Early Mobilization Reduces Duration of Mechanical Ventilation and Intensive Care Unit Stay in Patients With ARF

The introduction of early mobilization for patients with mechanical ventilation (MV) in the ICU shortened MV durations and ICU stays. A multidisciplinary team that includes the patient's family can work together to improve... read more

Early Mobilization Reduces Duration of Mechanical Ventilation and Intensive Care Unit Stay in Patients With ARF

Beyond Ventilator-induced Diaphragm Dysfunction

Respiratory muscles are essential to ensure the vital function of breathing. The diaphragm is a unique respiratory muscle, because it contracts throughout the individual's life span without resting, not even during sleep.... read more

Beyond Ventilator-induced Diaphragm Dysfunction

Reversing Neuromuscular Blockade

Neuromuscular blocking drugs have for years enabled anesthesiologists beneficially to relax skeletal muscles to improve anesthetic management, increase safety and quality of tracheal intubation, and to provide favorable intraoperative... read more

Reversing Neuromuscular Blockade

Impact of Vasoactive Medications on ICU-Acquired Weakness in Mechanically Ventilated Patients

In mechanically ventilated patients enrolled in a randomized clinical trial of early mobilization, the use of vasoactive medications was independently associated with the development of ICU-acquired weakness. Prospective... read more

Impact of Vasoactive Medications on ICU-Acquired Weakness in Mechanically Ventilated Patients

Evaluating Delivery of Low Tidal Volume Ventilation in Six ICUs Using Electronic Health Record Data

Despite low mean tidal volume in the cohort, a significant percentage of patients were exposed to a prolonged duration of high tidal volumes which was correlated with higher mortality. Detailed ventilator records in the... read more

Evaluating Delivery of Low Tidal Volume Ventilation in Six ICUs Using Electronic Health Record Data

Effect of a Sepsis Educational Intervention on Hospital Stay

Adherence to a bundle strategy is low following an educational intervention. However, when patients are managed after instruction in guideline recommendations, hospital stay may be significantly reduced. The main cause... read more

Effect of a Sepsis Educational Intervention on Hospital Stay

Mechanical Ventilation Sedation Necessary for Comfort According to Nurses

Nurses' attitudes toward sedating patients receiving mechanical ventilation have shifted in the past decade, with fewer nurses now believing that all patients should be sedated. However, more than half of nurses still agree... read more

Mechanical Ventilation Sedation Necessary for Comfort According to Nurses

Laryngeal Injury and Upper Airway Symptoms After Oral Endotracheal Intubation With Mechanical Ventilation During Critical Care

Laryngeal injury from intubation is common in the ICU setting. Guidelines for laryngeal assessment and postextubation surveillance do not exist. A systematic approach to more robust investigations could increase knowledge... read more

Laryngeal Injury and Upper Airway Symptoms After Oral Endotracheal Intubation With Mechanical Ventilation During Critical Care

Estimated Effects of Early Diuretic Use in Critical Illness

The main objectives of this study was to estimate the effects of diuretic use during the first 24 hours of an ICU stay on in-hospital mortality and other clinical outcomes including acute kidney injury (AKI) and duration... read more

Estimated Effects of Early Diuretic Use in Critical Illness

Extubating Ventilated Patients on Vasoactive Infusions is Safe

In a large single centre study, 21% of intubated patients who received infusions of vasoactive infusions while mechanically ventilated were extubated for the first time while still receiving them. Coincident with their earlier... read more

Extubating Ventilated Patients on Vasoactive Infusions is Safe

Safety and Efficacy of VBF in Critically Ill, Mechanically Ventilated Adults Using the PERFECT Protocol

Underfeeding in critical illness is common and associated with poor outcomes. According to large prospective hospital studies, volume-based feeding (VBF) safely and effectively improves energy and protein delivery to critically... read more

Safety and Efficacy of VBF in Critically Ill, Mechanically Ventilated Adults Using the PERFECT Protocol

Sepsis Surveillance Using Adult Sepsis Events Simplified eSOFA Criteria Versus Sepsis-3 Sequential Organ Failure Assessment Criteria

Sepsis-3 defines organ dysfunction as an increase in the Sequential Organ Failure Assessment score by greater than or equal to 2 points. However, some Sequential Organ Failure Assessment score components are not routinely... read more

Sepsis Surveillance Using Adult Sepsis Events Simplified eSOFA Criteria Versus Sepsis-3 Sequential Organ Failure Assessment Criteria

Does high PEEP prevent alveolar cycling?

Acute respiratory distress syndrome (ARDS) patients need mechanical ventilation to sustain gas exchange. Animal experiments showed that mechanical ventilation with high volume/plateau pressure and no positive end-expiratory... read more

Does high PEEP prevent alveolar cycling?

Inter-Rater Reliability Between PICU Nurses Performing a Modification to the Glasgow Coma Scale

The objective of this study was to estimate the inter-rater reliability of critical care nurses performing a pediatric modification of the Glasgow Coma Scale in a contemporary pediatric intensive care unit (PICU). All... read more

Inter-Rater Reliability Between PICU Nurses Performing a Modification to the Glasgow Coma Scale

Management of Cardiogenic Shock

Cardiogenic shock (CS) remains the most common cause of death in patients with acute myocardial infarction although mortality could be reduced from formerly ∼80% to 40–50%. In addition to percutaneous coronary intervention... read more

Management of Cardiogenic Shock

A Core Outcome Set for Critical Care Ventilation Trials

The main objective for this study was to obtain international consensus on a set of core outcome measures that should be recorded in all clinical trials of interventions intended to modify the duration of ventilation for... read more

A Core Outcome Set for Critical Care Ventilation Trials

Essentials of Mechanical Ventilation

The acclaimed application-based guide to adult mechanical ventilation, updated to reflect the latest topics and practice guidelines. This practical guide is written from the perspective of authors who have nearly 100 years'... read more

Essentials of Mechanical Ventilation

How Best to Set the Ventilator on Extracorporeal Membrane Lung Oxygenation

Mechanical ventilation and extracorporeal support are marginally integrated. The best environment for lung healing – complete lung collapse or protective ventilation strategy or fully open and immobile lung (all three conditions... read more

How Best to Set the Ventilator on Extracorporeal Membrane Lung Oxygenation

Core Outcome Measures for Critical Care Ventilation Trials

The main objective for this study was to obtain international consensus on a set of core outcome measures that should be recorded in all clinical trials of interventions intended to modify the duration of ventilation for... read more

Core Outcome Measures for Critical Care Ventilation Trials

Emergency Department Hyperoxia Associated with Increased Mortality in Mechanically Ventilated Patients

Emergency Department exposure to hyperoxia is common and associated with increased mortality in mechanically ventilated patients achieving normoxia after admission. This suggests that hyperoxia in the immediate post-intubation... read more

Emergency Department Hyperoxia Associated with Increased Mortality in Mechanically Ventilated Patients

Effect of an ICU Diary on PTSD Symptoms Among Patients Receiving Mechanical Ventilation

Keeping a diary for patients while they are in the intensive care unit (ICU) might reduce their posttraumatic stress disorder (PTSD) symptoms. Among 657 patients who were randomized completed the trial. At 3 months, significant... read more

Effect of an ICU Diary on PTSD Symptoms Among Patients Receiving Mechanical Ventilation