Impact of extended lung protection during mechanical ventilation on lung recovery in patients with COVID-19 ARDS

The extended lung protection with strict control of ΔP for moderate to severe ARDS plus deranged mechanics is feasible and could be implemented in this pilot study with some beneficial impact on the recovery of lung function.... read more

Weaning From Mechanical Ventilation in ICUs Across 50 Countries

Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients... read more

Early In-Bed Cycle Ergometry in Mechanically Ventilated Patients

Among adults receiving mechanical ventilation in the ICU, adding early in-bed Cycling to usual physiotherapy did not improve physical function at 3 days after discharge from the ICU compared with Usual physiotherapy alone.... read more

Mechanical Ventilation in the ICU: A New Approach and Treatment

Mechanical Ventilation in the ICU: A New Approach and Treatment

In the present book, a broad description of the processes carried out in patients with mechanical ventilation in the ICU is made. It covers from an overview of mechanical ventilation and some of its history to the processes... read more

Early Ketamine Sedation Outcomes Among Mechanically Ventilated COVID-19 Patients

In a diverse sample of U.S. hospitals, about one in 30 patients mechanically ventilated with COVID-19 received ketamine infusions. Early ketamine may have an association with higher hospital mortality, increased total cost,... read more

The role of pleural pressure and airway closure during mechanical ventilation

The role of pleural pressure and airway closure during mechanical ventilation

Related to our paper, Van Egmond et al. highlighted key physiological concepts we must be aware of. We believe, however, that the described physiological com-plexity has limited impact on the daily use of esophageal pressure... read more

Immunosuppression Not Associated with a Higher Incidence of ICU-acquired Bacterial Bloodstream Infections

Immunosuppression Not Associated with a Higher Incidence of ICU-acquired Bacterial Bloodstream Infections

In this monocentric, retrospective observational cohort study, the incidence of ICU-acquired bacterial BSI was not different between immunocompromised and non-immunocompromised patients. This suggests that the clinical... read more

Two weaning strategies for NIV in COPD patients with ARF

Two weaning strategies for NIV in COPD patients with ARF

Non-Invasive Ventilation (NIV) is a crucial therapy for managing acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD) with hypercapnic respiratory failure. Research has shown that NIV can decrease the rate... read more

Tezepelumab in a case of severe asthma exacerbation and influenza-pneumonia on VV-ECMO

Tezepelumab in a case of severe asthma exacerbation and influenza-pneumonia on VV-ECMO

We present a case of 43-year-old male patient with broadly by Omalizumab, Mepolizumab and Benralizumab pretreated allergic asthma, who suffered a near fatal exacerbation, triggered by an influenza A infection. Due to... read more

Prone Positioning During ECMO for Severe ARDS

Prone Positioning During ECMO for Severe ARDS

The ongoing debate on optimal extracorporeal membrane oxygenation (ECMO) care emphasizes the need for rigorous investigation, acknowledging the value of observational data in routine The PRONECMO study, with its pragmatic... read more

Chest Computed Tomography Severity Score at ICU Admission and Respiratory Outcomes

Chest Computed Tomography Severity Score at ICU Admission and Respiratory Outcomes

COVID-19 patients with >50% lung involvement on Chest-CT admission presented higher chances to stay longer on invasive mechanical ventilation and more chances to developed ventilator-associated pneumonia. 121 patients... read more

Sepsis Mortality Among ICU Patients with Hematological Malignancy

Sepsis Mortality Among ICU Patients with Hematological Malignancy

Over the past two decades, there have been substantial improvements in mortality in hematological malignancy patients with sepsis, including across all levels of illness severity and in patients requiring mechanical ventilation.... read more

Textbook of Ventilation, Fluids, Electrolytes and Blood Gases

Textbook of Ventilation, Fluids, Electrolytes and Blood Gases

The Textbook of Ventilation, Fluids, Electrolytes and Blood Gases encompass essential topics for which thorough education and training is a must for any clinician who manages these patients. This book has four sections, each... read more

Clinical Outcomes in Critically Ill COVID-19 Unvaccinated Patients Admitted to the ICU

Clinical Outcomes in Critically Ill COVID-19 Unvaccinated Patients Admitted to the ICU

We analyzed unvaccinated critically ill ICU patients with COVID-19 and interpreted their demographics, clinical characteristics, comorbidities, and laboratory data upon ICU admission for a better understanding of their impact... read more

Dyspnea and Dyspnea-Associated Anxiety in ICU Patients

Dyspnea and Dyspnea-Associated Anxiety in ICU Patients

Dyspnea is frequently associated with anxiety, prolonged days on mechanical ventilation, and worse quality of life after discharge. It can also increase the risk of posttraumatic stress disorder post ICU discharge. However,... read more

Heat Shock Protein 27 in COVID-19 and non-COVID ARDS Pathogenesis

Heat Shock Protein 27 in COVID-19 and non-COVID ARDS Pathogenesis

Acute respiratory distress syndrome (ARDS) is a common cause of hypoxemic respiratory failure in intensive care units that has increased dramatically as a result of the COVID-19 pandemic. In both COVID-19 and non-COVID... read more

Efficacy of High-Flow Nasal Cannula Oxygen Therapy in Patients with AHRF

Efficacy of High-Flow Nasal Cannula Oxygen Therapy in Patients with AHRF

This study suggests that high-flow nasal cannula (HFNC) therapy in general respiratory wards may be a potential rescue therapy for patients with respiratory failure. Electrical impedance tomography (EIT) potentially monitors... read more