Immunosuppression Not Associated with a Higher Incidence of ICU-acquired Bacterial Bloodstream Infections

In this monocentric, retrospective observational cohort study, the incidence of ICU-acquired bacterial BSI was not different between immunocompromised and non-immunocompromised patients. This suggests that the clinical... read more

Two weaning strategies for NIV in COPD patients with ARF

Non-Invasive Ventilation (NIV) is a crucial therapy for managing acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD) with hypercapnic respiratory failure. Research has shown that NIV can decrease the rate... read more

Tezepelumab in a case of severe asthma exacerbation and influenza-pneumonia on VV-ECMO

We present a case of 43-year-old male patient with broadly by Omalizumab, Mepolizumab and Benralizumab pretreated allergic asthma, who suffered a near fatal exacerbation, triggered by an influenza A infection. Due to... read more

Prone Positioning During ECMO for Severe ARDS

The ongoing debate on optimal extracorporeal membrane oxygenation (ECMO) care emphasizes the need for rigorous investigation, acknowledging the value of observational data in routine The PRONECMO study, with its pragmatic... read more

Chest Computed Tomography Severity Score at ICU Admission and Respiratory Outcomes

COVID-19 patients with >50% lung involvement on Chest-CT admission presented higher chances to stay longer on invasive mechanical ventilation and more chances to developed ventilator-associated pneumonia. 121 patients... read more

Sepsis Mortality Among ICU Patients with Hematological Malignancy

Over the past two decades, there have been substantial improvements in mortality in hematological malignancy patients with sepsis, including across all levels of illness severity and in patients requiring mechanical ventilation.... read more

Clinical Outcomes in Critically Ill COVID-19 Unvaccinated Patients Admitted to the ICU

We analyzed unvaccinated critically ill ICU patients with COVID-19 and interpreted their demographics, clinical characteristics, comorbidities, and laboratory data upon ICU admission for a better understanding of their impact... read more

Dyspnea and Dyspnea-Associated Anxiety in ICU Patients

Dyspnea is frequently associated with anxiety, prolonged days on mechanical ventilation, and worse quality of life after discharge. It can also increase the risk of posttraumatic stress disorder post ICU discharge. However,... read more

Heat Shock Protein 27 in COVID-19 and non-COVID ARDS Pathogenesis

Acute respiratory distress syndrome (ARDS) is a common cause of hypoxemic respiratory failure in intensive care units that has increased dramatically as a result of the COVID-19 pandemic. In both COVID-19 and non-COVID... read more

Efficacy of High-Flow Nasal Cannula Oxygen Therapy in Patients with AHRF

This study suggests that high-flow nasal cannula (HFNC) therapy in general respiratory wards may be a potential rescue therapy for patients with respiratory failure. Electrical impedance tomography (EIT) potentially monitors... read more

Scheduled Intravenous Opioids

Maintaining comfort and analgesia is fundamental to providing adequate care in intensive care unit (ICU) patients. Pain assessment and its control remain the highest priorities and concerns among survivors of critical illness... read more

Effect of Mechanical Ventilation Under Intubation on Respiratory Tract Change of Bacterial Count

Mechanical ventilation under intubation may cause dysregulation of lower respiratory microbiota in rats. The most common 'second strike' in mechanically ventilated patients is a pulmonary infection caused by the ease with... read more

Convalescent Plasma Cuts Death by 10% in COVID Patients on Mechanical Ventilation

A randomized clinical trial in Belgium finds that convalescent plasma reduces death rates by about 10% in COVID-19 patients requiring invasive mechanical ventilation. University of Liege researchers led the open-label... read more

Haloperidol and Delirium: What is Next?

Haloperidol is, by far, the best-studied antipsychotic in ICU, appears to be safe in the dosing range used in these two trials and is easy to administer and titrate. For these reasons, if a clinician chooses to pharmacologically... read more

Enteral Citrulline Supplementation vs. Placebo in Mechanically Ventilated Patients

Among mechanically ventilated ICU patients without sepsis or septic shock, enteral L-citrulline administration did not result in a significant difference in SOFA score on day 7 compared to placebo. Of 120 randomized patients... read more

Delirium in Critically Ill Patients – Haloperidol Treatment

Haloperidol may reduce mortality and likely result in little to no change in the occurrence of SAEs/SARs compared with placebo in critically ill patients with delirium. However, the results were not statistically significant... read more

Ferroptosis and Pyroptosis Signatures in Critical COVID-19 Patients

Critical COVID-19 patients admitted to the intensive care unit (ICU) frequently suffer from severe multiple organ dysfunction with underlying widespread cell death. Ferroptosis and pyroptosis are two detrimental forms... read more

COVID-19 Critical and Intensive Care Medicine Essentials

This book provides healthcare professionals in Critical Care setting an easy consultation guide to fight against COVID-19. The book is divided into sections: Fundamentals of COVID-19, Pneumological critical care, Neurological... read more

COVID-19 Critical and Intensive Care Medicine Essentials

Cluster of Carbapenemase-Producing Carbapenem-Resistant Pseudomonas Aeruginosa Among ICU Patients

Treatment of carbapenemase-producing carbapenem-resistant Pseudomonas aeruginosa (CP-CRPA) infections is challenging because of antibiotic resistance. CP-CRPA infections are highly transmissible in health care settings because... read more

1-year Survival Rate of COVID-19 Infected Patients with ARDS Based on Ventilator Types

The study revealed that the utilization of non-ICU sophisticated ventilators was linked to a higher mortality rate when compared to standard ICU ventilators in COVID-19 patients with ARDS. However, given the shortage and... read more

Elevation of D-dimer Levels Associated with Early Need for Mechanical Ventilation Support in COVID-19 Patients

Hypoxia and thrombosis are hallmarks of severe COVID-19, and each of them can exaggerate the other, adding to the magnitude of the disease. Our study proposes that D-dimer, commonly used as a marker of thrombosis, can also... read more

Noninvasive Ventilation in Sleep Medicine and Pulmonary Critical Care

This book is an introduction to a comprehensive analysis of recent advances and clinical research in noninvasive mechanical ventilation (NIV) in Pulmonary, Critical Care, and Sleep Medicine. The objective of the book is to... read more

Noninvasive Ventilation in Sleep Medicine and Pulmonary Critical Care