Effect on Norepinephrine Administration Timing on Prognosis of Septic Shock Patients

Norepinephrine initiation ≤1 h is associated with lower 28-day mortality in patients with septic shock. Early norepinephrine administration is also associated with a shorter time to achieve MAP ≥65 mmHg, lower 24-h intravenous... read more

Early Tracheostomy in Ventilated COVID-19 Patients Reduces VAP Incidence

Tracheostomy can reduce mechanical ventilation (MV) duration, ICU and hospital length of stay (LOS), and ventilator-associated pneumonia (VAP) risk in critically ill patients. The timing of tracheostomy in COVID-19 patients... read more

Impacts of Initial ICU Driving Pressure on Outcomes in Acute Hypoxemic Respiratory Failure

Driving pressure (DP) is a marker of severity of lung injury in patients with acute respiratory distress syndrome (ARDS) and has a strong association with outcome. However, it is uncertain whether limiting DP can reduce... read more

Implementing a Bedside Percutaneous Tracheostomy and Ultrasound Gastrostomy Team Reduces Length of Stay and Hospital Costs

Thousands of critically ill patients every year in the United States receive tracheostomy and gastrostomy procedures. Recent research has investigated the benefits of a combined team approach to these procedures, with associated... read more

Tele-ICU Rounds Ineffective in Shortening ICU Stay for Patients

Daily multidisciplinary rounds conducted by a board-certified intensivist through telemedicine do not reduce intensive care unit (ICU) length of stay (LOS) in critically ill adult patients, according to a study published... read more

Hyperoxemia in Acute Trauma is Common and Associated with a Longer Hospital Stay

This study indicate that hyperoxemia is not associated with increased 28-day mortality compared to normoxemia. Nonetheless, both moderate and severe hyperoxemia are frequently detected in trauma patients, with severe hyperoxemia... read more

The Hidden Value of MRI: Modifying Treatment Decisions in C-spine Injuries

This study provides a critical evaluation of the implications of additional magnetic resonance imaging (MRI) use in the diagnosis of c-spine injuries. We have demonstrated that an adjunctive MRI extends patients' ED stays,... read more

Early Ketamine Sedation Outcomes Among Mechanically Ventilated COVID-19 Patients

In a diverse sample of U.S. hospitals, about one in 30 patients mechanically ventilated with COVID-19 received ketamine infusions. Early ketamine may have an association with higher hospital mortality, increased total cost,... read more

Impact of a Rounding Checklist Implementation in the Trauma ICU on Clinical Outcomes

Impact of a Rounding Checklist Implementation in the Trauma ICU on Clinical Outcomes

We aimed to evaluate the effectiveness of an intensive care unit (ICU) round checklist, FAST HUGS BID (Feeding, Analgesia, Sedation, Thromboembolic prophylaxis, Head-of-bed elevation, Ulcer prophylaxis, Glycemic control,... read more

The impact of physical medicine and rehabilitation consultation on clinical outcomes in the SICU

The impact of physical medicine and rehabilitation consultation on clinical outcomes in the SICU

The impact of a physical medicine and rehabilitation (PM&R) consultation on clinical outcomes in critically ill surgical patients remains unclear. The aim of this study is to examine whether the patients who received PM&R... read more

Prophylactic Melatonin for Delirium in Intensive Care (Pro-MEDIC)

Prophylactic Melatonin for Delirium in Intensive Care (Pro-MEDIC)

Enteral melatonin initiated within 48 h of ICU admission did not reduce the prevalence of delirium compared to placebo. These findings do not support the routine early use of melatonin in the critically ill. A total of... read more

Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions

Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions

Weaning protocols for discontinuation of invasive mechanical ventilation often mandate resolution of shock. Whether extubation while receiving vasopressors is associated with harm is uncertain. To examine whether extubation... read more

Oral Midodrine Feasibility in Early Sepsis

Oral Midodrine Feasibility in Early Sepsis

This study proved the feasibility of clinical trial to use oral midodrine in early sepsis. The study was not powered to detect statistically significant differences between the two groups, and therefore, the results from... read more

Effect of a Single High Dose of Vitamin D3 on Hospital LOS in Patients with COVID-19

Effect of a Single High Dose of Vitamin D3 on Hospital LOS in Patients with COVID-19

Among hospitalized patients with COVID-19, a single high dose of vitamin D3, compared with placebo, did not significantly reduce hospital length of stay. The findings do not support the use of a high dose of vitamin D3 for... read more

Nutritional Risk Screening and Body Composition in COVID-19 Patients

Nutritional Risk Screening and Body Composition in COVID-19 Patients

Present findings confirm the clinical utility of NRS-2002 to assess nutritional risk in patients with COVID-19 at hospital admission and in predicting LOS, and that bioimpedance does not seem to add further predictive value.... read more

Prior Routine Use of NSAIDs and Important Outcomes in Hospitalised COVID-19 Patients

Prior Routine Use of NSAIDs and Important Outcomes in Hospitalised COVID-19 Patients

Coronavirus disease 2019 (COVID-19) infection causes acute lung injury, resulting from aggressive inflammation initiated by viral replication. There has been much speculation about the potential role of non-steroidal inflammatory... read more

Quetiapine Decreases Mortality and Improve Neurological Outcomes in Critically-ill TBI Patients

Quetiapine Decreases Mortality and Improve Neurological Outcomes in Critically-ill TBI Patients

Quetiapine may decrease mortality and improve neurological outcomes in critically-ill traumatic brain injury (TBI) patients. It has a dose-dependent effect to decrease intracranial pressure (ICP) and increase cerebral perfusion... read more