Tag: mechanical ventilation
The MAP-SEPS Protocol: A New Frontier in Detecting Early Sepsis by Targeting Microcirculation
The MAP-SEPS trial is a prospective observational study designed to determine if a comprehensive, multimodal approach to peripheral perfusion monitoring can improve the early detection of sepsis and organ failure in critically... read more
Unmasking the Burden: High IAH Prevalence, Associated Morbidity, and Novel Mortality Predictors in Critical Care
This study on 85 critically ill patients revealed a high prevalence of Intra-Abdominal Hypertension (IAH) (54.1%). Key Findings: Primary Contributors: The main factors driving IAH were intravenous (IV) fluid administration... read more
Calming the Storm: Probiotics Significantly Modulate Inflammatory Cytokines in Pediatric Sepsis
This randomized double-blind study investigated the effect of probiotic treatment in children admitted to the pediatric intensive care unit (PICU) with sepsis. Inflammatory Improvement: Probiotic therapy led to a significant... read more
Managing Opioid Requirements for Buprenorphine/Naloxone Patients on Ventilators
In a study of 176 mechanically ventilated patients, researchers found that patients who were taking buprenorphine/naloxone before they were admitted to the hospital had similar opioid requirements during ventilation as those... read more
Postoperative Steroids Linked to Longer Time on Ventilator
Postoperative use of systemic corticosteroids was linked to a longer duration of mechanical ventilation (MV), but it did not increase mortality or overall complications. While the study's initial analysis did not show... read more
Hemodynamic and Neurological Presentations of Invasive Meningococcal Disease in Adults
Neurological and hemodynamic presentation of invasive meningococcal disease (IMD) are clinically and prognostically distinct. Recognition of these phenotypes is critical for appropriate management and prediction of outcome. Of... read more
Heterogenous Treatment Effect of Neuromuscular Blocking Agents for Moderate-to-severe ARDS
The systematic and short-term administration of cisatracurium in patients with moderate-to-severe ARDS appears to confer greater survival benefit in those with a higher baseline life expectancy. Further validation through... read more
Neurally Adjusted Ventilatory Assist Decreases the Requirement of Corticosteroids
This study aimed to evaluate the incidence of bronchopulmonary dysplasia (BPD) and the dosage of corticosteroids in extremely preterm infants with the implementation of neurally adjusted ventilatory assist (NAVA). This... read more
The Influencing Factors of Neonatal Extubation Failure
This study conducted a systematic review and meta-analysis of 22 studies, revealing significant differences in risk factors between the extubation success and failure groups. Subgroup analysis further showed variations in... read more
Increased Driving Pressure During Assisted Ventilation for Hypoxemic Respiratory Failure Is Associated with Lower ICU Survival
Driving pressure is marker of severity and a possible target for lung protection during controlled ventilation, but its value during assisted ventilation is unknown. Inspiratory holds provide an estimate of driving pressure... read more
Impact of Low-Dose Ketamine Infusion on Intracranial Pressure and Hemodynamics in Septic Shock Patients
Adult patients with septic shock, on hemodynamic support, had high-to-normal intracranial pressure (ICP). Low-dose continuous ketamine infusion as an adjunct sedative appeared to have favorable outcomes concerning ICP and... read more
Anticoagulation Management and Outcomes in Critically Ill Patients with Acute Mesenteric Ischemia
This study suggests a significant survival benefit of early full-dose anticoagulation in ICU patients with acute mesenteric ischemia and no difference in hemorrhagic complications. Early full-dose anticoagulation and revascularization... read more
Impact of Esketamine vs. Remifentanil on Hemodynamics and Outcomes in Mechanically Ventilated Septic Shock
This single-center, prospective, randomized, controlled pilot study compared the hemodynamic effects and prognosis of esketamine versus remifentanil, both used in combination with propofol, for sedation and analgesia in patients... read more
Teaching Pearls in Noninvasive Mechanical Ventilation
This book uses real-world clinical case analyses of hot topics to provide insights into noninvasive mechanical ventilation (NIV). Written by leading international teachers and experts, it features a selection of "major... read more
Finding the Ultimate Sedative
Critically ill patients requiring invasive mechanical ventilation often need continuous sedation for pain and anxiety. Propofol, a GABA potentiator, and Dexmedetomidine, an α2-adrenergic receptor agonist, are commonly used... read more
Early Multimodal Rehabilitation Safely Accelerates Recovery for Ventilated Patients
This single-center, controlled clinical trial investigates the efficacy and safety of an early multimodal rehabilitation program (MRP) versus a late MRP in mechanically ventilated adult patients in the intensive care unit... read more
Propofol vs. Midazolam Infusion: Effects on Cardiovascular Stability in Critically Ill Patients
A study compared the effects of propofol and midazolam infusions on cardiovascular stability in 75 critically ill patients requiring sedation in the intensive care unit at Azadi and Tikrit Teaching Hospitals from December... read more
Rib-Indexed POCUS vs. Chest X-Ray for Lung Recruitment Assessment in Ventilated Neonates with Moderate-Severe ARDS on Pulmonary Surfactant Therapy
Rib-indexed posterior approach POCUS is a reliable, radiation-free modality for real-time lung recruitment assessment in neonates with NARDS, demonstrating noninferiority to CXR. Notably, our study is the first to propose... read more
Mechanical Power Impact Normalized to Predicted Body Weight on Outcomes in Pediatric ARDS
Higher mechanical power (MP) was associated with fewer ventilator (VFD) and ICU free days (IFD). The causal effect of MP on VFD and IFD was fully mediated by the impairment in oxygenation. This is a post-hoc analysis of... read more
Endotracheal Tube Cuff Pressure Monitoring and VAP Occurrence
This study demonstrated that maintaining endotracheal tube cuff pressure at 30 cm H2O through monitoring every 8 h did not result in a greater incidence of under-inflation (pressures ... read more
Intubating the Critically Ill Patient: A Step-by-Step Guide for Success in the ED and ICU
Intubating critically ill patients is a process that requires a well-thought-out, step-by-step plan, specific to each patient. This book teaches the steps necessary to predict, prepare, perform, and provide pre and post-intubation... read more
Inadequate Empirical Antibiotic Therapy in VAP: Risk Factors and Outcomes
Ventilator-associated pneumonia (VAP) caused by MDR pathogens were highly likely to receive inadequate empirical antibiotic therapy. The mortality rate and intubation duration were significantly longer in inadequately treated... read more
