, randomized, open-label, parallel assignment, single-center... read more