Secondary Bacterial Pneumonia is the Key Factor in COVID-19 Fatalities Not Cytokine Storm

Secondary Bacterial Pneumonia is the Key Factor in COVID-19 Fatalities Not Cytokine Storm

A recent study found that secondary bacterial pneumonia, rather than the much-discussed “cytokine storm,” is a significant factor in COVID-19-related fatalities. Almost half of the patients who required mechanical... read more

Prone vs. Supine Position Ventilation in Intubated COVID-19 Patients

Prone vs. Supine Position Ventilation in Intubated COVID-19 Patients

Whether prone positioning of patients undergoing mechanical ventilation for COVID-19 pneumonia has benefits over supine positioning is not clear. We conducted a systematic review with meta-analysis to determine whether prone... read more

Significant Persistent Pain Symptoms After Critical Care Illness

Significant Persistent Pain Symptoms After Critical Care Illness

Persistent pain could be a common health problem after critical illness care. Our data also suggest that there is a lack of specific follow-up after ICU discharge. Given the major consequences on patient quality of life,... read more

Effect of P2Y12 Inhibitors on Organ Support-Free Survival in COVID-19 Patients

Effect of P2Y12 Inhibitors on Organ Support-Free Survival in COVID-19 Patients

n this randomized clinical trial of critically ill participants hospitalized for COVID-19, treatment with a P2Y12 inhibitor did not improve the number of days alive and free of cardiovascular or respiratory organ support.... read more

Acute Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome

This book covers all clinical aspects of acute respiratory distress syndrome (ARDS), from definition to treatment, focusing on the more recent recommendations and evidence-based medicine. The addressed topics are the... read more

Intubating the Critically Ill Patient: A Step-by-Step Guide for Success in the ED and ICU

Intubating the Critically Ill Patient: A Step-by-Step Guide for Success in the ED and ICU

Intubating critically ill patients is a process that requires a well-thought-out, step-by-step plan, specific to each patient. This book teaches the steps necessary to predict, prepare, perform, and provide pre and post-intubation... read more

Acute Respiratory Distress Syndrome: Advances in Diagnostic Tools and Disease Management

Acute Respiratory Distress Syndrome: Advances in Diagnostic Tools and Disease Management

Divided into thirteen chapters, this book provides a wealth of research-oriented findings and practical guidance, ranging from the definition, epidemiology and pathophysiology, to the diagnosis and management of the disease.... read more

Mechanical Ventilation from Pathophysiology to Clinical Evidence

Mechanical Ventilation from Pathophysiology to Clinical Evidence

This new book aims to give a comprehensive overview of the current challenges and solution posed to the health care professionals who need to use mechanical ventilation to treat their patients. Mechanical ventilation is... read more

Early Calorie and Protein Restriction Associated with Faster Recovery in Ventilated Patients

Early Calorie and Protein Restriction Associated with Faster Recovery in Ventilated Patients

Compared with standard calorie and protein targets, early calorie and protein restriction did not decrease mortality but was associated with faster recovery and fewer complications. Of 3,044 patients randomly assigned... read more

Strategies for Mechanical Ventilation in Patients with Brain Injury

Strategies for Mechanical Ventilation in Patients with Brain Injury

Although direct data to guide mechanical ventilation in brain-injured patients is accumulating, the current evidence base remains limited. Ventilatory considerations in this population should be extrapolated from high-quality... read more

Multifaceted Early Mobility Intervention Impact for Critically Ill Children

Multifaceted Early Mobility Intervention Impact for Critically Ill Children

This study will examine whether a multifaceted strategy to optimize early mobility affects the duration of mechanical ventilation, delirium incidence, and functional outcomes in critically ill children. This study will... read more

The Advanced Ventilator Book

The Advanced Ventilator Book

The Advanced Ventilator Book is a companion to the best-selling The Ventilator Book and is written for clinicians who already have a solid foundation in the basics of mechanical ventilation. It goes beyond the ventilator... read more

Methylene Blue Reduced Length of Stay in ICU

Methylene Blue Reduced Length of Stay in ICU

In patients with septic shock, methylene blue (MB) initiated within 24 h reduced time to vasopressor discontinuation and increased vasopressor-free days at 28 days. It also reduced length of stay in ICU and hospital without... read more

Is It Time to Abandon Routine Mask Ventilation Before Intubation?

Is It Time to Abandon Routine Mask Ventilation Before Intubation?

Mask ventilation in the period between induction and intubation has traditionally been used to confirm the ability to ventilate the patient while awaiting the onset of adequate neuromuscular blockade. However, recent studies... read more